A5064457476- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- COVID-19 and healthcare impacts
- Climate Change and Health Impacts
- Air Quality and Health Impacts
- Vitamin C and Antioxidants Research
- Cardiac, Anesthesia and Surgical Outcomes
- Trauma and Emergency Care Studies
- Pesticide Exposure and Toxicity
- Nutrition, Genetics, and Disease
- Delphi Technique in Research
- Pesticide and Herbicide Environmental Studies
- Minimally Invasive Surgical Techniques
- Consumer Attitudes and Food Labeling
- Thermoregulation and physiological responses
- Intraperitoneal and Appendiceal Malignancies
- Climate Change Communication and Perception
- Metabolomics and Mass Spectrometry Studies
- Appendicitis Diagnosis and Management
- Agriculture Sustainability and Environmental Impact
- Pregnancy and Medication Impact
- Child Nutrition and Water Access
- Advances in Oncology and Radiotherapy
- Exercise and Physiological Responses
- Indoor Air Quality and Microbial Exposure
Cyprus University of Technology
2016-2024
Institut de Virologie
2020-2022
University of Birmingham
2020
AstraZeneca (Brazil)
2020
Stryker (United Kingdom)
2020
Pfizer (United Kingdom)
2020
Merck (Germany)
2020
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...
Exposure to various pesticides, such as pyrethroids and chlorpyrifos, has been previously associated with adverse effects on children's health. Scientific evidence the human toxicity of glyphosate (GLY) its primary metabolite, aminomethylphosphonic acid (AMPA) is limited, particularly for children. This study aimed i) assess exposure determinants studied pesticides measured in children Cyprus, ii) determine association between urinary biomarkers DNA lipid oxidative damage.A health was set up...
Despite suggestive observational epidemiology and laboratory studies, there is limited experimental evidence regarding the effect of organic diet on human health. A cluster-randomized 40-day-organic (vs. 40-day-conventional) crossover trial was conducted among children (11–12 years old) from six schools in Cyprus. One restaurant provided all meals, adherence to intervention measured by parent-provided questionnaire/diary data. Biomarkers pyrethroid neonicotinoid pesticide exposures were...
Combined pollutant effects from indoor and outdoor sources on children's health, while being at school have not been holistically tackled. The aim of the School Temperature Environmental Pollutants Study (STEPS) was to perform a population representative assessment air quality (IAQ) in primary schools densely intermediate populated areas Cyprus (n = 42). study took place during May–July 2021 when school-specific COVID-19 protocol place. Questionnaire-based characteristics schools/classrooms...
Non-pharmacological interventions (NPI), including lockdowns, have been used to address the COVID-19 pandemic. We describe changes in environment and lifestyle of school children Cyprus before lockdown during re-opening, assess compliance NPI, using exposome concept.During June 2020, parents completed an online questionnaire about their children's lifestyle/behaviours for two periods; re-opening (May 21-June 26) following population-wide lockdown, period (before March).Responses were...
Abstract Data sharing requires cooperation from data generators (eg, epidemiologists, lab investigators) and users biostatisticians, computer scientists). generation use in human exposome studies require significant but different skill sets are separated temporally many cases. Sharing will maintaining a history of system to address the concerns around credit for conducting rigorous work authorship). also addressing needs facilitate harmonization, searchability QA/QC data. We present these...
Exposure to pesticides has been associated with oxidative stress in animals and humans. Previously, we showed that an organic food intervention reduced pesticide exposure damage (OD) biomarkers over time; however metabolic changes are not fully understood yet. We assessed perturbations of the urine metabolome response for children its association [3-phenoxybenzoic acid (3-PBA) 6-chloronicotinic (6-CN)]. also evaluated molecular signatures metabolites OD (8-iso-PGF2a 8-OHdG) related...
Abstract Non-pharmacological interventions (e.g., stay-at-home orders, school closures, physical distancing) implemented during the COVID-19 pandemic are expected to have modified routines and lifestyles, eventually impacting key exposome parameters, including, among others, activity, diet cleaning habits. The objectives were describe exposomic profile of general Cypriot population compliance population-wide measures March–May 2020 lower risk SARS-CoV-2 transmission, simulate measures’...
Understanding public perceptions on the health impacts of climate change will help to better address planetary challenges. This study aimed assess differences in Cypriot population regarding climate-related risks, information sources used, and self-assessed status over a three-year period, along with relationship between sociodemographics risks. Two cross-sectional surveys environmental risks change, sources, were conducted July–December 2018 (n = 185) August–September 2021 202) among adults...
