A5076342508- Agricultural safety and regulations
- Pesticide Residue Analysis and Safety
- Pesticide Exposure and Toxicity
- Insect and Pesticide Research
- Bee Products Chemical Analysis
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Plant and animal studies
- Pesticide and Herbicide Environmental Studies
- Environmental Toxicology and Ecotoxicology
- Chemical Safety and Risk Management
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Toxic Organic Pollutants Impact
- Insect and Arachnid Ecology and Behavior
- Animal testing and alternatives
- Genetically Modified Organisms Research
- Essential Oils and Antimicrobial Activity
- Plant Surface Properties and Treatments
- Insect Resistance and Genetics
- Analytical chemistry methods development
- Contact Dermatitis and Allergies
- Pharmacological Effects and Assays
- Marine Biology and Environmental Chemistry
- Mycotoxins in Agriculture and Food
Benaki Phytopathological Institute
2016-2025
University of Zurich
2023
Environmental Protection Agency
2018
Durham University
2018
Pension Fund for Care and Well-Being
2018
Federal Institute for Risk Assessment
2018
The Scientific Committee confirms that the Threshold of Toxicological Concern (TTC) is a pragmatic screening and prioritisation tool for use in food safety assessment. This Guidance provides clear step-by-step instructions TTC approach. inclusion exclusion criteria are defined decision tree explained. approach can be used when chemical structure substance known, there limited chemical-specific toxicity data exposure estimated. should not substances which EU food/feed legislation requires...
The EFSA has updated the Guidance on risk assessment of application nanoscience and nanotechnologies in food feed chain, human animal health. It covers areas within EFSA's remit, including novel foods, contact materials, food/feed additives pesticides. guidance, now Scientific Committee nano (SC Nano-RA), taken account relevant scientific studies that provide insights to physico-chemical properties, exposure hazard characterisation nanomaterials applicability. Together with accompanying...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion science behind risk assessment of plant protection products for in-soil organisms.The current scheme is reviewed, taking into account new regulatory frameworks scientific developments.Proposals are made specific goals organisms being key drivers relevant ecosystem services in agricultural landscapes such as nutrient cycling, soil structure, pest control biodiversity.Considering...
This guidance on the assessment of dermal absorption has been developed to assist notifiers, users test facilities and Member State authorities critical aspects related setting values be used in risk assessments active substances Plant Protection Products (PPPs).It is based 'scientific opinion science behind revision document absorption' issued 2011 by EFSA Panel their Residues (PPR).The refers PPR many instances.In addition, first version this guidance, 2012 Panel, revised 2017 basis new...
Following a mandate from the European Commission, EFSA has developed Guidance on Technical Requirements (Guidance Particle-TR), defining criteria for assessing presence of fraction small particles, and setting out information requirements applications in regulated food feed product areas (e.g. novel food, food/feed additives, contact materials pesticides). These apply to particles requiring specific assessment at nanoscale conventional that do not meet definition engineered nanomaterial as...
The Scientific Committee (SC) reconfirms that the benchmark dose (BMD) approach is a scientifically more advanced method compared to no-observed-adverse-effect-level (NOAEL) for deriving Reference Point (RP). major change previous Guidance (EFSA SC, 2017) concerns Section 2.5, in which from frequentist Bayesian paradigm recommended. In former, uncertainty about unknown parameters measured by confidence and significance levels, interpreted calibrated under hypothetical repetition, while...
Copper is an essential micronutrient and also a regulated product used in organic conventional farming pest management. Both deficiency excessive exposure to copper can have adverse health effects. In this Scientific Opinion, the EFSA 2021 harmonised approach for establishing health-based guidance values (HBGVs) substances that are products nutrients was resolve divergent existing HBGVs copper. The tightly homeostasis prevents toxicity manifestation short term, but development of chronic...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues (PPR) developed an opinion state of art Toxicokinetic/Toxicodynamic (TKTD) models use in prospective environmental risk assessment (ERA) for pesticides aquatic organisms. TKTD are species- compound-specific can be used to predict (sub)lethal effects under untested (time-variable) exposure conditions. Three different types described, viz., (i) 'General Unified Threshold Survival' (GUTS), (ii) those based...
This guidance document provides harmonised and flexible methodologies to apply scientific criteria prioritisation methods for grouping chemicals into assessment groups human risk of combined exposure multiple chemicals. In the context EFSA’s assessments, problem formulation step defines be assessed in terms reference usually through regulatory often set by managers based on legislative requirements. Scientific such as hazard-driven can used group these groups. this document, a framework is...
Bees encounter a plethora of environmental contaminants during nectar and pollen collection from plants. Consequently, after their entrance into the beehives, transfer numerous pollutants to apicultural products is inevitable.
Propolis is a bee product that has been extensively used in alternative medicine and recently gained interest on global scale as an essential ingredient of healthy foods cosmetics. also considered to improve human health prevent diseases such inflammation, heart disease, diabetes even cancer. However, the claimed effects are anticipated be correlated its chemical composition. Since propolis natural product, composition consequently expected variable depending local flora alignment. In this...
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion science to support potential development of risk assessment scheme plant protection products for amphibians reptiles. The coverage reptiles by current assessments other vertebrate groups was investigated. Available test methods exposure models were reviewed with regard applicability Proposals made specific goals aiming protect important ecosystem services taking into consideration...
Triadimefon is a widely used triazole fungicide known to cause severe developmental defects in several model organisms and humans. The present study evaluated detail the effects seen zebrafish embryos exposed triadimefon, confirmed expanded upon previous phenotypic findings compared them those observed other traditional animal models. In order do this, we 2 4 µg/mL triadimefon growth until 120 h post-fertilization (hpf) through gross morphology examination. Our analysis revealed significant...
Adverse outcome pathways (AOPs) describe causal relationships between molecular perturbation and adverse cellular effects are being increasingly adopted for linking in vitro mechanistic toxicology to vivo data from regulatory toxicity studies. In this work, a case study was performed by developing bioassay toolbox assess key events the recently proposed AOP chemically induced liver steatosis. The is comprised of assays measure nuclear receptor activation, gene protein expression, lipid...
The EFSA Scientific Committee was asked to provide guidance on the most appropriate
The European Parliament requested EFSA to develop a holistic risk assessment of multiple stressors in honey bees. To this end, systems-based approach that is composed two core components: monitoring system and modelling are put forward with bees taken as showcase. Key developments the current scientific opinion (including systematic data collection from sentinel beehives an agent-based simulation) have potential substantially contribute future development environmental assessments at larger...
This Statement presents a proposal for harmonising the establishment of Health-Based Guidance Values (HBGVs) regulated products that are also nutrients.This is recurrent issue food additives and pesticides, may occasionally occur other products.The describes specific considerations should be followed establishing HBGVs during assessment product nutrient.It addresses elements to considered in intake assessment; proposes decision tree ensuring harmonised process risk characterisation...
This Opinion assesses the biological relevance of non-monotonic dose responses (NMDR) identified in a previous EFSA External Report (Beausoleil et al., 2016) produced under GP/EFSA/SCER/2014/01 and follow-up probabilistic assessment (Chevillotte 2017a,b), focusing on
The EFSA Scientific Committee has updated its 2010 Guidance on risk-benefit assessment (RBA) of foods. update addresses methodological developments and regulatory needs. While it retains the stepwise RBA approach, provides additional methods for complex assessments, such as multiple chemical hazards all relevant health effects impacting different population subgroups. guidance includes approaches systematic identification, prioritisation selection hazardous beneficial food components. It...