A5005413209- Liver Disease Diagnosis and Treatment
- Liver Disease and Transplantation
- Hepatitis C virus research
- Organ Transplantation Techniques and Outcomes
- Hepatitis B Virus Studies
- Renal Transplantation Outcomes and Treatments
- Gallbladder and Bile Duct Disorders
- Pancreatic and Hepatic Oncology Research
- Drug-Induced Hepatotoxicity and Protection
- Pancreatitis Pathology and Treatment
- Esophageal and GI Pathology
- HIV/AIDS drug development and treatment
- Liver Diseases and Immunity
- Hepatocellular Carcinoma Treatment and Prognosis
- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- HIV/AIDS Research and Interventions
- Pulmonary Hypertension Research and Treatments
- Inflammatory Bowel Disease
- Colorectal Cancer Screening and Detection
- Pediatric Hepatobiliary Diseases and Treatments
- Gastrointestinal disorders and treatments
- HIV-related health complications and treatments
- Mechanical Circulatory Support Devices
- Organ Donation and Transplantation
Temple University
2021-2024
Temple University Hospital
2023-2024
University of Pennsylvania
2014-2023
Adelphi Group (United Kingdom)
2023
Hospital of the University of Pennsylvania
2011-2020
University of Pennsylvania Health System
2011-2020
Center for Clinical Research (United States)
2014-2018
Penn Center for AIDS Research
2014-2017
University Gastroenterology
2014-2016
University of Alabama at Birmingham
2015
The direct-acting antivirals (DAAs) constitute an emerging group of small molecule inhibitors that effectively treat hepatitis C virus (HCV) infection, a common comorbidity in end-stage renal disease patients. To date, there are no data to guide use these agents kidney transplant authors collected from 20 consecutive recipients treated with interferon-free treatment regimens for HCV at their center: 88% were infected genotype 1; 50% had biopsy-proved advanced hepatic fibrosis on most recent...
Centralization of specialized health care services such as organ transplantation and bariatric surgery is advocated to improve quality, increase efficiency, reduce cost. The effect increased travel on access outcomes from these not fully understood.To evaluate the association between distance a Veterans Affairs (VA) transplant center (VATC) being waitlisted for liver transplantation, actually having transplant, mortality.Retrospective study veterans meeting eligibility criteria January 1,...
Differences in local organ supply and demand have introduced geographic inequities the Model for End-stage Liver Disease (MELD) score-based liver allocation system, prompting national debate patient-initiated lawsuits. No study to our knowledge has quantified sex disparities associated with clinical vs characteristics.To estimate proportion of disparity wait list mortality deceased donor transplant (DDLT) characteristics.This retrospective cohort used adult (age ≥18 years) liver-only...
There are limited data regarding intermediate-term outcomes in patients with persistent BK viremia. Other viral infections have been implicated the development of allosensitization through heterologous immunity, but relationship between viremia and donor-specific antibodies (DSAs) is unexplored. In 2008, we initiated routine post-transplant DSA screening at our center; 785 kidney or kidney–pancreas transplant recipients were included study. Of these recipients, 132 (17%) developed during...
This study examined whether treatment of Crohn's disease (CD) and ulcerative colitis (UC) with immunosuppressant medications was associated an increased risk death in the era prior to antitumor necrosis factor (TNF) therapies.This retrospective cohort used data from General Practice Research Database 1987 1997. CD UC patients were matched controls on age, sex, primary care practice. stratified according they during follow-up. Cox proportional hazards models adjusted for comorbidities define...
Acute decompensation in patients with chronic liver disease, resulting from acute kidney injury and infections, leads to significant morbidity mortality. It is unclear whether who develop acute-on-chronic failure (ACLF) have poor outcomes after transplantation.We performed a single-center retrospective cohort study of 332 evaluate the effect ACLF, defined as an rise Model for End-Stage Liver Disease score more than 5 within 4 weeks before transplantation, on posttransplant including stage...
Summary. Hepatitis C virus (HCV) infection is associated with systemic inflammation and metabolic complications that might predispose patients to atherosclerosis. However, it remains unclear if HCV increases the risk of acute myocardial infarction (MI). To determine whether an independent factor for MI among adults followed in general practices United Kingdom (UK), a retrospective cohort study was conducted The Health Improvement Network, from 1996 through 2008. Patients ≥18 years age at...
Background and aims Despite the use of administrative data to perform epidemiological cost-effectiveness research on patients with hepatitis B or C virus (HBV, HCV), there are no outside Veterans Health Administration validating whether International Classification Disease, Ninth Revision, Clinical Modification (ICD-9-CM) codes can accurately identify cirrhotic HBV HCV. The validation such algorithms is necessary for future studies. Methods We evaluated positive predictive value (PPV)...
Organ transplantation is an acceptable option for human immunodeficiency virus (HIV)-infected patients with end-stage kidney or liver disease. With worse outcomes on the waitlist, HIV-infected may actually be disproportionately affected by organ shortage in United States. One potential solution use of deceased donors (HIVDD), recently legalized HIV Policy Equity (HOPE) Act. This first analysis patient-specific data from HIVDD, retrospectively examining charts dying care at six clinics...
Cardiovascular disease is a leading cause of death among liver transplant (LT) recipients. With rising burden posttransplantation metabolic disease, increases in cardiovascular-related morbidity and mortality may reduce life expectancy after LT. It unknown if the risk long-term major cardiovascular events (MCEs) differs LT recipients with varying diabetic states. We performed retrospective cohort study from 2003 through 2013 to compare incidence MCEs patients (1) without diabetes, (2)...
Screening for hepatopulmonary syndrome (HPS) using pulse oximetry is recommended in liver transplant (LT) candidates because mortality increased, independently of the severity oxygenation defect. LT exception points may be afforded to those with HPS and severe hypoxemia. We assessed screening characteristics HPS. The Pulmonary Vascular Complications Liver Disease 2 study a multicenter, prospective cohort adults undergoing their first evaluation. Patients underwent protocolized assessment...
Abstract Purpose Before using computerized databases to study hepatitis C virus (HCV) epidemiology, the validity of diagnosis must be assessed. We determined accuracy HCV diagnostic codes within The Health Improvement Network (THIN), an electronic database containing medical record data from general practices in United Kingdom. Methods Patients with initial for infection and nonspecific viral between 2000 2007 THIN were identified. Questionnaires mailed practitioners caring a random sample...
Abstract Background The utility of electronic medical record databases for clinical research relies on the validity and completeness recorded diagnoses. This study assessed whether incidence cancer among patients in Health Improvement Network (THIN) database is comparable to that expected UK based national registry data. Methods We examined rates any other than non‐melanoma skin specific cancers colorectal, lung, pancreas, lymphoma from 1992 2007. Indirect standardization was used calculate...
ABSTRACT Purpose The validity of International Classification Diseases, Ninth Revision, Clinical Modification (ICD‐9‐CM) codes to identify diagnoses severe acute liver injury (SALI) is not well known. We examined the positive predictive values (PPVs) hospital ICD‐9‐CM in identifying SALI among health plan members Mini‐Sentinel Distributed Database (MSDD) for patients without liver/biliary disease and those with chronic (CLD). Methods selected random samples (149 disease; 75 CLD) a principal...
Living donor liver transplantation (LDLT) is a comparable alternative to deceased and can mitigate the risk of dying while waiting for transplant. Although evidence exists decreased utilization living kidney transplants among racial minorities, little known about access LDLT racial/ethnic minorities. We used Organ Procurement Transplantation Network/United Network Sharing data from February 27, 2002 June 4, 2014 all adult transplant recipients at LDLT-capable centers evaluate differential...