A5059287410- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Adipose Tissue and Metabolism
- Tryptophan and brain disorders
- Stress Responses and Cortisol
- Zebrafish Biomedical Research Applications
- Schizophrenia research and treatment
- Substance Abuse Treatment and Outcomes
- Pharmacological Receptor Mechanisms and Effects
- Circadian rhythm and melatonin
- Treatment of Major Depression
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- Impact of Light on Environment and Health
- Biotin and Related Studies
- Pain Mechanisms and Treatments
- Metabolomics and Mass Spectrometry Studies
- Regulation of Appetite and Obesity
- Genetic Mapping and Diversity in Plants and Animals
University of Colorado Denver
2008-2017
University of Colorado Anschutz Medical Campus
2013
University of Wisconsin–Madison
2004
Twice a year, normally diurnal songbirds engage in long-distance nocturnal migrations between their wintering and breeding grounds. If how sleep during these periods of increased activity has remained mystery. We used combination electrophysiological recording neurobehavioral testing to characterize seasonal changes cognition captive white-crowned sparrows (Zonotrichia leucophrys gambelii) across nonmigratory migratory seasons. Compared state, spent approximately two-thirds less time...
Cocaine addiction is a significant and complex disease. Part of this complexity caused by the variability drug experience early in use (initial responsiveness, amount use, etc.). In rats, individual differences initial cocaine responsiveness self-administration history both predict development sensitization, putative mechanism contributing to addiction. Here, we sought determine role these factors dose on sensitization cocaine9s motivational effects during earliest stages...
The role of sensitization in cocaine addiction remains debatable. In rats, non‐contingent cocaine‐induced locomotor is well documented. However, the relationship between this measure and measures self‐administration less clear. For example, repeated pre‐exposure enhances acquisition increases break points (BPs) for cocaine. Following escalation intake or BPs, however, some studies report tolerance to cocaine’s locomotor‐stimulating effects. Importantly, often assessed after long histories...
Cocaine addiction is a significant and complex disease. Part of this complexity due to variability the drug experience early in use (e.g., initial responsiveness, amount use, etc.). In rats, individual differences cocaine responsiveness self‐administration history both predict development sensitization, putative mechanism contributing addiction. Here we sought determine role these factors dose on sensitization cocaine's motivational effects during earliest stages self‐administration. Rats...
Individuals differ in their responsiveness to psychostimulants like cocaine, which produce activating effects largely by inhibiting the dopamine transporter (DAT). This differential may impact subsequent drug abuse and addiction. Adult outbred Sprague‐Dawley rats also cocaine can be classified as either low or high responders (LCRs HCRs), based on magnitude of each rat's locomotor activity resulting from its first exposure dose cocaine. Initially, inhibits striatal DAT only HCRs; LCR/HCR...