Ovnair Sepai
A5056488085- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Heavy Metal Exposure and Toxicity
- Occupational exposure and asthma
- Environmental Justice and Health Disparities
- Mercury impact and mitigation studies
- Indoor Air Quality and Microbial Exposure
- Potato Plant Research
- Chromium effects and bioremediation
- Chemical Safety and Risk Management
- Health Systems, Economic Evaluations, Quality of Life
- Animal testing and alternatives
- Glutathione Transferases and Polymorphisms
- Sulfur Compounds in Biology
- Ethics in Clinical Research
- Heavy metals in environment
- Arsenic contamination and mitigation
- Environmental and Social Impact Assessments
- Science, Research, and Medicine
- Risk Perception and Management
- Microplastics and Plastic Pollution
- Quality and Safety in Healthcare
National Health Service
2023-2025
UK Health Security Agency
2021-2024
Imperial College London
2024
Flemish Institute for Technological Research
2012-2023
Hrvatski zavod za javno zdravstvo
2023
Norwegian Institute of Public Health
2022
Public Health England
2013-2021
University of Würzburg
1995-2017
Newcastle University
1996-2016
Service Public Fédéral Technologie de l'Information et de la Communication
2012-2015
For Europe as a whole, data on internal exposure to environmental chemicals do not yet exist. Characterization of the individual chemical environment is expected enhance understanding threats health.We developed and applied harmonized protocol collect comparable human biomonitoring all over Europe.In 17 European countries, we measured mercury in hair cotinine, phthalate metabolites, cadmium urine 1,844 children (5-11 years age) their mothers. Specimens were collected 5-month period...
The toxicity of methylmercury (MeHg) in humans is well established and the main source exposure via consumption large marine fish mammals. Of particular concern are potential neurodevelopmental effects early life to low-levels MeHg. Therefore, it important that pregnant women, children women childbearing age are, as far possible, protected from MeHg exposure. Within European project DEMOCOPHES, we have analyzed mercury (Hg) hair 1799 mother-child pairs 17 countries using a strictly...
As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This builds on existing HBM capacity by aligning national or regional studies. The targets 3 age groups (i) children aged 6-11 years, (ii) teenagers 12-19 years and (iii) young adults 20-39 includes total 9493 participants (3151 children, 2953 3389 adults). Depending group, internal exposure to phthalates substitute Hexamoll® DINCH, brominated organophosphorus...
With modern populations in developed countries spending approximately 90% of their time indoors, and with carbon dioxide (CO2) concentrations inside being able to accumulate much greater than outdoors, it is important identify the health effects associated exposure low-level CO2 (<5000 ppm) typically seen indoor environments buildings (non-industrial environments). Although other reviews have summarised on health, none considered individual study designs investigations factored that into...
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...
The metal cadmium (Cd) is a widespread environmental pollutant with documented adverse effects on the kidneys and bones from long-term exposure, but insufficiently elucidated public health consequences such as risk of cardiovascular disease, hormone-related cancer in adults developmental children. This study first pan-European human biomonitoring project that succeeded performing harmonized measurements Cd urine comparable way mother-child couples 16 European countries. aim was to evaluate...
The EU human biomonitoring initiative, HBM4EU, aims to co-ordinate and advance (HBM) across Europe. Within its remit, the project is gathering new, policy relevant, EU-wide data on occupational exposure relevant priority chemicals developing new approaches for biomonitoring. In this manuscript, hexavalent chromium [Cr(VI)] study design presented as first example of HBM4EU approach. This involves eight European countries plans recruit 400 workers performing Cr(VI) surface treatment e.g....
Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was provide EU relevant data on exposure support the regulatory risk assessment decision-making. In addition, capability validity different biomarkers for were evaluated. involved nine European countries 399 workers industry sectors with exposures such as bath plating, applying or removing paint tasks. We also...
4,47′-Methylenediphenyl diisocyanate (MDI) is the most widely used isocyanate in manufacture of polyurethanes. MDI has been implicated as one major causes occupational asthma. Hydrolysis can yield 4,4′-methylenedianiline (MDA), which a suspected human carcinogen. Thus need to monitor exposure great significance. The use air monitors alone found be insufficient and there for sensitive markers recent long-term exposure. We obtained biological samples from group 20 workers exposed vapor during...
4,4'-Methylenedianiline (MDA) and 4,4'-methylenedi-phenyl diisocyanate (MDI) are important intermediates in the production of polyurethanes. In order to biomonitor people exposed low levels MDA or MDI we have developed sensitive methods measure hemoglobin (Hb) adducts urine metabolites. Adducts metabolites from 33 workers 27 were analyzed by gas chromatography—mass spectrometry after hydrolysis, extraction derivatization with heptafluorobutyric anhydride. Hb detected 31 out both N-acetyl-MDA...
Human biomonitoring (HBM) is an effective tool to assess human exposure environmental pollutants, but comparable HBM data in Europe are lacking. In order expedite harmonization of studies on a European scale, the twin projects COPHES (Consortium Perform Biomonitoring Scale) and DEMOCOPHES (Demonstration study Coordinate were formed, comprising 35 partners from 27 countries. research scheme guidelines developed exemplarily measure pilot mercury hair, cadmium, cotinine several phthalate...