A5010066598- Maternal and Perinatal Health Interventions
- Pregnancy and preeclampsia studies
- Cardiovascular Issues in Pregnancy
- Maternal and fetal healthcare
- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Preterm Birth and Chorioamnionitis
- Pregnancy-related medical research
- Global Maternal and Child Health
- Maternal Mental Health During Pregnancy and Postpartum
- Assisted Reproductive Technology and Twin Pregnancy
- Cardiovascular Health and Risk Factors
- Cardiac Structural Anomalies and Repair
- Emergency and Acute Care Studies
- Neonatal and Maternal Infections
- Congenital Heart Disease Studies
- Cardiac, Anesthesia and Surgical Outcomes
- Reproductive Health and Contraception
- Cardiac Arrhythmias and Treatments
- Pregnancy and Medication Impact
- COVID-19 Impact on Reproduction
- Global Health Workforce Issues
- Trauma and Emergency Care Studies
- Healthcare Policy and Management
- Primary Care and Health Outcomes
University of Pennsylvania
2016-2025
National Heart Lung and Blood Institute
2024-2025
Hospital of the University of Pennsylvania
2013-2025
Shaare Zedek Medical Center
2024
Eunice Kennedy Shriver National Institute of Child Health and Human Development
2024
California University of Pennsylvania
2022-2024
Penn Center for AIDS Research
2024
University of Pennsylvania Health System
2024
Community Link
2020-2023
The Ohio State University
2022-2023
Background: Peripartum cardiomyopathy (PPCM) occurs in ≈1:2000 deliveries the United States and worldwide. The genetic underpinnings of PPCM remain poorly defined. Approximately 10% women with harbor truncating variants TTN (TTNtvs). Whether mutations other genes can predispose to is not known. It also known if presence TTNtvs predicts clinical presentation or outcomes. Nor it prevalence differs preeclampsia, strongest risk factor for PPCM. Methods: Women were retrospectively identified from...
Peripartum cardiomyopathy (PPCM) disproportionately affects women of African ancestry, but well-powered studies to explore differences in severity disease and clinical outcomes are lacking.To compare the characteristics, presentation, PPCM between American non-African women.This retrospective cohort study using data from January 1, 1986, through December 31, 2016, performed at University Pennsylvania Health System, a tertiary referral center serving population with high proportion...
To evaluate the effectiveness of four commonly used induction methods.
Background Identifying pregnancy‐associated risk factors before the development of major cardiovascular disease events could provide opportunities for prevention. The objective this study was to determine association between outcomes in first pregnancies and subsequent health. Methods Results Nulliparous Pregnancy Outcomes Study Monitoring Mothers‐to‐be Heart Health is a prospective observational cohort that followed 4484 women 2 7 years (mean 3.2 years) after their pregnancy. Adverse...
Background Preeclampsia and gestational hypertension are hypertensive disorders of pregnancy (HDP) that identify an increased risk developing chronic cardiovascular disease later in life. Postpartum follow-up may facilitate early screening treatment factors. Our objective is to describe patterns postpartum visits with primary care women's health providers (eg, family medicine obstetrics) among women without HDP a nationally representative sample commercially insured women. Methods Results We...
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<h3>Importance</h3> Hypertensive disorders of pregnancy are associated with increased risk cardiovascular disease, yet few interventions have targeted this population to decrease long-term risk. <h3>Objective</h3> To determine whether a digital health intervention improves physical activity in postpartum individuals hypertensive pregnancy. <h3>Design, Setting, and Participants</h3> This 12-week randomized clinical trial enrolled who delivered at the University Pennsylvania had disorder...
Importance The Mediterranean diet pattern is inversely associated with the leading causes of morbidity and mortality, including metabolic diseases cardiovascular disease, but there are limited data on its association adverse pregnancy outcomes (APOs) among US women. Objective To evaluate whether concordance to a around time conception lower risk developing any APO individual APOs. Design, Setting, Participants This prospective, multicenter, cohort study, Nulliparous Pregnancy Outcomes Study:...
<h3>Importance</h3> Hypertensive disorders of pregnancy are associated with future cardiovascular disease, perhaps because subclinical cardiac dysfunction before leading to impaired adaptation pregnancy. Natriuretic peptides promising biomarkers for detecting outside <h3>Objective</h3> To investigate whether higher concentrations N-terminal pro–brain natriuretic peptide (NT-proBNP) in early would be hypertensive and hypertension 2 7 years post partum. <h3>Design, Setting, Participants</h3>...
Abstract Preeclampsia is the most common placental pathology in pregnant females, with increased morbidity and mortality incurred on mother fetus. There a need for improved biomarkers diagnosis monitoring of this condition. Placental syncytiotrophoblasts at maternal-fetal interface release nanoparticles, including extracellular microvesicles, into maternal blood during pregnancy. Syncytiotrophoblast microvesicles (STEVs) are being studied their diagnostic potential physiologic role...
To determine whether adverse pregnancy outcomes are associated with a higher predicted 30-year risk of atherosclerotic cardiovascular disease (CVD; ie, coronary artery or stroke).
Abstract Background & Aims There is limited knowledge about hepatitis B virus ( HBV ) flare among pregnant women. We evaluated the incidence, determinants and outcomes of in a multicultural cohort ‐infected women United States. Methods performed retrospective study surface antigen‐positive cared for at hospital‐based clinics 4 medical centres Southeastern Pennsylvania from 2006 to 2015. The main outcome was incident (alanine aminotransferase [ ALT ] ≥2 times upper limit normal) during...