Abstract The influence of elevated air temperatures recorded in various urban microenvironments adversely impacting biologically relevant disease end points has not yet been extensively tackled. This study is a post hoc analysis the TEMP pilot trial, randomized 2 × cross-over trial that examined changes metabolic and stress hormonal profiles healthy adults two settings (urban vs. rural) with distinctly different climatological characteristics during Mediterranean summer. aimed to association...
The Vasilikos Energy Center (VEC) is a large hydrocarbon industrial hub actively operating in Cyprus. There strong public interest by the communities surrounding VEC to engage with all stakeholders towards sustainable development of region. methodological framework exposome concept would allow for holistic identification relevant environmental exposures engaging most industrially contaminated sites. main objectives this study were to: (i) evaluate stakeholders' perceptions and health risks...
Organic food consumption in children and adults has been shown to reduce the body burden of chemical pesticides. However, there is little evidence potential health benefits associated with organic foods, especially children. The objectives this study were i) determine effectiveness an intervention reducing magnitude inflammation biomarker (CRP) aged 10-12 years, ii) assess association between biomarkers exposure pesticides CRP levels same population. This was part ORGANIKO cluster-randomized...
Summary Background School closures were part of a series non-pharmacological intervention (NPI) measures addressing the COVID-19 pandemic in Cyprus. We aimed to study changes environment, diet, behavior, personal hygiene, contacts, lifestyle choices and degree compliance NPI by primary school children Cyprus at home for two periods, i.e., before lockdown during re-opening using methodological context human exposome. Methods During June 2020, an online survey questionnaire was forwarded...
Introduction: Few studies have reported on the association between a systematic consumption of organic diet and human health effects. Pesticides, commonly used in conventional, but not agriculture, could lead to generation reactive oxygen species, indicative oxidative stress inflammatory responses. We aimed evaluate literature biomarkers inflammation, antioxidant capacity. Methods: Using PubMed, we searched for peer-reviewed articles that examined influence interventions altering key stress,...
Introduction: The effectiveness of a systematic organic diet in improving key parameters health human studies has not been well studied. objective this study was to determine the intervention an significantly reducing urinary pesticide metabolite concentrations and concomitantly affecting biomarkers inflammation oxidative stress young children. Methods: A pilot crossover designed for healthy children (n=10, 10-12 years old) from families historically consuming conventional (>80% weekly...
<h3>Introduction</h3> In the European Exposome Project for Health and Occupational Research (EPHOR), a working life exposome toolbox is developed to support evidence-based cost-effective prevention improve health at work. Our narrative synthesis showed potential of using non-invasive sampling occupational exposome. This pilot study aims develop, optimise validate methods, collection, storage, detection, quantification biomarkers in matrices, as alternatives e.g. whole blood collection via...
Introduction: The effectiveness of a systematic organic diet in improving key parameters health human studies has not been well studied. objective this study was to determine the intervention an significantly reducing urinary pesticide metabolite concentrations and concomitantly affecting biomarkers inflammation oxidative stress children.Methods: A 2 x cluster-randomised cross-over trial at subject level designed for healthy children (n=150, 11-12 years old) from families historically...
Introduction: To address the COVID-19 pandemic, non-pharmacological interventions (NPI) were implemented in Cyprus, including school closures, suspension of mass events, closures dining and recreation areas extensive physical distancing measures e.g. restrictions outdoor activities travel. Objectives: The objectives this study to: i) assess exposome changes general Cypriot population during implementation these afterwards, ii) to describe degree compliance NPI measures. Methods: A survey was...
Background: Exposure to pyrethroids and chlorpyrifos has been previously associated with adverse effects on children's health. Evidence the human toxicity of glyphosate (GLY) its primary metabolite, aminomethylphosphonic acid (AMPA) is limited, particularly for children. This study aimed i) assess exposure determinants pesticides measured in children Cyprus, ii) determine association between urinary biomarkers DNA lipid oxidative damage. Methods: A was set up Cyprus (ORGANIKO study) being...
Background and aim: Cities currently host the majority of global population generate more than 80% gross domestic product. Societal changes, e.g., urbanization migration shape health, quality life urban exposures. Extending human exposome framework, can be defined as totality environmental health indicators that populations' using city smaller, intra-city areas measurement units. The aim this study is to describe profile Limassol in summer 2017. Methods: A cross-sectional was conducted...