A5030496747- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Agricultural safety and regulations
- Effects and risks of endocrine disrupting chemicals
- Energy and Environment Impacts
- Health, Environment, Cognitive Aging
- Nutritional Studies and Diet
- Pesticide Exposure and Toxicity
- Occupational exposure and asthma
- Organoselenium and organotellurium chemistry
- Pesticide Residue Analysis and Safety
- Noise Effects and Management
- Electromagnetic Fields and Biological Effects
- Air Quality Monitoring and Forecasting
- Human Health and Disease
- Potato Plant Research
- Climate Change and Health Impacts
- Essential Oils and Antimicrobial Activity
- Obesity, Physical Activity, Diet
- Chemical Safety and Risk Management
- Aluminum toxicity and tolerance in plants and animals
- Magnetic and Electromagnetic Effects
- Safe Handling of Antineoplastic Drugs
- Synthesis and characterization of novel inorganic/organometallic compounds
- Animal testing and alternatives
European Food Safety Authority
2022-2024
University of Perugia
2014-2022
Unilever (United Kingdom)
2019-2020
Università di Camerino
2014-2017
University of Siena
2016-2017
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA) in food. Regarding PFOS PFOA occurrence, final data set available dietary exposure assessment contained total 20,019 analytical results (PFOS n = 10,191 9,828). There were large differences between upper lower bound due methods with insufficient sensitivity. CONTAM Panel considered estimates be closer true levels....
The CONTAM Panel updated the assessment of risks for human health related to presence 3-monochloropropane diol (3-MCPD) and its fatty acid esters in food published 2016 view scientific divergence identified establishment tolerable daily intake (TDI) Joint FAO/WHO Expert Committee on Food Additives Contaminants (FAO/WHO) report 2017.In this update, dose-response analysis was performed following recent EFSA Scientific guidance use benchmark dose (BMD) approach risk assessment, a review...
Poppy seeds are obtained from the opium poppy (Papaver somniferum L.). They used as food and to produce edible oil. The plant contains narcotic alkaloids such morphine codeine. do not contain alkaloids, but can become contaminated with a result of pest damage during harvesting. European Commission asked EFSA provide an update Scientific Opinion on in seeds. assessment is based data morphine, codeine, thebaine, oripavine, noscapine papaverine seed samples. CONTAM Panel confirms acute...
Abstract Aiming at accelerating the implementation of cumulative risk assessment to pesticide residues, this report describes a two-step prioritisation analysis, on individual pesticides and target organ systems, that allows identify (i) low-priority substances expected have marginal contribution risk, (ii) high priority systems be addressed in future assessments. The analysis encompassed 350 36 raw primary commodities plant origin surveyed monitoring cycle 2019–2021, carried out 30...
The present study was undertaken to evaluate, in the HepG2 human hepatoma cell line, vitro cytotoxic, genotoxic, and apoptotic activities of estragole (1), contained essential oil Foeniculum vulgare (fennel) suspected induce hepatic tumors susceptible strains mice. Toward this end, an MTT cytotoxicity assay, a trypan blue dye exclusion test, double-staining (acridine orange DAPI) fluorescence viability single-cell microgel-electrophoresis (comet) mitochondrial membrane potential (Δψm) DNA...
4,15-Diacetoxyscirpenol (DAS) is a mycotoxin primarily produced by
Homeless persons can be considered a vulnerable group and several studies showed in this an higher prevalence of chronic infectious diseases, lower mental health status, abuse alcohol. The aim our study was to investigate the status homeless Padua, Italy, administering questionnaire composed by SF-36 EQ-5D.We conducted cross-sectional from 15 December 2015 February 2016.We enrolled 73 welcomed municipal dorm Padua. 5 refused participate study; 9 had incompatible with participation study.We...
There is considerable interest in adverse outcome pathways (AOPs) as a means of organizing biological and toxicological information to assist data interpretation method development. While several chemical sectors have shown progress applying this approach, has not been the case food sector. In present study, safety evaluation reports additives listed Annex II Regulation (EC) No 1333/2008 European Union were screened qualitatively quantitatively characterize toxicity induced laboratory...
The prevalence of obesity among Italian children has reached such alarming levels as to require detailed studies the causes phenomenon. A cross-sectional study was carried out in order assess weight status 1164 aged 6-8 years (the Monitoring Air Pollution Effects on Children for Supporting Public Health Policy (MAPEC_LIFE) cohort) and identify any associations between selected socio-economic environmental factors overweight/obesity. data were obtained by means a questionnaire given parents,...
In the last decade, adverse outcome pathways have been introduced in fields of toxicology and risk assessment chemicals as pragmatic tools with broad application potential. While their use pharmaceutical cosmetics sectors has well documented, food area remains largely unexplored. this respect, an expert group International Life Sciences Institute Europe recently explored safety evaluation additives. A key activity was organization a workshop, gathering delegates from regulatory, industrial...
The European Commission requested EFSA to evaluate whether a series of dyes are covered by the 'Guidance on methodological principles and scientific methods be taken into account when establishing Reference Points for Action (RPAs) non-allowed pharmacologically active substances present in food animal origin' which group they should attributed according this guidance. Although these not registered use food-producing animals Union, may used illegally aquaculture their antimicrobial...
The Mediterranean diet (MD) is considered one of the healthiest dietary models, as it decreases risk chronic diseases and may modulate organism's early response to environmental pollution. In recent decades, countries have been replacing their traditional with other less healthy eating habits, especially among children teenagers.The aim this study was evaluate MD level adherence in 6-8 year old Italian children, relation residence, lifestyle, social family contexts.A questionnaire...
Phenylselenenylzinc chloride (PhSeZnCl) is an air-stable selenolate, easily synthesizable through oxidative insertion of elemental zinc into the Se-halogen bond commercially available phenylselenyl chloride. PhSeZnCl was shown to possess a marked GPx-like activity both in NMR and vitro tests, effectively react with cellular thiols, supposed for potential use chemotherapy drug-resistant cancers. However, hepatic cells has never been tested before now. In this approach, we evaluated cytotoxic,...
The MAPEC-Life project aims to study the biological effects of early exposure air pollutants on oral mucosa cells school-age children in five Italian cities. A questionnaire was created evaluate association between outdoor and indoor airborne pollutants, lifestyle, diet biomarker effects. feasibility reliability were evaluated.
The aim of the MAPEC_LIFE (Monitoring Air Pollution Effects on Children for Supporting Public Health Policy) study is to evaluate associations between concentrations air pollutants and early biological effects in children living five Italian towns (Brescia, Torino, Lecce, Perugia Pisa) characterised by varying levels pollution.This paper presents results micronucleus cytome assays performed oral mucosa cells subjects Lecce (Puglia, Italy) their relationship factors associated with...
Electric arc welding is known to involve considerable exposure extremely-low-frequency magnetic fields (ELF-MF; 50 Hz). The aim of the present study was evaluate individual ELF-MF during and assess eventually associated genotoxic hazard by evaluating primary DNA damage.The group comprised 21 electric welders (exposed) non-exposed control subjects (healthy blood donors). Occupational measured using personal dosimeters worn one complete work-shift (7 am 5 pm). extent damage in peripheral...
Metabolic syndrome (MetS) is a cluster of metabolic disorders that includes central obesity, hyperinsulinemia, hypercholesterolemia, hypertriglyceridemia and high blood pressure (BP). Statistical reports suggest the prevalence MetS has dramatically increased during recent years considered worldwide epidemic. been found to be associated with risk all-cause mortality, cardiovascular diseases (CVD), type 2 diabetes mellitus, chronic kidney disease some types cancer. socioeconomic cost it...