A5007139726- Neuroscience and Neuropharmacology Research
- Psychedelics and Drug Studies
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Tryptophan and brain disorders
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Biochemical Analysis and Sensing Techniques
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
- Prion Diseases and Protein Misfolding
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Circadian rhythm and melatonin
- Mental Health Research Topics
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Sleep and related disorders
- Pain Mechanisms and Treatments
- Trace Elements in Health
- Pharmacological Effects and Toxicity Studies
- Nonlinear Dynamics and Pattern Formation
- Primate Behavior and Ecology
- Epilepsy research and treatment
- Turtle Biology and Conservation
- Zebrafish Biomedical Research Applications
Universidade Federal do Rio Grande do Norte
2014-2024
Universidade de São Paulo
2004-2024
Instituto Nacional de Ciência e Tecnologia Translacional em Medicina
2018-2022
Instituto de Neurociências e Comportamento
2007-2021
Universidade Federal do Rio Grande
2021
Behavioral Pharma (United States)
2017
Centro Universitário do Rio Grande do Norte
2008
Universidade de Ribeirão Preto
2004-2007
Universidade Federal de Santa Catarina
2004-2006
Clinics Hospital of Ribeirão Preto
2005
Recent open-label trials show that psychedelics, such as ayahuasca, hold promise fast-onset antidepressants in treatment-resistant depression.To test the antidepressant effects of we conducted a parallel-arm, double-blind randomized placebo-controlled trial 29 patients with depression. Patients received single dose either ayahuasca or placebo. We assessed changes depression severity Montgomery-Åsberg Depression Rating Scale (MADRS) and Hamilton scale at baseline, 1 (D1), 2 (D2), 7 (D7) days...
Serotonergic psychedelics are emerging as potential antidepressant therapeutic tools, suggested in a recent randomized controlled trial with ayahuasca for treatment-resistant depression. Preclinical and clinical studies have that serum brain-derived neurotrophic factor (BDNF) levels increase after treatment serotoninergic antidepressants, but the exact role of BDNF biomarker diagnostic major depression is still poorly understood. Here we investigated healthy controls (
Ayahuasca is a traditional Amazon brew and its potential antidepressant properties have recently been explored in scientific settings. We conducted double-blind placebo-controlled trial of ayahuasca with treatment-resistant depression patients (n = 28) healthy controls 45).We are evaluating the blood inflammatory biomarkers: C-reactive protein interleukin 6, as consequence intake their correlation serum cortisol brain-derived neurotrophic factor levels. Blood samples were collected at...
Major depression is a highly prevalent mood disorder, affecting about 350 million people, and around 30% of the patients are resistant to currently available antidepressant medications. Recent evidence from randomized controlled trial supports rapid effects psychedelic ayahuasca in treatment-resistant depression. The aim this study was explore effect on plasma cortisol awakening salivary response, same group (MD) healthy volunteers (C). Subjects received single dose or placebo (dosing...
Pranayama refers to a set of yoga breathing exercises. Recent evidence suggests that the practice pranayama has positive effects on measures clinical stress and anxiety. This study explored impact Bhastrika training program emotion processing, anxiety affect. We used randomized controlled trial design with thirty healthy young adults assessed at baseline after 4 weeks practices. Two functional MRI protocols were both post-intervention: an task as well resting-state acquisition. Our results...
Abstract Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity mammals. Recently, specific component sleep structure has been proposed as part its homeostatic mechanism, named micro-arousal. Here, we studied unique progression dynamic behavior cortical hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) mice. Our main results comprised: (i) an abrupt drop LFP amplitude preceding micro-arousals which persisted...
Background and Purpose Transient receptor potential vanilloid 1 ( TRPV 1) TRP ankyrin TRPA are involved in many biological processes, including nociception hyperalgesia. Whereas the involvement of psychiatric disorders such as anxiety depression has been reported, little is known regarding role these conditions. Experimental Approach We investigated mice models [forced swimming test FST )] [elevated plus maze (EPM) ]. Key Results Administration antagonist HC 030031, 30 nmol 2 μL, i.c.v.)...
