A5070962598- Sleep and Wakefulness Research
- Neural dynamics and brain function
- EEG and Brain-Computer Interfaces
- Sleep and related disorders
- Functional Brain Connectivity Studies
- Neuroscience and Neuropharmacology Research
- Obstructive Sleep Apnea Research
- Photoreceptor and optogenetics research
- Neural and Behavioral Psychology Studies
- Neuroinflammation and Neurodegeneration Mechanisms
- Circadian rhythm and melatonin
- Advanced Neuroimaging Techniques and Applications
- Neuroscience of respiration and sleep
- Vestibular and auditory disorders
- Anesthesia and Sedative Agents
- Traumatic Brain Injury Research
- COVID-19 and healthcare impacts
- Motor Control and Adaptation
- Neuroscience and Music Perception
- Advanced MRI Techniques and Applications
- Neuroscience and Neural Engineering
- Migraine and Headache Studies
- Autoimmune Neurological Disorders and Treatments
- Respiratory Support and Mechanisms
- Tactile and Sensory Interactions
Washington University in St. Louis
2016-2025
Hope Center for Neurological Disorders
2023-2024
John Wiley & Sons (United States)
2020
Hudson Institute
2020
University of Wisconsin–Madison
2010-2013
Centre Hospitalier Universitaire de Liège
2011
University of Liège
2011
Legacy Emanuel Medical Center
2005
Legacy Health
2004
The electrophysiological correlates of anesthetic sedation remain poorly understood. We used high-density electroencephalography (hd-EEG) and source modeling to investigate the cortical processes underlying propofol anesthesia compare them sleep. 256-channel EEG recordings in humans during anesthesia. Hospital operating room. 8 healthy subjects (4 males) N/A Initially, induced increases power from 12–25 Hz. Loss consciousness (LOC) was accompanied by appearance slow waves that resembled NREM...
Slow wave activity during non–rapid eye movement sleep decreases with disease progression in patients Alzheimer’s disease.
Sleep loss is associated with cognitive decline in the aging population and a risk factor for Alzheimer’s disease (AD). Considering crucial role of immunomodulating genes such as that encoding triggering receptor expressed on myeloid cells type 2 (TREM2) removing pathogenic amyloid-β (Aβ) plaques regulating neurodegeneration brain, our aim was to investigate whether how sleep influences microglial function mice. We chronically sleep-deprived wild-type mice 5xFAD mouse model cerebral...
The existence of normal sleep in patients a vegetative state is still matter debate. Previous electrophysiological studies with disorders consciousness did not differentiate from minimally conscious state. Using high-density electroencephalographic recordings, 11 (six state, five state) were studied to correlate the changes associated behavioural vigilance (sustained eye closure and muscle inactivity). All showed clear decreases vigilance. In showing sustained periods, we identified several...
An accurate home sleep study to assess electroencephalography (EEG)-based stages and EEG power would be advantageous for both clinical research purposes, such as longitudinal studies measuring changes in over time. The purpose of this was compare scoring a single-channel recorded simultaneously on the forehead against attended polysomnography. Participants were recruited from centre investigating cognitively normal ageing Alzheimer's disease. Analysis overall epoch-by-epoch agreement found...
Sleep monitoring may provide markers for future Alzheimer's disease; however, the relationship between sleep and cognitive function in preclinical early symptomatic disease is not well understood. Multiple studies have associated short long times with impairment. Since risk of change age, a greater understanding how cognition changes over time needed. In this study, we hypothesized that longitudinal will non-linear total time, spent non-REM REM sleep, efficiency slow wave activity. To test...
The formation of new motor memories, which is fundamental for efficient performance during adaptation to a visuo-motor rotation, occurs when accurate planning achieved mostly with feedforward mechanisms. dynamics brain activity underlying the switch from feedback control still matter debate. Based on results studies in declarative learning, it likely that phase synchronization low and high frequencies as well their temporal modulation power amplitude underlie memories adaptation....
In this study, we characterized the patterns and timing of cortical activation visually guided movements in a task with critical temporal demands. particular, investigated neural correlates motor planning on-line adjustments reaching choice-reaction time task. High-density electroencephalography (EEG, 256 electrodes) was recorded 13 subjects performing movements. The topography movement-related spectral perturbation established across five 250-ms windows (from prestimulus to postmovement)...
Wide-field calcium imaging (WFCI) allows for monitoring of cortex-wide neural dynamics in mice. When applied to the study sleep, WFCI data are manually scored into sleep states wakefulness, non-REM (NREM) and REM by use adjunct EEG EMG recordings. However, this process is time-consuming often suffers from low inter- intra-rater reliability invasiveness. Therefore, an automated state classification method that operates on alone needed.A hybrid, two-step proposed. In first step,...
Sleep disturbance plays an important role in major depressive disorder (MDD). Prior investigations have demonstrated that slow wave activity (SWA) during sleep is altered MDD; however, results not been consistent across studies, which may be due part to sex-related differences SWA and/or limited spatial resolution of spectral analyses. This study sought characterize MDD utilizing high-density electroencephalography (hdEEG) examine the topography cortex MDD, as well variation disorder....
Modulation of brain state, e.g., by anesthesia, alters the correlation structure spontaneous activity, especially in delta band. This effect has largely been attributed to ∼1 Hz slow oscillation that is characteristic anesthesia and nonrapid eye movement (NREM) sleep. However, on structures spectral content activity across states (including NREM) not comprehensively examined. Further, discrepancies between dynamics observed with hemoglobin versus calcium (GCaMP6) imaging have reconciled....
Normal aging is associated with a variety of neurologic changes including declines in cognition, memory, and motor activity. These correlate neuronal synaptic structure function. Degradation brain network activity connectivity represents likely mediator age-related functional deterioration resulting from these changes. Human studies have demonstrated both general decreases spontaneous cortical disruption networks aging. Current techniques used to study cerebral are hampered either by limited...
Hypoglossal nerve stimulation (HGNS) is a potential alternative therapy for obstructive sleep apnea (OSA), but its efficacy in clinical setting and the impact of body mass index (BMI; calculated as weight kilograms divided by height meters squared) on treatment response remain unclear.
Neural activity in the delta range (1.0-4.5 Hz) during non-rapid eye movement (NREM) sleep is crucial for brain plasticity and overall health. Recent research has shown that changes NREM can occur locally, vary across different regions. Ischemic stroke results focal injury long-term disability. While disruption acute phase of known to hinder recovery, relationship between region-specific functional recovery remains poorly understood. To investigate these localized with high spatial...
BackgroundThe alpha-2 adrenergic agonist dexmedetomidine induces EEG patterns resembling those of non-rapid eye movement (NREM) sleep. Fulfilment slow wave sleep (SWS) homeostatic needs would address the assumption that functional biomimetic states.MethodsIn-home recordings were obtained from 13 healthy participants before and after sedation. Dexmedetomidine target-controlled infusions closed-loop acoustic stimulation implemented to induce enhance waves, respectively. during sedation staged...
Goldstein MR, Plante DT, Hulse BK, Sarasso S, Landsness EC, Tononi G, Benca RM. Overnight changes in waking auditory evoked potential amplitude reflect altered sleep homeostasis major depression. Objective: Sleep is depressive disorder (MDD). Pre‐ to postsleep decline (AEP) has been correlated with slow wave activity (SWA), suggesting that overnight AEP are homeostatically regulated healthy individuals. This study investigated whether the change and its relation SWA MDD. Method: Using...