A5075646107- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Pesticide Exposure and Toxicity
- Drug-Induced Hepatotoxicity and Protection
- Effects and risks of endocrine disrupting chemicals
- Genetic factors in colorectal cancer
- Metabolism, Diabetes, and Cancer
- Maternal Mental Health During Pregnancy and Postpartum
- Liver Disease and Transplantation
- Global Maternal and Child Health
- Pregnancy and Medication Impact
- Colorectal Cancer Surgical Treatments
- Birth, Development, and Health
- Colorectal Cancer Treatments and Studies
- Heavy Metal Exposure and Toxicity
- Chemical Analysis and Environmental Impact
- Childhood Cancer Survivors' Quality of Life
- Economic and Financial Impacts of Cancer
- Neonatal Respiratory Health Research
- Acute Lymphoblastic Leukemia research
- Cancer Risks and Factors
- Demographic Trends and Gender Preferences
- COVID-19 and healthcare impacts
Kaiser Permanente
2011-2025
Suffolk University
2020
University of California, San Francisco
2014-2016
University of Pennsylvania
2016
National Institutes of Health
2016
Memorial Sloan Kettering Cancer Center
2016
Kaiser Permanente Oakland Medical Center
2014
Center for Environmental Health
2005-2011
University of California, Berkeley
2002-2010
Center for Children
2005-2010
The proportion of screening colonoscopic examinations performed by a physician that detect one or more adenomas (the adenoma detection rate) is recommended quality measure. However, little known about the association between this rate and patients' risks subsequent colorectal cancer (interval cancer) death.
Organophosphate (OP) pesticides are widely used in agriculture and homes. Animal studies suggest that even moderate doses neurodevelopmental toxicants, but there few humans.We investigated the relationship of prenatal child OP urinary metabolite levels with children's neurodevelopment.Participating children were from a longitudinal birth cohort primarily Latino farm-worker families California. We measured six nonspecific dialkylphosphate (DAP) metabolites maternal urine as well specific to...
BackgroundExposure to organophosphate (OP) pesticides, well-known neurotoxicants, has been associated with neurobehavioral deficits in children.ObjectivesWe investigated whether OP exposure, as measured by urinary dialkyl phosphate (DAP) metabolites pregnant women and their children, was attention-related outcomes among Mexican-American children living an agricultural region of California.MethodsChildren were assessed at ages 3.5 years (n = 331) 5 323). Mothers completed the Child Behavior...
Exposure to polybrominated diphenyl ether (PBDE) flame retardants is widespread, with 97% of Americans having detectable levels. Although PBDEs have been associated reproductive and hormonal effects in animals, no human studies examined their association fertility.This study was designed determine whether maternal concentrations serum collected during pregnancy are time menstrual cycle characteristics.Pregnant women (n = 223) living a low-income, predominantly Mexican-immigrant community...
The fecal immunochemical test (FIT) is commonly used for colorectal cancer screening and positive results require follow-up colonoscopy. However, intervals vary, which may result in neoplastic progression.To evaluate time to colonoscopy after a FIT its association with risk of advanced-stage disease at diagnosis.Retrospective cohort study (January 1, 2010-December 31, 2014) within Kaiser Permanente Northern Southern California. Participants were 70 124 patients aged 50 through years eligible...
Background: The fecal immunochemical test (FIT) is a common method for colorectal cancer (CRC) screening, yet its acceptability and performance over several rounds of annual testing are largely unknown. Objective: To assess FIT characteristics 4 screening. Design: Retrospective cohort study. Setting: Kaiser Permanente Northern Southern California. Patients: 323 349 health plan members aged 50 to 70 years on their mailing date in 2007 or 2008 who completed the first round were followed up...
We seek to determine whether dietary and supplement intake of specific micronutrients (zinc folate) antioxidants (vitamins C, E beta-carotene) is associated with semen quality.Ninety-seven healthy, non-smoking men provided were interviewed. Average daily nutrient from food supplements was derived a self-administered frequency questionnaire. Intake levels summarized as low, moderate high. Semen volume, sperm concentration, total count, motility, progressive motility progressively motile count...
