A5060908063- Occupational and environmental lung diseases
- Heavy Metal Exposure and Toxicity
- Occupational exposure and asthma
- Air Quality and Health Impacts
- Advanced Glycation End Products research
- Chromium effects and bioremediation
- COVID-19 and Mental Health
- School Health and Nursing Education
- Workplace Health and Well-being
- Diabetes Management and Research
- Occupational Health and Safety Research
- Carcinogens and Genotoxicity Assessment
- Healthcare professionals’ stress and burnout
- Pancreatic function and diabetes
- Long-Term Effects of COVID-19
- Toxic Organic Pollutants Impact
- Trace Elements in Health
- Nanoparticles: synthesis and applications
- Neuroscience and Neuropharmacology Research
- Diabetes and associated disorders
- Electromagnetic Fields and Biological Effects
- Employment and Welfare Studies
- Pesticide and Herbicide Environmental Studies
- Sleep and Work-Related Fatigue
- Aluminum toxicity and tolerance in plants and animals
University of Perugia
2016-2025
State Key Laboratory of Respiratory Disease
2020
University of Gothenburg
2016
Azienda Ospedaliero-Universitaria Policlinico - Vittorio Emanuele
2002
Columbia University
2001
Environmental lead exposure is a possible causative factor for increased blood pressure and hypertension, but large studies at low-level are scarce, results inconsistent. We aimed to examine the effects of environmental in population-based sample. assessed associations between systolic/diastolic hypertension 4452 individuals (46–67 years) living Malmö, Sweden, 1991–1994. Blood was measured using mercury sphygmomanometer after 10 min supine rest. Hypertension defined as high systolic (≥140...
From 22 March until 18 May 2020, a complete lockdown in Italy was ordered as countermeasure against the COVID-19 pandemic. Social isolation measures affect some populations more than others, and people with drug and/or alcohol disorders (SUDs) are likely to be adversely affected. This study presents, for first time, laboratory data on use of drugs high-risk population during Italy's wave Thirty subjects SUDs were monitored illicit every 3 months before, after lockdown, by hair analysis. The...
Exposure to hexavalent chromium [Cr(VI)] may occur in several occupational activities, e.g., welding, Cr(VI) electroplating and other surface treatment processes. The aim of this study was provide EU relevant data on exposure support the regulatory risk assessment decision-making. In addition, capability validity different biomarkers for were evaluated. involved nine European countries 399 workers industry sectors with exposures such as bath plating, applying or removing paint tasks. We also...
Abstract Objectives The aim of this work is to investigate the biological effects IQOS smoking on human gingival fibroblasts and keratinocytes analysing cell viability, morphology, migration, apoptosis cycle. Background Electronic cigarettes tobacco heating systems have been marketed reduce damages caused by combustion. Methods Human viability was determined a colorimetric assay measuring mitochondrial dehydrogenase activity (MTT assay); after an in vitro exposure 24 h, morphology analysed...
The research aimed to investigate the incidence of SARS-CoV-2 breakthrough infections and their determinants in a large European cohort more than 60,000 health workers.A multicentric retrospective study, involving 12 centers, was carried out within ORCHESTRA project, collecting data up 18 November 2021 on fully vaccinated workers. cumulative investigated with its association occupational social-demographic characteristics (age, sex, job title, previous infection, antibody titer levels, time...
Background: The Work Ability Index (WAI) measures how well employees’ abilities match their job demands. This study assessed the WAI among health workers and explored age, gender, roles affected it. research was conducted in a central Italian hospital, with focus on undergoing surveillance between September 2020 April 2021. Methods: Data were collected using validated questionnaires that risk factors for metabolic syndrome participants. Demographic information, including occupation, also...
Oxidative stress is considered to be a key factor of the pathogenesis Parkinson’s disease, multifactorial neurodegenerative disorder characterized by reduced dopaminergic neurons in substantia nigra pars compacta and accumulated protein aggregates. Rotenone worldwide-used pesticide that induces most common features direct inhibition mitochondrial complex I. Rotenone-induced models, as well brain tissues from patients, are presence both lipid peroxidation oxidation markers resulting increased...
In recent years, there has been an increase in the non-medical use of psychoactive prescription drugs including pregabalin (PGB). Studies have shown that multiple drug users and patients methadone treatment programs administered PGB at high dosages order to achieve euphoria, reduce withdrawal symptoms, or potentiate effects methadone. For these reasons, accurate toxicological monitoring is required for high-risk individuals. The present study investigated whether could be detected hair...
The increasing use of nanomaterials in a variety industrial, commercial, medical products, and their environmental spreading has raised concerns regarding potential toxicity on human health. Titanium dioxide nanoparticles (TiO2 NPs) represent one the most commonly used nanoparticles. Emerging evidence suggested that exposure to TiO2 NPs induced reproductive male animals. In this vitro study, porcine prepubertal Sertoli cells (SCs) have undergone acute (24 h) chronic (from 1 up 3 weeks)...
Lately, nickel oxide nanoparticles (NiO NPs) have been employed in different industrial and biomedical fields. Several studies reported that NiO NPs may affect the development of reproductive organs inducing oxidative stress and, resulting male infertility. We investigated vitro effects on porcine pre-pubertal Sertoli cells (SCs) which undergone acute (24 h) chronic (from 1 up to 3 weeks) exposure at two subtoxic doses μg/ml 5 μg/ml. After we performed following analysis: (a) SCs...
To prove equivalence of individual, clinically titrated basal insulin doses glargine 300 units ⋅ mL-1 (Gla-300) and degludec 100 (Deg-100) under steady state conditions in a single-blind, randomized, crossover study, on the glucose pharmacodynamics (PD) people with type 1 diabetes (T1D).Subjects T1D (N = 22, 11 men, age 44.3 ± 12.4 years, disease duration 25.5 11.7 A1C 7.07 0.63% [53.7 6.9 mmol mL-1], BMI 22.5 2.7 kg · m-2), naïve to Gla-300 Deg-100, underwent 24-h euglycemic clamps...
Abstract Background The International Agency for Research on Cancer (IARC) recently classified glyphosate, the most used herbicide worldwide, as a probable human carcinogen. We inquired into association between occupational exposure to glyphosate and risk of lymphoma subtypes in multicenter case-control study conducted Italy. Methods Italian Gene-Environment Interactions Lymphoma Etiology (ItGxE) took place 2011–17 six centres. Overall, 867 incident cases 774 controls participated study....
As time passes, the long-term effects of COVID-19 pandemic are becoming increasingly apparent. The extreme restrictions imposed during have had detrimental impacts on most vulnerable groups, such as individuals suffering from substance and/or alcohol disorders (SUDs). This study reports quarterly laboratory data and drug use in 150 subjects with SUDs that were examined using hair analysis for 2 years before start until after end Italian health emergency. Overall, it was found number who used...