A5032298497- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Childhood Cancer Survivors' Quality of Life
- Paraoxonase enzyme and polymorphisms
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Genetic Syndromes and Imprinting
- Pesticide Exposure and Toxicity
- Neonatal Respiratory Health Research
- Air Quality and Health Impacts
- Folate and B Vitamins Research
- Ethics and Legal Issues in Pediatric Healthcare
- Infection Control and Ventilation
- Digestive system and related health
- Child and Adolescent Health
- Gestational Diabetes Research and Management
- SARS-CoV-2 and COVID-19 Research
- Child Nutrition and Water Access
- Genetic Associations and Epidemiology
- Carcinogens and Genotoxicity Assessment
- Inflammatory Bowel Disease
- Acute Lymphoblastic Leukemia research
- Monoclonal and Polyclonal Antibodies Research
- Regulation of Appetite and Obesity
University of California, Berkeley
2016-2025
Center for Environmental Health
2011-2022
Universidad Nacional
2021
University of Arizona
2021
Clinica de Salud del Valle de Salinas
2021
London School of Hygiene & Tropical Medicine
2021
Innovative Genomics Institute
2021
Creative Commons
2018
Center for Children
2006-2016
Berkeley College
2013-2015
DNA methylation is an important epigenetic mark that can potentially link early life exposures to adverse health outcomes later in life. Host factors like sex and age strongly influence biological variation of methylation, but characterization these relationships still limited, particularly young children. In a sample 111 Mexican-American subjects (58 girls , 53 boys), we interrogated differences by at birth using the 450 K BeadChip umbilical cord blood specimens, adjusting for cell...
This study examined the association between genetic polymorphisms and enzyme activity for antioxidant enzymes that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) catalase.MnSOD, GPX1, catalase activities were measured in isolated erythrocytes of 231 healthy, non-smoking student volunteers (55% women, ages 17-21, majority Asian or Caucasian). DNA from blood clots was genotyped by Taqman PCR (C47T : MnSOD C593T GPX1) standard...
Author(s): Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A; Sharp, Gemma C; Almqvist, Catarina; Annesi-Maesano, Isabella; Arshad, Hasan; Baiz, Nour; Bakermans-Kranenburg, Marian J; Bakulski, Kelly M; Binder, Elisabeth B; Bouchard, Luigi; Breton, Carrie V; Brunekreef, Bert; Brunst, Burchard, Esteban G; Bustamante, Mariona; Chatzi, Leda; Cheng Munthe-Kaas, Monica; Corpeleijn, Eva; Czamara, Darina; Dabelea, Dana; Davey Smith, George; De Boever, Patrick; Duijts, Liesbeth; Dwyer,...
Genetic data are known to harbor information about human demographics, and genotyping commonly used for capturing ancestry by leveraging genome-wide differences between populations. In contrast, it is not clear what extent population structure captured whole-genome DNA methylation data. We demonstrate, using three large-cohort 450K array sets, that signal mirrored in can be further isolated more effectively the correlation of CpGs with cis-located SNPs. Based on these insights, we propose a...
Polybrominated diphenyl ethers (PBDEs) are lipophilic flame retardants that bioaccumulate in humans. Child serum PBDE concentrations California among the highest worldwide. PBDEs may be associated with obesity by disrupting endocrine systems.In this study, we examined whether pre- and postnatal exposure to components of pentaBDE mixture was childhood a population Latino children participating longitudinal birth cohort study Salinas Valley, California.We measured collected from 224 mothers...
Analysis of DNA methylation helps to understand the effects environmental exposures as well role epigenetics in human health. Illumina, Inc. recently replaced HumanMethylation450 BeadChip (450K) with EPIC BeadChip, which nearly doubles measured CpG sites >850,000. Although new chip uses same underlying technology, it is important establish if data between two platforms are comparable within cohorts and for meta-analyses. was assessed by 450K using whole blood from newborn (n = 109)...
Recent studies have demonstrated widespread pesticide exposures in pregnant women and children. Plasma paraoxonase 1 (PON1) plays an important role detoxification of various organophosphates. The goals this study were to examine the Center for Health Assessment Mothers Children Salinas (CHAMACOS) birth cohort Latina mothers their newborns living Valley, California, frequencies five PON1 polymorphisms coding region (192QR 55LM) promoter (−162AG, −909CG, −108CT) determine associations with...
Paraoxonase 1 (PON1) detoxifies oxon derivatives of some organophosphate (OP) pesticides, and its genetic polymorphisms influence enzyme activity quantity. We previously reported that maternal urinary concentrations dialkyl phosphate (DAP) metabolites, a marker OP pesticide exposure, were related to poorer mental development maternally symptoms consistent with pervasive developmental disorder (PDD) in 2-year-olds participating the Center for Health Assessment Mothers Children Salinas...
BackgroundLiving near traffic has been associated with asthma and other respiratory symptoms. Most studies, however, have conducted in areas high background levels of ambient air pollution, making it challenging to isolate an independent effect traffic. Additionally, most investigations used surrogates exposure, few measured pollutants directly as part the study.ObjectiveWe a cross-sectional study current symptoms children (n = 1,080) living at varying distances from high-traffic roads San...
Background Epidemiologic studies suggest that maternal organophosphorus (OP) pesticide exposure is associated with poorer fetal growth, but findings are inconsistent. We explored whether paraoxonase (PON1), a key enzyme involved in detoxification of OPs, could be an effect modifier this association. Methods The study population included 470 pregnant women enrolled the CHAMACOS Study, longitudinal cohort mothers and children living agricultural region California. analyzed urine samples...
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Methylation of Alu and long interspersed nucleotide elements (LINE‐1) is well‐established measure often used in epidemiologic studies. Yet, few studies have examined the effects host factors on LINE‐1 children. We characterized relationship age, sex, prenatal exposure to persistent organic pollutants (POPs), dichlorodiphenyl trichloroethane (DDT),...
Epigenetic changes such as DNA methylation may be a molecular mechanism through which environmental exposures affect health. Phthalates are known endocrine disruptors with ubiquitous in the general population including pregnant women, and they have been linked number of adverse health outcomes. We examined association between utero phthalate exposure altered patterns cord blood 336 Mexican‐American newborns. Concentrations 11 metabolites were analyzed maternal urine samples collected at 13...
People are exposed to phthalates through their wide use as plasticizers and in personal care products. Many endocrine disruptors have been associated with adverse health outcomes. However, knowledge gaps exist understanding the molecular mechanisms effects of exposure early late pregnancy. In this study, we examined relationship eleven urinary phthalate metabolites isoprostane, an established marker oxidative stress, among pregnant Mexican-American women from agricultural cohort. Isoprostane...
Exposures to phthalates, parabens, and other phenols are often correlated due their ubiquitous use in personal care products plastics. Examining these compounds as a complex mixture may clarify inconsistent relationships between individual chemicals childhood adiposity. Using data from the Center for Health Assessment of Mothers Children Salinas (CHAMACOS) study, longitudinal cohort children Valley, California (n = 309), we examined biomarkers 11 phthalate metabolites 9 phenols, including...
Abstract Smoking-associated DNA methylation (DNAm) signatures are reproducible among studies of mostly European descent, with mixed evidence if smoking accelerates epigenetic aging and its relationship to longevity. We evaluated smoking-associated DNAm in the Costa Rican Study on Longevity Healthy Aging (CRELES), including participants from high longevity region Nicoya. measured genome-wide leukocytes, tested Epigenetic Age Acceleration (EAA) five clocks estimates telomere length (DNAmTL),...