OBJECTIVE. We investigated the relationship between prenatal exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) neurodevelopment of Mexican farm-workers' children in California. METHODS. Participants from Center for Health Assessment Mothers Children Salinas study, a birth cohort included 360 singletons with maternal serum measures p,p′-DDT, o,p′-DDT, p,p′-DDE. Psychomotor development mental were assessed Bayley Scales Infant Development at 6, 12, 24...
The human secondary sex ratio reportedly falls in populations subjected to exogenous stressors such as earthquakes or political and social upheavals. Explanations of the association include reduced conception males increased fetal deaths among males. latter explanation has been supported by research reporting that California fell 3 months, but not 8, 9 10 after terrorist attacks September 11, 2001. California's distance from raises questions whether results arose chance would be found...
BACKGROUNDWe examined pregnancy outcomes in New York City (NYC) and upstate after the September 11, 2001 World Trade Center disaster.
For mothers with chronic hepatitis B virus (HBV) infection, the Centers for Disease Control and Prevention recommends immunoprophylaxis to decrease perinatal transmission. However, its effectiveness risk factors failure have not been well-studied in community practice.To investigate of a contemporary protocol.Observational study.An HBV program within Kaiser Permanente Northern California.4446 infants born 3253 HBV-positive between 1997 2010.Adherence immunoprophylaxis, follow-up testing...
Paraoxonase 1 (PON1) detoxifies oxon derivatives of some organophosphate (OP) pesticides, and its genetic polymorphisms influence enzyme activity quantity. We previously reported that maternal urinary concentrations dialkyl phosphate (DAP) metabolites, a marker OP pesticide exposure, were related to poorer mental development maternally symptoms consistent with pervasive developmental disorder (PDD) in 2-year-olds participating the Center for Health Assessment Mothers Children Salinas...
Kawasaki disease (KD) may result in coronary aneurysm formation, but there is incomplete knowledge regarding its long-term effects. Our objective was to quantify the longer-term rates of adverse cardiac events a modern North American KD cohort.Using Kaiser Permanente Northern California population, we performed retrospective cohort study patients with history versus matched without KD. Chart review used confirm diagnosis and all outcomes interest, including acute syndrome, revascularization,...
Pollution may play a role in population trends of declining semen quality and regional differences time to pregnancy (TTP) industrialized societies. Dioxins including 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) have been suspected. In 1976, an explosion near Seveso, Italy resulted the highest TCDD exposure known residential populations. Twenty years later, we conducted retrospective cohort study, Seveso Women's Health Study.
Objectives: The COVID-19 pandemic reduced colorectal cancer (CRC) screening, but the rebound in testing and outcomes following has not been widely reported. We evaluated CRC test utilization neoplasia detection among screening eligible patients a large health system 2020 2021, compared to 2019 (pre-pandemic). Methods: Using retrospective cohort study design, fecal immunochemical (FIT) colonoscopy utilization, FIT positivity, were annually 2019-2021 Kaiser Permanente Northern California aged...
2,3,7,8-Tetrachlorobenzo-p-dioxin (TCDD), a halogenated compound that binds the aryl hydrocarbon receptor, is by-product of numerous industrial processes including waste incineration. Studies in rats and monkeys suggest TCDD may affect ovarian function. We examined relationship age at menopause population women residing near Seveso, Italy, 1976, time chemical plant explosion. included 616 who participated 20 years later Seveso Women's Health Study. All were premenopausal explosion, had...
Background: Polybrominated diphenyl ethers (PBDE), which are used as flame retardants, have been found to be higher in residents of California than other parts the United States.Objectives: We aimed investigate role immigration on PBDE levels Latino children.Methods: compared serum concentrations a population first-generation Mexican-American 7-year-old children (n = 264), who were born and raised [Center for Health Analysis Mothers Children Salinas (CHAMACOS) study], with 5-year-old Mexican...