A5111502956- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Pain Mechanisms and Treatments
- Receptor Mechanisms and Signaling
- Pharmacological Receptor Mechanisms and Effects
- Neuropeptides and Animal Physiology
- Marine Biology and Ecology Research
- Marine and coastal plant biology
- Tryptophan and brain disorders
- Crustacean biology and ecology
- Schizophrenia research and treatment
- Adipose Tissue and Metabolism
- Marine Biology and Environmental Chemistry
- Marine and fisheries research
- Marine Bivalve and Aquaculture Studies
- Stress Responses and Cortisol
- Regulation of Appetite and Obesity
- Ion channel regulation and function
- Coral and Marine Ecosystems Studies
- Liver Disease and Transplantation
- Liver Disease Diagnosis and Treatment
- Marine Ecology and Invasive Species
- Patient Satisfaction in Healthcare
- Aerospace and Aviation Technology
- Cancer-related cognitive impairment studies
University of Colorado Denver
2005-2017
Dalhousie University
2013-2017
Memorial University of Newfoundland
2013-2017
Texas Research Institute
2015
Baylor College of Medicine
2015
Texas Medical Center
2015
The University of Queensland
2007-2014
Brigham Young University
2011
University of Denver
2008
University of Colorado Health
2006
When provisioning offspring, mothers balance the benefits of producing a few large, fitter offspring with costs decreased fecundity. The optimal between size and fecundity depends on environment. Theory predicts that larger have advantages in adverse conditions, but favorable conditions is less important. Thus, if environmental quality varies, selection should favor adaptively allocate resources response to local maximize maternal fitness. In bryozoan Bugula neritina, we show intensity...
Summary Transgenerational phenotypic plasticity is increasingly recognized as an important buffer of environmental change – many studies show that mothers alter the phenotype their offspring so to maximize performance in local environment. Fewer have examined capacity parents gametes cope with change. In organisms shed externally, are extremely vulnerable stresses and transgenerational phenotypes seems likely this group. a marine tubeworm, H ydroides diramphus, we manipulated salinity...
For organisms with complex life-cycles, the abundance of individuals in a given stage is driven by quantity previous stage. The successful recruitment juveniles to adult populations is, however, product both recruit and quality. Previous studies on quality have revealed that better higher growth survival, yet few considered how interact. In sessile marine invertebrate, we experimentally tested whether larval food environment causes variation affects post-metamorphic performance. We found...
The optimal balance of reproductive effort between offspring size and number depends on the fitness in a particular environment. variable environments experience, both among within life-history stages, are likely to alter size/fitness relationship favor different sizes. Hence, many experienced throughout complex life-histories present mothers with significant challenge optimally allocate their effort. In marine annelid, we tested egg performance across multiple including: fertilization,...
Summary Examples of simple phenotypic relationships, where variation in one stage directly affects a subsequent stage, are documented most taxa. However, environmental can mediate these and because organisms develop through multiple life‐history stages, each stage‐dependent environment has the potential to create new relationships interfere with existing relationships. Despite likelihood complex interactions among for resonate throughout life history, there few tests problem predictions how...
Developing new treatments that improve outcomes for patients with decompensated cirrhosis remains an unmet area of clinical need. The UK has a rich history being on the forefront trials this patient group. However, there have been challenges in achieving goal past decade, several negative studies as well struggling to achieve recruitment. This further exacerbated by changed landscape following COVID-19 pandemic. In response this, O’Shaughnessy report was commissioned identify potential...
Abstract. Settlement is an important process in the biphasic life histories of many marine invertebrates. Little known regarding fine‐scale behavioral mechanisms for finding and attaching to a suitable substratum, particularly under conditions that may impose potential challenge, such as flow. In this study, we examined settlement behavior cyphonautes larvae bryozoan, Membranipora membranacea , response two different algal substrata. Larvae showed strong preference settling on kelp...
Data from rodent antinociception models indicate that N-methyl-D-aspartate (NMDA) receptor antagonists do not produce alone or potentiate morphine antinociception, but attenuate the development of tolerance. This study examined antinociceptive effects noncompetitive NMDA antagonist dizocilpine, competitive (-)-6-phosphonomethyl-decahydroisoquinoline-3-carboxylic acid (LY235959), and glycine-site (+)-(1-hydroxy-3-aminopyrrolidine-2-one) [(+)-HA-966], in combination with a squirrel monkey...
It is difficult to determine the precise role of <i>N</i>-methyl-d-aspartate (NMDA) receptor system in reinforcing effects cocaine since uncompetitive NMDA antagonists alter self-administration different ways, depending on antagonist examined and behavior being measured. To increase understanding cocaine9s effects, this study measured competitive antagonist, LY235959 [(-)-6-phosphonomethyl-deca-hydroisoquinoline-3-carboxylic acid], rats that self-administered under both fixed ratio (FR) 1...
Cocaine addiction is a significant and complex disease. Part of this complexity caused by the variability drug experience early in use (initial responsiveness, amount use, etc.). In rats, individual differences initial cocaine responsiveness self-administration history both predict development sensitization, putative mechanism contributing to addiction. Here, we sought determine role these factors dose on sensitization cocaine9s motivational effects during earliest stages...