A5039257005- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Water Treatment and Disinfection
- Effects and risks of endocrine disrupting chemicals
- Chemical Analysis and Environmental Impact
- Radiation Effects and Dosimetry
- Mycotoxins in Agriculture and Food
- Liver Disease Diagnosis and Treatment
- Energy and Environment Impacts
- Wastewater Treatment and Reuse
- Hepatitis C virus research
- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Nutritional Studies and Diet
- Obesity, Physical Activity, Diet
- Environmental Education and Sustainability
- Health, Environment, Cognitive Aging
- Human Health and Disease
- Environmental Toxicology and Ecotoxicology
- Fungal Plant Pathogen Control
- Pharmaceutical Quality and Counterfeiting
- Reproductive Health and Technologies
- Pharmaceutical Economics and Policy
- Adipose Tissue and Metabolism
University of Brescia
2014-2023
Brescia University
2012-2022
The aims of this research were to study the influence peracetic acid (PAA) on formation mutagens in surface waters used for human consumption and assess its potential application disinfection drinking water. results obtained using PAA compared those found with sodium hypochlorite (NaClO) chlorine dioxide (ClO2). Ames test, root anaphase aberration assay, root/micronuclei assay Allium cepa Tradescantia/micronuclei test evaluate mutagenicity disinfected samples. Microbiological tests also...
Air pollution has been recognized as a human carcinogen. Children living in urban areas are high-risk group, because genetic damage occurring early life is considered able to increase the risk of carcinogenesis adulthood. This study aimed investigate micronuclei (MN) frequency, biomarker DNA damage, exfoliated buccal cells pre-school children town with high levels air pollution. A sample healthy 3-6-year-old Brescia, Northern Italy, was investigated. children's mucosa collected during winter...
Abstract The issue of food contamination by aflatoxins presently constitutes a social emergency, since they represent severe risk for human and animal health. On the other hand, use pesticides has to be contained, this generates long term residues in environment. Here we present synthesis series chelating ligands based on thiosemicarbazone scaffold, evaluated their antifungal antiaflatoxigenic effects. Starting from molecules natural origin known properties, introduced thio- group then...
Abstract The Allium cepa assay is an efficient test for chemical screening and in situ monitoring genotoxicity of environmental contaminants. has been used widely to study many pesticides revealing that these compounds can induce chromosomal aberrations root meristems A. cepa. Pesticide residues be present fruit vegetables represent a risk human health. mutagenic carcinogenic action herbicides, insecticides fungicides on experimental animals well known. Several studies have shown chronic...
Introduction Genotoxic biomarkers have been studied largely in adult population, but few studies so far investigated them children exposed to air pollution. Children are a high-risk group as regards the health effects of pollution and some suggest that early exposure during childhood can play an important role development chronic diseases adulthood. The objective project is evaluate associations between concentration urban pollutants biological effect children, propose model for estimating...
Macro and trace elements are important regulators of biological processes, including those ones linked to reproduction. Among them, Ca, Cu, Fe, K, Mg, Mn, Na, Se, Zn ensure normal spermatic functions. Hence, the aim this study was evaluate concentrations 26 macro (Al, As, Ba, Be, Cd, Co, Cr, Hg, Li, Ni, Pb, Rb, Sb, Sn, Sr, U, V, Zn) in blood serum also semen healthy young men, homogeneous for age, anthropometric characteristics, lifestyle, living three highly polluted areas Italy....
Abstract Disinfection of surface drinking water, in particular water chlorination, results many by‐products with potential genotoxic and/or carcinogenic activity. In the present study, we evaluated genotoxicity after treatment different disinfectants by means situ plant assays (micronucleus and chromosomal aberration tests) which can detect both clastogenic aneugenic effects. The study was carried out at a pilot using lake sedimentation filtration. This supplied four stainless steel basins:...
BackgroundWe hypothesised that the polymorphisms of genes encoding for β1- and β2-adrenoceptors may have a role in pathogenesis heart failure (HF). We therefore compared β1-adrenoceptor gene (Arg389Gly), β2-adrenoceptor (Arg16Gly, Gln27Glu) their combinations patients with HF normal subjects living same area.
Lifestyles profoundly determine the quality of an individual's health and life since his childhood. Many diseases in adulthood are avoidable if health-risk behaviors identified improved at early stage life. The aim present research was to characterize a cohort children aged 6-8 years selected order perform epidemiological molecular study (the MAPEC_LIFE study), investigate lifestyles that could have effect on their status, assess possible association between socio-cultural factors.A...
Many studies have shown the presence of numerous organic genotoxins and carcinogens in drinking water. These toxic substances derive not only from pollution, but also disinfection treatments, particularly when water is obtained surface sources then chlorinated. Most chlorinated compounds are nonvolatile difficult to characterize. Thus, it has been proposed study such complex mixtures using short-term genotoxicity tests predictive carcinogenic activity. Mutagenicity before after mainly...
Polychlorinated biphenyls (PCBs) are persistent organic pollutants produced until the 1980s, which they still present worldwide. They have been associated with metabolic and endocrine diseases hypertension in humans, but definite evidence is lacking. A chemical factory producing PCBs caused a heavy pollution an urban area Northern Italy. We aimed to evaluate serum levels according demographic lifestyle variables their associations resident general population. random sample of 816 adults aged...