A5006306835- Neural dynamics and brain function
- Functional Brain Connectivity Studies
- EEG and Brain-Computer Interfaces
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Psychedelics and Drug Studies
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuroscience and Neuropharmacology Research
- Stress Responses and Cortisol
- Advanced MRI Techniques and Applications
- Atomic and Subatomic Physics Research
- Neuroscience and Music Perception
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Multisensory perception and integration
- Hearing Loss and Rehabilitation
- Blind Source Separation Techniques
- Intraoperative Neuromonitoring and Anesthetic Effects
- Neural and Behavioral Psychology Studies
- Stroke Rehabilitation and Recovery
- Mindfulness and Compassion Interventions
- Psychosomatic Disorders and Their Treatments
- Transcranial Magnetic Stimulation Studies
Universidade Federal do Rio Grande do Norte
2013-2023
Hospital Universitário Onofre Lopes
2014-2020
Max Planck Society
2009-2012
Max Planck Institute of Psychiatry
2008-2012
Universidade de Ribeirão Preto
2006
Universidade de São Paulo
2006
Recent open-label trials show that psychedelics, such as ayahuasca, hold promise fast-onset antidepressants in treatment-resistant depression.To test the antidepressant effects of we conducted a parallel-arm, double-blind randomized placebo-controlled trial 29 patients with depression. Patients received single dose either ayahuasca or placebo. We assessed changes depression severity Montgomery-Åsberg Depression Rating Scale (MADRS) and Hamilton scale at baseline, 1 (D1), 2 (D2), 7 (D7) days...
The experiences induced by psychedelics share a wide variety of subjective features, related to the complex changes in perception and cognition this class drugs. A remarkable increase introspection is at core these altered states consciousness. Self-oriented mental activity has been consistently linked Default Mode Network (DMN), set brain regions more active during rest than execution goal-directed task. Here we used fMRI technique inspect DMN psychedelic state Ayahuasca ten experienced...
Graph theoretical analysis of functional magnetic resonance imaging (fMRI) time series has revealed a small-world organization slow-frequency blood oxygen level-dependent (BOLD) signal fluctuations during wakeful resting. In this study, we used graph measures to explore how physiological changes sleep are reflected in connectivity and network properties large-scale, low-frequency brain network. Twenty-five young healthy participants fell asleep 26.7 min fMRI scan with simultaneous...
We investigated human hippocampal functional connectivity in wakefulness and throughout non-rapid eye movement sleep. Young healthy subjects underwent simultaneous EEG magnetic resonance imaging (fMRI) measurements at 1.5 T under resting conditions the descent to deep Continuous 5 min epochs representing a unique sleep stage (i.e., wakefulness, stages 1 2, or slow-wave sleep) were extracted. fMRI time series of subregions formation (HF) (cornu ammonis, dentate gyrus, subiculum) extracted...
Abstract In a temporal difference learning approach of classical conditioning, theoretical error signal shifts from outcome deliverance to the onset conditioned stimulus. Omission an expected results in negative prediction signal, which is initial step towards successful extinction and may therefore be relevant for fear recall. As studies rodents have observed bidirectional relationship between rapid eye movement (REM) sleep, we aimed test hypothesis that REM sleep deprivation impairs recall...
Pranayama refers to a set of yoga breathing exercises. Recent evidence suggests that the practice pranayama has positive effects on measures clinical stress and anxiety. This study explored impact Bhastrika training program emotion processing, anxiety affect. We used randomized controlled trial design with thirty healthy young adults assessed at baseline after 4 weeks practices. Two functional MRI protocols were both post-intervention: an task as well resting-state acquisition. Our results...
A condition vital for the consolidation and maintenance of sleep is generally reduced responsiveness to external stimuli. Despite this, sleeper maintains a level stimulus processing that allows respond potentially dangerous environmental signals. The mechanisms subserve these contradictory functions are only incompletely understood.Using combined EEG/fMRI we investigated neural substrate protection by applying an acoustic oddball paradigm during light NREM sleep. Further, studied role evoked...
Hearing aids (HAs) are an effective strategy for auditory rehabilitation in patients with peripheral hearing deficits. Yet, the neurophysiological mechanisms behind HA use still unclear. Thus far, most studies have focused on changes system, although it is expected that deficits affect a number of cognitive systems, notably speech. In present study, we used audiometric evaluations 14 bilateral loss before and after one year continuous functional magnetic resonance imaging (fMRI) cortical...
Abstract Recent open label trials show that psychedelics, such as ayahuasca, hold promise fast-onset antidepressants in treatment-resistant depression. In order to further test the antidepressant effects of we conducted a parallel-arm, double-blind randomized placebo-controlled trial 29 patients with Patients received single dose either ayahuasca or placebo. Changes depression severity were assessed Montgomery–Åsberg Depression Rating Scale (MADRS) and Hamilton scale (HAM-D). Assessments...
The simultaneous acquisition of electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) data potentially allows measurement brain signals with both high spatial temporal resolution. Partial directed coherence (PDC) is a Granger causality measure in the frequency domain, which often used to infer intensity information flow over from EEG data. In current study, we propose new approach investigate connectivity resting-state (RS) EEG-fMRI by combining time-varying PDC...
Mirror therapy (MT) is becoming an alternative rehabilitation strategy for various conditions, including stroke. Although recent studies suggest the positive benefit of MT in chronic stroke motor recovery, little known about its neural mechanisms.To identify functional brain changes induced by a single intervention ischemic survivors, assessed both transcranial magnetic stimulation (TMS) and resonance imaging (fMRI).TMS fMRI were used to investigate 15 survivors immediately before after...
The increase of relative cerebral blood flow (rCBF) may contribute for a change in oxygenation level dependent signal (BOLD). main purpose this study is to investigate some aspects perfusional alterations the human brain response uniform stimulation: hypercapnia induced by breath holding. It was observed that BOLD increased globally during and it correlated with time This shows clear distinction between gray white matter, being greater grey matter.
Magneto/electroencephalography (M/EEG) studies of dreaming are an essential paradigm in the investigation neurocognitive processes human consciousness during sleep, but they limited by number observations that can be collected per study. Dream research also involves substantial methodological and conceptual variability, which poses problems for integration results. To address these issues, here we present DREAM database—an expanding collection standardized datasets on sleep M/EEG combined...