A5028112630- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Memory and Neural Mechanisms
- Cannabis and Cannabinoid Research
- Biochemical effects in animals
- Adipose Tissue and Metabolism
- Diet and metabolism studies
- Pharmacological Effects and Assays
- Regulation of Appetite and Obesity
- Neuroscience and Neural Engineering
- Prenatal Substance Exposure Effects
- Neural dynamics and brain function
- Birth, Development, and Health
- Tryptophan and brain disorders
- Behavioral Health and Interventions
- Neurological disorders and treatments
- Neuropeptides and Animal Physiology
- Substance Abuse Treatment and Outcomes
- Biochemical Analysis and Sensing Techniques
- Psychology of Development and Education
- HER2/EGFR in Cancer Research
- Biotin and Related Studies
University of Illinois Urbana-Champaign
2015-2025
Society for Neuroscience
2018
Center for Genomic Science
2006-2018
University of Colorado Denver
2007
University of Colorado Health
2002-2004
Indiana University Bloomington
1999-2004
University of Colorado Anschutz Medical Campus
2003-2004
University of New Mexico
1995
St. Francis Medical Center
1993
Saint Francis Medical Center
1993
Compared to adults, adolescents are at heightened risk for drug abuse and dependence. One of the factors contributing this vulnerability may be age-dependent differences in reward processing, with approaching through stimulus-directed, rather than goal-directed, processes. However, empirical evidence rodent models adolescence, particularly those that investigate both sexes, is limited. To address this, male female rats were (P30) or adults (P98) start experiment trained a Pavlovian approach...
Compared with adults, adolescent behavior is often characterized by reduced behavioral flexibility, increased sensitivity to reward, and likelihood take risks. These traits, which have been hypothesized confer heightened vulnerability psychopathologies such as substance use disorders (SUDs), the focus of studies in laboratory animal models that seek understand their neural underpinnings. However, rodent date typically used only males adopted standard methodological practices (e.g., weight...
Abstract In heterologous expression systems, dopamine transporter (DAT) cell‐surface localization is reduced after relatively prolonged exposure to d ‐amphetamine (AMPH) or (DA), suggesting a role for substrate‐mediated regulation of function. Here, we investigated whether brief, repeated periods substrate modulated function, first, in an vitro model system and, second, intact rat brain. human DAT‐expressing Xenopus laevis oocytes, low micromolar concentrations DA, AMPH tyramine markedly...
Abstract Repeated use of methamphetamine (METH) is known to dysregulate the dopaminergic system and induce long-lasting changes in behavior, which may be influenced by sex age exposure. Catechol-o-methyltransferase (COMT) an enzyme that involved breakdown catecholamines, its role dopamine clearance thought especially important prefrontal cortex (PFC) where transporter (DAT) expression relatively scarce. The first study this report utilized a rat model characterize ontogeny COMT protein PFC...
Repeated use of methamphetamine (METH) is known to dysregulate the dopaminergic system and induce long-lasting changes in behavior, which may be influenced by sex age exposure. Catechol-o-methyltransferase (COMT) an enzyme that involved breakdown catecholamines, its role dopamine clearance thought especially important prefrontal cortex (PFC) where transporter (DAT) expression relatively scarce. The first study this report utilized a rat model characterize ontogeny COMT protein PFC nucleus...
Repeated exposure to amphetamine (AMPH) induces long-lasting behavioral changes, referred as sensitization, that are accompanied by various neuroadaptations in the brain. To investigate chemical changes occur during we applied a comparative proteomics approach screen for neuropeptide rodent model of AMPH-induced sensitization. By measuring peptide profiles with matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and comparing signal intensities using principal...
Abstract Repeated exposure to psychostimulant drugs is associated with long‐lasting changes in cognition, particularly behavioral tasks that are sensitive prefrontal cortex function. Adolescents may be especially vulnerable these drug‐induced cognitive because of the widespread adaptations brain anatomy and function characteristic normal development during this period. Here, we used a differential reinforcement low rates responding task rats determine if amphetamine (AMPH) adolescence would...