A5060065222- Effects and risks of endocrine disrupting chemicals
- Air Quality and Health Impacts
- Energy and Environment Impacts
- Health, Environment, Cognitive Aging
- COVID-19 Impact on Reproduction
- Diabetes Management and Education
- Per- and polyfluoroalkyl substances research
- Diet and metabolism studies
- Diabetes Treatment and Management
- Toxic Organic Pollutants Impact
- Climate Change and Health Impacts
- Hemodynamic Monitoring and Therapy
- Cardiac, Anesthesia and Surgical Outcomes
- Sepsis Diagnosis and Treatment
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Climate Change Communication and Perception
- Cardiovascular Issues in Pregnancy
- Law and Political Science
- Prenatal Substance Exposure Effects
- Healthcare Technology and Patient Monitoring
- Nutrition and Health in Aging
- Carcinogens and Genotoxicity Assessment
- Family and Disability Support Research
- Chronic Disease Management Strategies
- Cannabis and Cannabinoid Research
Sequoia Foundation
2020-2024
Sequoia (United States)
2022-2023
University of Cincinnati Medical Center
2022
Center for Environmental Health
2017-2020
University of California, Berkeley
2016-2020
The University of Texas Southwestern Medical Center
2017-2019
Southwestern Medical Center
2019
Oncology Hematology Care
2018-2019
California Environmental Protection Agency
2018
California Department of Public Health
2018
Are in-utero or peripubertal exposures to phthalates, parabens and other phenols found in personal care products associated with timing of pubertal onset boys girls? We some associations altered girls, but little evidence boys. Certain chemicals consumer products, including low molecular weight phenols, their precursors, are animal studies. Data were from the Center for Health Assessment Mothers Children Salinas (CHAMACOS) longitudinal cohort study which followed 338 children Valley,...
Background: Animal studies suggest that phthalates and bisphenol A (BPA), endocrine-disrupting chemicals found in many consumer products, may impact the timing of puberty. Objectives: We aimed to determine association prenatal exposure high-molecular-weight BPA with pubertal boys girls participating Center for Health Assessment Mothers Children Salinas (CHAMACOS) longitudinal cohort study. Methods: quantified urinary concentrations eight phthalate metabolites at two time points during...
The prevalence of asthma and allergy is increasing in US children. In utero exposure to chemicals used personal care products plastics may contribute increase these diseases.We quantified urinary concentrations eight phthalate metabolites bisphenol A mothers twice during pregnancy 1999-2000 Salinas, California. We assessed probable asthma, aeroallergies, eczema, spirometry their children at age 7, measured T helper 1 2 cells blood ages 2, 5, 7 (N = 392). employed Bayesian model averaging...
While many studies have investigated the health effects associated with acute exposure to fine particulate matter (particulate an aerodynamic diameter less than or equal 2.5 μm (PM2.5)), very few considered risks of specific sources PM2.5. We used city-specific source apportionment in 8 major metropolitan areas California from 2005–2009 examine associations source-specific PM2.5 exposures vehicular emissions, biomass burning, soil, and secondary nitrate sulfate emergency department visits...
Exposures to phthalates, parabens, and other phenols are often correlated due their ubiquitous use in personal care products plastics. Examining these compounds as a complex mixture may clarify inconsistent relationships between individual chemicals childhood adiposity. Using data from the Center for Health Assessment of Mothers Children Salinas (CHAMACOS) study, longitudinal cohort children Valley, California (n = 309), we examined biomarkers 11 phthalate metabolites 9 phenols, including...
Personal care product chemicals may be contributing to risk for asthma and other atopic illnesses. The existing literature is conflicting, many studies do not control multiple chemical exposures.We quantified concentrations of three phthalate metabolites, parabens, four phenols in urine collected twice during pregnancy from 392 women. We measured T helper 1 (Th1) 2 (Th2) cells their children's blood at ages two, five, seven, assessed probable asthma, aeroallergies, eczema, lung function age...
Increasing vitamin D deficiency and evidence for D's role in brain immune function have recently led to studies of neurodevelopment; however, few are specific autism spectrum disorder (ASD) pregnancy, a likely susceptibility period. We examined this case–control study 2000–2003 Southern Californian births; ASD intellectual disability (ID) were identified through the Department Developmental Services controls from birth certificates ( N = 534, 181, 421, respectively, analysis). Total...
