A5043106486- Agricultural safety and regulations
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Pharmaceutical studies and practices
- Pharmacogenetics and Drug Metabolism
- Pesticide Residue Analysis and Safety
- Consumer Attitudes and Food Labeling
- Antibiotics Pharmacokinetics and Efficacy
- Drug Transport and Resistance Mechanisms
- Animal testing and alternatives
- Analytical Methods in Pharmaceuticals
- Pesticide Exposure and Toxicity
- Occupational exposure and asthma
- Analytical Chemistry and Chromatography
- Aluminum toxicity and tolerance in plants and animals
- Food composition and properties
- Pharmacovigilance and Adverse Drug Reactions
- Vitamin K Research Studies
- Genetically Modified Organisms Research
- Biochemical Analysis and Sensing Techniques
- Computational Drug Discovery Methods
- Toxic Organic Pollutants Impact
- Drug-Induced Hepatotoxicity and Protection
- Heavy Metal Exposure and Toxicity
- Risk and Safety Analysis
Charité - Universitätsmedizin Berlin
2014-2023
Freie Universität Berlin
1999-2023
Humboldt-Universität zu Berlin
2019-2023
Federal Institute for Risk Assessment
2010-2022
Berlin Institute of Health at Charité - Universitätsmedizin Berlin
2019
Arzneimittelkommission der deutschen Ärzteschaft
2009-2018
MSB Medical School Berlin
2018
German Medical Association
2011-2018
University of Zurich
2017
PharmacoGenetics (China)
2016
The Scientific Committee (SC) reconfirms that the benchmark dose (BMD) approach is a scientifically more advanced method compared to NOAEL for deriving Reference Point (RP). Most of modifications made SC guidance 2009 concern section providing on how apply BMD approach. Model averaging recommended as preferred calculating confidence interval, while acknowledging respective tools are still under development and may not be easily accessible all. Therefore, selecting or rejecting models...
The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step-by-step instructions TTC approach. inclusion exclusion criteria are defined decision tree explained. approach can be used when chemical structure substance known, there limited chemical-specific toxicity data exposure estimated. should not substances which EU food/feed legislation requires...
The EFSA ANS Panel was asked to provide a scientific opinion on the safety of green tea catechins from dietary sources including preparations such as food supplements and infusions.Green is produced leaves Camellia sinensis (L.) Kuntze, without fermentation, which prevents oxidation polyphenolic components.Most polyphenols in are catechins.The considered possible association between consumption (-)-epigallocatechin-3-gallate (EGCG), most relevant catechin tea, hepatotoxicity.This based...
In 2015, EFSA established a temporary tolerable daily intake (t-TDI) for BPA of 4 μg/kg body weight (bw) per day. 2016, the European Commission mandated to re-evaluate risks public health from presence in foodstuffs and establish (TDI). For this re-evaluation, pre-established protocol was used that had undergone consultation. The CEP Panel concluded it is Unlikely Very presents genotoxic hazard through direct mechanism. Taking into consideration evidence animal data support human...
The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by Panel to be reliable, including data obtained TiO
Following a request from the European Commission to EFSA, EFSA Scientific Committee (SC) prepared guidance for risk assessment of substances present in food intended infants below 16 weeks age.In its approach develop this guidance, SC took into account, among others, (i) an exposure based on infant formula as only source nutrition; (ii) knowledge organ development human infants, including gut, metabolic and excretory capacities, brain barriers, immune system, endocrine reproductive systems;...
The EFSA Panel on Food Additives and Nutrient Sources added to (ANS) provides a scientific opinion re-evaluating the safety of silicon dioxide (E 551) when used as food additive. forms synthetic amorphous silica (SAS) E 551 include fumed hydrated (precipitated silica, gel hydrous silica). Scientific Committee (SCF) established group acceptable daily intake (ADI) 'not specified' for silicates. SAS materials in available biological toxicological studies were different their physicochemical...
The present opinion deals with the re-evaluation of safety food-grade carrageenan (E 407) and processes Eucheuma seaweed 407a) used as food additives. Because structural similarities, Panel concluded that processed can be included in evaluation carrageenan. Poligeenan (average molecular weight 10-20 kDa) has not been authorised a additive is any applications. In its 407a), noted ADME database was sufficient to conclude absorbed intact; subchronic toxicity study performed almost complying EU...
The Panel on Food Additives and Nutrient Sources added to (ANS) provided a scientific opinion re-evaluating the safety of potassium nitrite (E 249) sodium 250) when used as food additives. ADIs established by SCF (1997) JECFA (2002) for were 0-0.06 0-0.07 mg/kg bw per day, respectively. available information did not indicate
The Panel on Food Additives and Nutrient Sources added to (ANS) provided a scientific opinion re-evaluating the safety of sodium nitrate (E 251) potassium 252) when used as food additives. current acceptable daily intakes (ADIs) for 3.7 mg/kg body weight (bw) per day were established by SCF (1997) JECFA (2002). available data did not indicate genotoxic potential nitrate. carcinogenicity studies in mice rats negative. considered derivation an ADI based formation methaemoglobin, following...
The Panel on Food Additives and Flavourings added to (FAF) provided a scientific opinion re-evaluating the safety of phosphates (E 338-341, E 343, 450-452) as food additives. considered that adequate exposure toxicity data were available. Phosphates are authorised additives in EU accordance with Annex II III Regulation (EC) No 1333/2008. Exposure from whole diet was estimated using mainly analytical data. values ranged 251 mg P/person per day infants 1,625 for adults, high (95th percentile)...
Drug-induced liver injury (DILI) cannot be accurately predicted by animal models. In addition, currently available in vitro methods do not allow for the estimation of hepatotoxic doses or determination an acceptable daily intake (ADI). To overcome this limitation, vitro/in silico method was established that predicts risk human DILI relation to oral and blood concentrations. This can used estimate if maximal concentration (Cmax) test compound is known. Moreover, ADI estimated even compounds...
The Panel on Food Additives and Nutrient Sources added to (ANS) was asked deliver a scientific opinion the safety of monacolins in red yeast rice (RYR) provide advice dietary intake that does not give rise concerns about harmful effects health. reviewed evidences available as well information provided by interested parties response public 'Call for data' launched EFSA. considered monacolin K lactone form is identical lovastatin, active ingredient several medicinal products authorised...
The present scientific opinion deals with the evaluation of safety nisin (E 234) in light new toxicological data and proposed extension use unripened cheese heat-treated meat products. Nisin is currently an authorised food additive EU under Annex II Regulation (EC) 1333/2008 for several categories. as a has been evaluated 2006 by EFSA Panel on Food Additives, Flavourings, Processing Aids Materials Contact Food, where acceptable daily intake (ADI) 0.13 mg/kg body weight (bw) was confirmed...