A5073305642- Polyamine Metabolism and Applications
- Amino Acid Enzymes and Metabolism
- Agricultural safety and regulations
- Cannabis and Cannabinoid Research
- Effects and risks of endocrine disrupting chemicals
- Pesticide Residue Analysis and Safety
- Mycotoxins in Agriculture and Food
- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Biopolymer Synthesis and Applications
- Metabolism and Genetic Disorders
- DNA and Nucleic Acid Chemistry
- Cancer Research and Treatments
- Epigenetics and DNA Methylation
- Chromium effects and bioremediation
- Cassava research and cyanide
- Protein Hydrolysis and Bioactive Peptides
- Melamine detection and toxicity
- Bioactive Natural Diterpenoids Research
- Trace Elements in Health
- Per- and polyfluoroalkyl substances research
- Botanical Research and Chemistry
- Plant-based Medicinal Research
- Animal testing and alternatives
- Animal Ecology and Behavior Studies
National Health Service Scotland
2024
Institute of Medical Sciences
2016-2024
University of Aberdeen
2014-2023
Grand Valley State University
2019-2023
Australian Catholic University
2022-2023
Lexington VA Health Care System
2023
Istituto Superiore di Sanità
2020
Lund University
2015
Nutrition Sciences (Belgium)
2015
Gonzaga University
2013-2014
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluoroalkyl substances (PFASs) in food. Based several similar effects animals, toxicokinetics and observed concentrations blood, CONTAM Panel decided perform assessment sum four PFASs: PFOA, PFNA, PFHxS PFOS. These made up half lower bound (LB) exposure those PFASs with available occurrence data, remaining contribution being primarily from short half-lives. Equal potencies were...
The European Commission asked EFSA for a scientific evaluation on the risks to human health related presence of perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic (PFOA) in food. Regarding PFOS PFOA occurrence, final data set available dietary exposure assessment contained total 20,019 analytical results (PFOS n = 10,191 9,828). There were large differences between upper lower bound due methods with insufficient sensitivity. CONTAM Panel considered estimates be closer true levels....
EFSA was asked to deliver a scientific opinion on the risks public health related presence of aflatoxins in food. The risk assessment confined aflatoxin B1 (AFB1), AFB2, AFG1, AFG2 and AFM1. More than 200,000 analytical results occurrence were used evaluation. Grains grain-based products made largest contribution mean chronic dietary exposure AFB1 all age classes, while 'liquid milk' 'fermented milk products' main contributors AFM1 exposure. Aflatoxins are genotoxic can cause hepatocellular...
The European Commission asked EFSA to update their 2006 opinion on ochratoxin A (OTA) in food. OTA is produced by fungi of the genus
The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step-by-step instructions TTC approach. inclusion exclusion criteria are defined decision tree explained. approach can be used when chemical structure substance known, there limited chemical-specific toxicity data exposure estimated. should not substances which EU food/feed legislation requires...
EFSA was asked by the European Commission to deliver a scientific opinion on risks for human health related presence of pyrrolizidine alkaloids (PAs) in honey, tea, herbal infusions and food supplements identify PAs relevance aforementioned commodities other feed food. are large group toxins produced different plant species. In 2011, Panel Contaminants Food Chain (CONTAM Panel) assessed feed. Based occurrence data limited CONTAM concluded that there possible concern those toddlers children...
The European Commission asked EFSA to update its previous Opinion on nickel in food and drinking water, taking into account new occurrence data, the updated benchmark dose (BMD) Guidance newly available scientific information.More than 47,000 analytical results of were used for calculating chronic acute dietary exposure.An increased incidence postimplantation loss rats was identified as critical effect risk characterisation oral exposure a BMDL 10 1.3 mg Ni/kg body weight (bw) per day...
EFSA was asked for a scientific opinion on the risks to public health related presence of
The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard of inorganic (iAs) and using the revised exposure issued by 2021. Epidemiological studies show that chronic intake iAs via diet and/or drinking water is associated with increased several adverse outcomes including cancers skin, bladder lung. CONTAM Panel used benchmark dose lower confidence limit based response (BMR) 5% (relative increase background incidence after adjustment for...
The European Commission asked EFSA to update its 2011 risk assessment on tetrabromobisphenol A (TBBPA) and five derivatives in food. Neurotoxicity carcinogenicity were considered as the critical effects of TBBPA rodent studies. available evidence indicates that occurs via non-genotoxic mechanisms. Taking into account new data, CONTAM Panel it appropriate set a tolerable daily intake (TDI). Based decreased interest social interaction male mice, lowest observed adverse effect level (LOAEL) 0.2...
