A5024594871- Agricultural safety and regulations
- Pesticide Residue Analysis and Safety
- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Genetically Modified Organisms Research
- Vitamin K Research Studies
- DNA Repair Mechanisms
- Genetic factors in colorectal cancer
- Pesticide Exposure and Toxicity
- Consumer Attitudes and Food Labeling
- Animal Nutrition and Physiology
- Occupational exposure and asthma
- Pharmaceutical studies and practices
- Insect and Pesticide Research
- Coccidia and coccidiosis research
- Cancer Genomics and Diagnostics
- Insect Resistance and Genetics
- Epigenetics and DNA Methylation
- Pharmaceutical Economics and Policy
- