A5070644910- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Cardiovascular Issues in Pregnancy
- Cardiovascular Health and Risk Factors
- Maternal and fetal healthcare
- Obesity, Physical Activity, Diet
- Maternal Mental Health During Pregnancy and Postpartum
- Physical Activity and Health
- Bariatric Surgery and Outcomes
- Blood Pressure and Hypertension Studies
- Pregnancy and Medication Impact
- Vitamin D Research Studies
- Neonatal Respiratory Health Research
- Cardiovascular Disease and Adiposity
- Maternal and Perinatal Health Interventions
- Assisted Reproductive Technology and Twin Pregnancy
- Preterm Birth and Chorioamnionitis
- Reproductive System and Pregnancy
- Pregnancy-related medical research
- Cardiovascular Health and Disease Prevention
- Fatty Acid Research and Health
- Breastfeeding Practices and Influences
- Prenatal Screening and Diagnostics
- Nutritional Studies and Diet
University of Pittsburgh
2016-2025
Magee-Womens Research Institute
2016-2025
Magee-Womens Hospital
2008-2024
University of Pittsburgh Medical Center
2007-2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2012-2024
National Heart Lung and Blood Institute
2016-2024
The University of Texas Medical Branch at Galveston
2022
Northwestern University
2020-2022
University of Toronto
2021
Pittsburg State University
2021
Vitamin D has direct influence on molecular pathways proposed to be important in the pathogenesis of preeclampsia, yet vitamin D-preeclampsia relation not been studied.We aimed assess effect maternal 25-hydroxyvitamin [25(OH)D] concentration risk preeclampsia and status newborns preeclamptic mothers.We conducted a nested case-control study pregnant women followed from less than 16 wk gestation delivery (1997-2001) at prenatal clinics private practices.Patients included nulliparous with...
Maternal vitamin D deficiency has been associated with numerous adverse health outcomes, but its association fetal growth restriction remains uncertain. We sought to elucidate the between maternal serum 25-hydroxyvitamin [25(OH)D] concentrations in early pregnancy and risk of small-for-gestational age birth (SGA) explore single nucleotide polymorphisms (SNP) receptor (VDR) gene SGA. conducted a nested case-control study nulliparous pregnant women singleton pregnancies who delivered SGA...
Prepregnancy overweight is a risk factor for mild preeclampsia and transient hypertension of pregnancy. Its association with severe subtypes these disorders has received less attention.To assess the prepregnancy body mass index (BMI) pregnancy, we used data from 1958-1964 prospective cohort study 38,188 pregnant women receiving care at 12 U.S. hospitals.There was monotonic, dose-response relation between BMI both preeclampsia, as well Compared white 20, odds ratios values 25 30 in were 1.7...
Background Preeclampsia (PE), especially severe or early PE, is a leading cause of morbidity and mortality among mothers infants. We estimated the population attributable fractions PE associated with pre-existing conditions nulliparous multiparous women.
Background: We sought to determine the association between maternal vitamin D status at ≤26 weeks’ gestation and risk of preeclampsia by clinical subtype. Methods: conducted a case–cohort study among women enrolled 12 US sites from 1959 1966 in Collaborative Perinatal Project. In serum collected (median 20.9 weeks) 717 who later developed (560 mild 157 severe cases) 2986 mothers without preeclampsia, we measured 25-hydroxyvitamin D, over 40 years later, using liquid chromatography–tandem...
To evaluate maternal and neonatal outcomes in healthy, nulliparous women classified with stage 1 hypertension under the revised American College of Cardiology Heart Association Guidelines to effects low-dose aspirin on this population.
Background Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective this study was to determine association between outcomes in first pregnancies and subsequent health. Methods Results Nulliparous Pregnancy Outcomes Study Monitoring Mothers‐to‐be Heart Health is a prospective observational cohort that followed 4484 women 2 7 years (mean 3.2 years) after their pregnancy. Adverse...
Gestational diabetes (GD) leads to earlier onset and heightened risk of type 2 diabetes, a strong factor for cardiovascular disease (CVD). However, it is unclear whether attaining normoglycemia can ameliorate the excess CVD associated with GD history. This study sought evaluate history glucose tolerance after pregnancy coronary artery calcification (CAC) in women, manifestation atherosclerotic predictor clinical events.
Women who deliver preterm are at increased risk for cardiovascular disease, but mechanisms not understood. The authors considered that inflammation in women with spontaneous birth (sPTB) might be related to their metabolic profile, such as lipids, and tested this a nested case-control study from the Pregnancy Exposures Preeclampsia Prevention Study (1997-2001). Cases were sPTB 34-<37 weeks (n = 76) or < 34 33). Controls randomly selected term births 228). Early pregnancy (C-reactive protein:...
Background: It is not well understood how air pollution leads to adverse pregnancy outcomes. One pathway may be through C-reactive protein, a biomarker of systemic inflammation that has been reported increase the risk preterm delivery. We examined whether influences serum concentrations protein in early pregnancy. Methods: studied 1696 pregnant women Allegheny County, PA, from 1997 2001. were assayed blood collected before 22nd week gestation. estimated levels particles less than 10 μm...
Evidence relating chronic hypertension to risk of small for gestational age (SGA) births is conflicting. To identify factors associated with SGA that may involve a placental pathogenesis, we related and other maternal be markers endothelial dysfunction preterm compared term births.Chronic hypertension, diabetes, body mass index, age, subfertility were in the Danish National Birth Cohort (N=81,008). Small those birth weight adjusted greater than two standard deviations below mean based on...
The objective of this study was to determine the association between maternal 25-hydroxyvitamin D (25(OH)D) and risk spontaneous preterm birth (sPTB) before 35 weeks' gestation. A random subcohort from US Collaborative Perinatal Project (1959-1965) sampled (n = 2,629) augmented with all remaining cases sPTB gestation for a total 767 cases. Banked serum samples collected at 26 or earlier were assayed 25(OH)D. Constructs vascular histology inflammatory developed placental pathology...
This study examined associations between maternal lipid levels at mid-pregnancy and preterm delivery, medically indicated or spontaneous.