Tetrodotoxin (TTX) and its analogues are produced by marine bacteria have been detected in bivalves gastropods from European waters. The Commission asked EFSA for a scientific opinion on the risks to public health related presence of TTX gastropods. Panel Contaminants Food Chain reviewed available literature but did not find support minimum lethal dose humans 2 mg, mentioned various reviews. Some human case reports describe serious effects at 0.2 corresponding 4 μg/kg body weight (bw)....
The CONTAM Panel updated the assessment of risks for human health related to presence 3-monochloropropane diol (3-MCPD) and its fatty acid esters in food published 2016 view scientific divergence identified establishment tolerable daily intake (TDI) Joint FAO/WHO Expert Committee on Food Additives Contaminants (FAO/WHO) report 2017.In this update, dose-response analysis was performed following recent EFSA Scientific guidance use benchmark dose (BMD) approach risk assessment, a review...
The EFSA Panel on Contaminants in the Food Chain (CONTAM) established a tolerable daily intake (TDI) for fumonisin B
COVID-19 pandemic mitigation strategies are mainly based on social distancing measures and healthcare system reinforcement. However, many countries in Europe elsewhere implemented strict, horizontal lockdowns because of extensive viral spread the community which challenges capacity systems. strict have various untintended adverse social, economic health effects, yet to be fully elucidated, not been considered models examining effects measures. Unlike commonly suggested, dilemma is about vs...
Fumonisins, mycotoxins primarily produced by Fusarium verticillioides and proliferatum, occur predominantly in cereal grains, especially maize. The European Commission asked EFSA for a scientific opinion on the risk to animal health related fumonisins their modified hidden forms feed. Fumonisin B1 (FB 1), FB 2 3 are most common of feedstuffs thus were included assessment. 1, have same mode action considered as having similar toxicological profile potencies. For fumonisins, Panel Contaminants...
In 2016, the EFSA Panel on Contaminants in Food Chain (CONTAM) published a scientific opinion acute health risks related to presence of cyanogenic glycosides (CNGs) raw apricot kernels which an reference dose (ARfD) 20 μg/kg body weight (bw) was established for cyanide (CN). present opinion, CONTAM concluded that this ARfD is applicable effects CN regardless dietary source. To account differences bioavailability after ingestion certain food items, specific factors were used. Estimated mean...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of quinolizidine alkaloids (QAs) in feed food. This risk assessment is limited QAs occurring Lupinus species/varieties relevant consumption Europe (i.e. albus L., angustifolius luteus L. mutabilis Sweet). Information toxicity animals humans limited. Following acute exposure sparteine (reference compound), anticholinergic effects changes cardiac electric conductivity are...
The European Commission asked EFSA for a scientific opinion on the risks animal and human health related to presence of chlorinated paraffins in feed food. data experimental animals were reviewed CONTAM Panel identified liver, kidney thyroid as target organs SCCP MCCP mixtures tested repeated dose toxicity studies. Decreased pup survival subcutaneous haematoma/haemorrhage also critical effects an mixture. For LCCP tested, liver was organ. selected reference points BMDL 10 2.3 mg/kg bw per...
In 2018, the EFSA Panel on Contaminants in Food Chain (CONTAM) adopted a Scientific Opinion risks for animal health related to presence of fumonisins, their modified forms and hidden feed. A no observed adverse effect level (NOAEL) 1 mg/kg feed was established pigs. poultry NOAEL 20 horses reference point 8.8 established, referred as NOAEL. The European Commission (EC) requested review information regarding toxicity fumonisins pigs, revise, if necessary, NOAELs. CONTAM considered that term...
Abstract The European Commission requested EFSA to provide an update of the 2012 Scientific Opinion Panel on Contaminants in Food Chain (CONTAM) risks for animal health related presence ergot alkaloids (EAs) feed. EAs are produced by several fungi Claviceps and Epichloë genera. This focussed 14 C. purpurea (ergocristine, ergotamine, ergocornine, α- β-ergocryptine, ergometrine, ergosine their corresponding 'inine' epimers). Effects observed with from africana (mainly dihydroergosine)...
Abstract EFSA was asked for a scientific opinion on the risks animal and human health related to presence of polychlorinated naphthalenes (PCNs) in feed food. The assessment focused hexaCNs due very limited data other PCN congeners. For feed, 217 analytical results were used estimate dietary exposures food-producing non-food-producing animals; however, risk characterisation could not be performed because none toxicological studies allowed identification reference points. oral repeated dose...