A5014550072- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Fatty Acid Research and Health
- Nitric Oxide and Endothelin Effects
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Angiogenesis and VEGF in Cancer
- Antioxidant Activity and Oxidative Stress
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Neonatal Respiratory Health Research
- Epigenetics and DNA Methylation
- Eicosanoids and Hypertension Pharmacology
- Prenatal Screening and Diagnostics
- MicroRNA in disease regulation
- Cancer Risks and Factors
- Cardiovascular Health and Disease Prevention
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Cancer, Lipids, and Metabolism
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Lipid metabolism and disorders
- Iron Metabolism and Disorders
- Blood Pressure and Hypertension Studies
Magee-Womens Research Institute
2016-2025
University of Pittsburgh
2016-2025
Pittsburg State University
2020
Community Link
2019
University of California, San Diego
2017
NYU Langone Health
2017
Columbia University Irving Medical Center
2017
Johns Hopkins University
2017
Johns Hopkins Medicine
2017
Universitätsklinikum Aachen
2013
Abstract. The etiology and pathogenesis of the pregnancy syndrome preeclampsia remain poorly understood. There is substantial evidence to suggest that diverse manifestations preeclampsia, including altered vascular reactivity, vasospasm, discrete pathology in many organ systems, are derived from pathologic changes within maternal endothelium. With theme endothelial cell dysfunction emphasized, this review focuses on role oxidative stress (an imbalance favoring oxidant over antioxidant...
The largest gene cluster of human microRNAs (miRNAs), the chromosome 19 miRNA (C19MC), is exclusively expressed in placenta and undifferentiated cells. precise expression pattern function C19MC members are unknown. We sought to profile relative miRNAs primary trophoblast (PHT) cells exosomes. Using high-throughput profiling, confirmed by PCR, we found that among most abundant term trophoblasts. Hypoxic stress selectively reduced miR-520c-3p at certain time-points with no effect on other...
Gestational hypertension is differentiated into higher and lower risk by the presence or absence of proteinuria. We asked if hyperuricemia, a common finding in pregnancy hypertension, might also be an indicator increased risk. examined fetal outcome data from 972 pregnancies collected 1997 to 2002 nested case-control study. Participants were nulliparous with no known medical complications. The frequency preterm birth, duration pregnancy, small-for-gestational-age infants, birth weight...
Context: An excess of the soluble receptor, fms-like tyrosine kinase 1 (sFlt-1) may contribute to maternal vascular dysfunction in women with preeclampsia by binding and thereby reducing concentrations free endothelial growth factor placental (PlGF) circulation. The putative stimulus for increased sFlt-1 during preeclampsia, hypoxia due poor perfusion, is common both idiopathic intrauterine restriction. However, latter condition occurs without disease. Objective: We asked whether, as PlGF...
Altered angiogenesis and insulin resistance are associated with preeclampsia cardiovascular disease (CVD), women appear to be at increased risk of future CVD. We hypothesized that these factors detectable in asymptomatic postpartum a history may represent pathophysiological mechanisms bridging measured fasting insulin, glucose, vascular endothelial growth factor, its circulating inhibitor, soluble fms-like tyrosine kinase (sFlt-1) 29 normotensive 32 prior pregnancies 18.0 +/- 9.7 months...
The cardinal manifestations of the pregnancy-specific disorder preeclampsia, new-onset hypertension, and proteinuria that resolve with placental delivery have been linked to an extracellular protein made by placenta, soluble fms-like tyrosine kinase 1 (sFlt1), injures maternal vasculature. However, mechanisms which sFlt1, is heavily matrix bound, gain access systemic circulation remain unclear. Here we report preeclamptic placenta's outermost layer, syncytiotrophoblast, forms abundant...
The main pathogenic feature of preeclampsia is maternal endothelial dysfunction that results from impaired angiogenesis and reduced repair capacity. In addition, risk associated with vitamin D deficiency. We hypothesized D(3) stimulates proangiogenic properties colony-forming cells (ECFCs). ECFCs were obtained cultured cord blood characterized by immunocytochemistry flow cytometry. Proliferation, total length tubule formation on Matrigel, expression VEGF mRNA, pro-matrix metalloproteinases...
Pregnant women who subsequently develop preeclampsia are highly sensitive to infused angiotensin (Ang) II; the sensitivity persists postpartum. Activating autoantibodies against Ang II type 1 (AT ) receptor present in preeclampsia. In vitro and vivo data suggest that they could be involved disease process. We generated purified activating antibodies AT -AB) by immunizing rabbits AFHYESQ epitope of second extracellular loop, which is binding endogenous from patients with then -AB using...
Activating angiotensin II type 1 autoantibodies (AT1-AAs) develop in women with preeclampsia and may contribute to the disorder. Insulin resistance serum concentrations of antiangiogenic soluble fms-like tyrosine kinase (sFlt-1) are also increased compared normal pregnancy. sFlt-1 insulin decrease substantially after delivery; however, significant group differences persist postpartum. Women who have had at cardiovascular risk later life. We measured AT1-AAs groups previous (n=29) pregnancies...
Leptin, an adipocyte hormone involved in energy homeostasis, is important reproduction and pregnancy. Questions yet to be addressed include the source of higher leptin during pregnancy its relationship outcome fetal growth. The objective this study was investigate between placental gene expression, protein concentration maternal plasma among control pregnant women, women with pre-eclampsia growth-restricted infants. We also investigated expression enzymes cellular lipid balance: fatty acid...
Preeclampsia is a heterogeneous syndrome affecting 3% to 5% of all pregnancies. An imbalance the antiangiogenic and proangiogenic factors, soluble receptor fms-like tyrosine kinase 1 placental growth factor (PGF), thought contribute pathophysiology preeclampsia. Maternal plasma PGF were quantified by specific immunoassays in cross-sectional samples from 130 preeclamptic subjects 342 normotensive controls at delivery longitudinally 50 women who developed preeclampsia 250 controls. Among...