A5036769741- Mercury impact and mitigation studies
- Neuropeptides and Animal Physiology
- Anesthesia and Neurotoxicity Research
- Heavy Metal Exposure and Toxicity
- Stress Responses and Cortisol
- Birth, Development, and Health
- Cell death mechanisms and regulation
- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Receptor Mechanisms and Signaling
- Neuroendocrine regulation and behavior
- Hypothalamic control of reproductive hormones
- Agricultural safety and regulations
- Neuroscience of respiration and sleep
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Neuroscience and Neuropharmacology Research
- Mycotoxins in Agriculture and Food
- Neurogenesis and neuroplasticity mechanisms
- Nitric Oxide and Endothelin Effects
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Circadian rhythm and melatonin
- Air Quality and Health Impacts
- Trace Elements in Health
- Neonatal Respiratory Health Research
Karolinska Institutet
2015-2024
European Food Safety Authority
2015
Karolinska University Hospital
2012
Society of Environmental Toxicology and Chemistry
2006-2008
Marine Environmental Analysis (Sweden)
2006
University of Parma
2003
Rockefeller University
1996
University of Pavia
1995
Stockholm University
1992
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluoroalkyl substances (PFASs) in food. Based several similar effects animals, toxicokinetics and observed concentrations blood, CONTAM Panel decided perform assessment sum four PFASs: PFOA, PFNA, PFHxS PFOS. These made up half lower bound (LB) exposure those PFASs with available occurrence data, remaining contribution being primarily from short half-lives. Equal potencies were...
The effect of intracerebroventricular injection the mitosis inhibitor colchicine and immobilization stress, subcutaneous capsaicin, intraperitoneal hypertonic salt solution on expression c-Fos-like immunoreactivity was studied in rat brain with immunohistochemistry. All procedures induced c-Fos parvocellular neurons paraventricular nucleus, many these also contained corticotropin-releasing factor immunoreactivity. observed, for example, subpopulations locus coeruleus, ventrolateral medulla...
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA) in food. Regarding PFOS PFOA occurrence, final data set available dietary exposure assessment contained total 20,019 analytical results (PFOS n = 10,191 9,828). There were large differences between upper lower bound due methods with insufficient sensitivity. CONTAM Panel considered estimates be closer true levels....
Deoxynivalenol (DON) is a mycotoxin primarily produced by Fusarium fungi, occurring predominantly in cereal grains. Following the request of European Commission, CONTAM Panel assessed risk to animal and human health related DON, 3-acetyl-DON (3-Ac-DON), 15-acetyl-DON (15-Ac-DON) DON-3-glucoside food feed. A total 27,537, 13,892, 7,270 2,266 analytical data for 3-Ac-DON, 15-Ac-DON DON-3-glucoside, respectively, food, feed unprocessed grains collected from 2007 2014 were used. For exposure,...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of dioxins (PCDD/Fs) DL-PCBs in feed food. data from experimental epidemiological studies were reviewed it was decided base risk assessment effects observed humans use as supportive evidence. critical effect semen quality, following pre- postnatal exposure. study showed NOAEL 7.0 pg WHO
Zearalenone (ZEN), a mycotoxin primarily produced by Fusarium fungi, occurs predominantly in cereal grains.The European Commission asked EFSA for scientific opinion on the risk to animal health related ZEN and its modified forms feed.Modified of occurring feed include phase I metabolites a-zearalenol (a-ZEL), b-zearalenol (b-ZEL), a-zearalanol (a-ZAL), b-zearalanol (b-ZAL), zearalanone (ZAN) II conjugates.ZEN has oestrogenic activity differs considerably.For ZEN, Panel Contaminants Food...
EFSA was asked by the European Commission to deliver a scientific opinion on risks for human health related presence of pyrrolizidine alkaloids (PAs) in honey, tea, herbal infusions and food supplements identify PAs relevance aforementioned commodities other feed food. are large group toxins produced different plant species. In 2011, Panel Contaminants Food Chain (CONTAM Panel) assessed feed. Based occurrence data limited CONTAM concluded that there possible concern those toddlers children...
By using immunohistochemistry and in situ hybridization, we have demonstrated that the nitric oxide (NO)-synthesizing enzyme NO synthase is present gonadotrophs folliculo-stellate cells of anterior pituitary gland male female rats. A marked increase levels protein mRNA was observed after gonadectomy. In vitro studies on dispersed suggest inhibits gonadotropin-releasing-hormone-stimulated luteinizing hormone release. An inhibitory effect has also been shown...
Substantial evidence indicates that predisposition to diseases can be acquired during early stages of development and interactions between environmental genetic factors may implicated in the onset many pathological conditions. Data collected over several decades have shown chemicals are among relevant endanger CNS. We previously showed perinatal exposure methylmercury (MeHg) causes persistent changes learning motivational behavior mice. In this study, we report depression-like MeHg-exposed...
Abstract The axonal transport blocker clochicine has been extensively used in immunohistochemical studies to induce accumulation of neuroactive compounds, especially neuropeptides, neuronal somata and thus improve their visualization. To assess whether colchicine might, addition, ifluence the synthesis such we have now situ hybridization examine level mRNAs encoding for several neuropeptides (galanin[GAL], cholecystokinn [CCK], somatostatin [sOM], neuropeptide Y[NPY])...
Abstract Neural stem cells (NSCs) play an essential role in both the developing embryonic nervous system through to adulthood where capacity for self‐renewal may be important normal function of CNS, such as learning, memory and response injury. There has been much excitement about possibility transplantation NSCs replace damaged or lost neurones, by recruitment endogenous precursors. However, before full potential can realized, it is understand physiological pathways that control their...
To investigate the long-term effects of developmental exposure to methylmercury (MeHg), pregnant mice were exposed at 0.5 mg MeHg/kg/day via drinking water from gestational day 7 until after delivery. The behavior offspring was monitored 5–15 and 26–36 weeks age using an automated system (IntelliCage) designed for continuous recording home cage in social groups complex analysis basic activities learning. In addition, spontaneous locomotion, motor coordination on accelerating rotarod, spatial...
The distribution of several peptides, corticotropin-releasing factor (CRF), neurotensin (NT), enkephalin (ENK), vasoactive intestinal polypeptide (VIP), peptide histidine isoleucine (PHI), cholecystokinin (CCK), thyrotropin-releasing hormone (TRH) and galanin (GAL) was studied in detail with immunohistochemistry the various subdivisions parvocellular part rat hypothalamic paraventricular nucleus (PVN). Using a double-staining method elution-restaining technique, coexistence CRF- NT-like...
Tetrodotoxin (TTX) and its analogues are produced by marine bacteria have been detected in bivalves gastropods from European waters. The Commission asked EFSA for a scientific opinion on the risks to public health related presence of TTX gastropods. Panel Contaminants Food Chain reviewed available literature but did not find support minimum lethal dose humans 2 mg, mentioned various reviews. Some human case reports describe serious effects at 0.2 corresponding 4 μg/kg body weight (bw)....