Immune dysregulation, including aberrant peripheral cytokine/chemokine levels, is implicated in neurodevelopmental disorders (NDD) such as autism spectrum disorder (ASD). While the diagnosis of ASD more common males compared to females, sex effects immune dysregulation related neurodevelopment remain understudied. The aim this exploratory study was determine whether there are sex-specific neonatal with respect an or delayed development (DD) diagnosis. We utilized data from Early Markers for...
Abstract Associations between maternal immune dysregulation (including autoimmunity and skewed cytokine/chemokine profiles) offspring neurodevelopmental disorders such as autism have been reported. In autoantibody-related autism, specific maternally derived autoantibodies can access the fetal compartment to target eight proteins critical for neurodevelopment. We examined relationship profiles in second trimester of pregnancy mothers children later diagnosed with their neonates’ profiles....
Previous studies on in utero exposure to maternal environmental tobacco smoke (ETS) or active smoking and Autism Spectrum Disorder (ASD) have not been entirely consistent, no examined cotinine concentrations as an classification method. We measured stored second trimester serum for 498 ASD cases 499 controls born California 2011-2012. also obtained self-reported cigarette during immediately prior pregnancy, well covariate data, from birth records. Using unconditional logistic regression, we...
Abstract Data sharing requires cooperation from data generators (eg, epidemiologists, lab investigators) and users biostatisticians, computer scientists). generation use in human exposome studies require significant but different skill sets are separated temporally many cases. Sharing will maintaining a history of system to address the concerns around credit for conducting rigorous work authorship). also addressing needs facilitate harmonization, searchability QA/QC data. We present these...
Background and Aim: Prenatal exposure to endocrine-disrupting chemicals (EDCs) has been linked child neurodevelopmental disorders. Maternal immune activation during pregnancy is associated with adverse developmental outcomes. Whether EDCs influence maternal physiology unclear. Methods: We analyzed data from general population controls (n=439) of the Early Markers for Autism (EMA) Study, a case-control study children born 2000-2003 in Southern California. Eleven polychlorinated biphenyls...
There are known health concerns linked to prenatal tobacco and cannabis exposures. This study aims objectively determine the level of exposure in pregnant individuals from six race/ethnicity groups (Black, Hispanic, Asian Indian, Native American, Vietnamese, White) first three years following legalization recreational marijuana use 2018 California. We used a cross-sectional sample screening program participants (2018–2020) southern central California (N = 925). Exposures were estimated by...
Respiratory rate (RR) is a predictor of adverse outcomes. However, RRs are inaccurately measured in the hospital. We conducted quality improvement (QI) initiative using plan-do-study-act methodology on one inpatient unit safety-net hospital to improve RR accuracy. added time-keeping devices vital sign carts and retrained patient-care assistants newly modified workflow that included concomitant measurement during automated blood pressure measurement. The median was 18 (interquartile range...
Per American Diabetes Association guidelines, every hospital should adopt a hypoglycemia management protocol and all episodes of be documented in the medical record tracked. Chart audit findings at large urban acute care revealed that nurses were not always compliant with documentation and/or adherence to treatment protocol. Thus, quality improvement (QI) project was implemented improve compliance A clinical decision support system (CDSS) embedded into electronic health (EHR) enable visible...
Effective diabetes care after hospitalization is commonly limited by poor coordination. Key information from often not communicated to outpatient clinicians as rarely the reason for admission. Published interventions address this problem are or lack sustainable benefit. We studied effectiveness of Sweet Transitions (ST), a program providing and coordinating hospitalization. enrolled patients at 750-bed hospital with poorly controlled (A1C ≥ 9%) visits phone communication nurse practitioner...
Background/Aim: Phthalates, parabens, and phenols are chemicals used in plastics, cosmetics, other consumer products. These have demonstrated endocrine disrupting properties associated with altered pubertal timing animals, but few human studies exist. Methods: We measured biomarker concentrations of eight phthalates, three five urine collected during pregnancy from mothers participating the CHAMACOS cohort study. Children were followed through adolescence, clinical Tanner staging conducted...