Dopamine and sleep have been independently linked with hippocampus-dependent learning. Since D2 dopaminergic transmission is required for the occurrence of rapid-eye-movement (REM) sleep, it possible that dopamine affects learning by way changes in post-acquisition REM sleep. To investigate this hypothesis, we first assessed whether modulation mice novel object preference, a task. Animals trained dark period, when reduced, did not improve significantly performance tested 24 h after training....
The incidence rate of major depression in adolescents reaches approximately 14%. This disorder is usually recurrent, without remission symptoms even after pharmacological treatment, and persists throughout adult life. Since the effects antidepressants take 2 weeks to begin, new therapies are under continuous exploration. Recent evidence suggests that psychedelics could produce rapid antidepressant effects. In this study, we evaluated potential ayahuasca a juvenile non-human primate model...
Abstract The oscillatory activity of hippocampal neuronal networks is believed to play a role in memory acquisition and consolidation. Particular focus has been given characterising theta (4–12 Hz), gamma (40–100 Hz) ripple (150–250 oscillations. Beyond these well‐described network states, few studies have investigated beta2 (23–30 vivo its link behaviour. A previous sudy showed that the exploration novel environments may lead appearance oscillations mouse hippocampus. In present study we...
The combined infusion of Banisteriopsis caapi stem and Psychotria viridis leaves, known as ayahuasca, has been used for centuries by indigenous tribes. is rich in N, N-dimethyltryptamine (DMT) monoamine oxidase inhibitors, with properties similar to those serotonin. Despite substantial progress the development new drugs treat anxiety depression, current treatments have several limitations. Alternative drugs, such may shed light on these disorders. Here, we present time-course behavioral...
The comprehension of the pathophysiology major depressive disorder (MDD) is essential to strengthening precision psychiatry. In order determine relationship between MDD and its clinical progression, analyzed by severity symptoms sleep quality, we conducted a study assessing different peripheral molecular biomarkers, including levels plasma C-reactive protein (CRP), serum mature brain-derived neurotrophic factor (mBDNF), cortisol (SC), salivary awakening response (CAR), patients with (
Episodic memory depends on the recollection of spatial and temporal aspects past experiences in which hippocampus plays a critical role. Studies hippocampal lesions rodents have shown that dentate gyrus (DG) CA3 are necessary to detect object displacement tasks. However, understanding real-time oscillatory activity underlying discrimination subtle pronounced displacements remains elusive. Here, we chronically implanted microelectrode arrays adult male Wistar rats record network oscillations...
The elevated T-maze (ETM) is an apparatus derived from the plus-maze test, which used to evaluate anxiety. Because anxiety a biasing factor in models of memory, this study proposed ETM as task for simultaneous assessment memory and mice. consists one enclosed two open arms. procedure based on avoidance spaces learned during training session, mice were exposed arm many times needed stay 300 s. In test assessed by re-exposing mouse latency enter was recorded. anxiolytic diazepam (DZP; 1 or 2...
Recurrence analysis and its quantifiers are strongly dependent on the evaluation of vicinity threshold parameter, i.e., to regard two points close enough in phase space be considered as just one. We develop a new way optimize order assure higher level sensitivity recurrence allow detection even small changes dynamics. It is used promote tool detect nonstationary behavior time signals or profiles. show that ability provides information about present status physical process responsible...
Sleep disturbance is a symptom consistently found in major depression, which associated with longer course of illness, reduced response to treatment and increased risk relapse recurrence. Chronic insomnia has been changes cortisol serum brain-derived neurotrophic factor (BDNF) levels, turn are also changed depression. Here we evaluated the relationship between sleep quality, salivary awakening (CAR) BDNF levels patients resistance depression (n = 18), compared control group healthy subjects...
Abstract Objective: Accumulating evidence from preclinical and clinical studies indicates that prenatal exposure to stress impairs the development of offspring brain facilitates emergence mental illness. This study aims describe impact restraint on cognition exploration an unfamiliar environment at adulthood in outbred strain mice. Methods: Late pregnant mice were exposed adult (60 days age) behaviours assessed object recognition task open field test. Findings: Prenatal (PNS) impaired new...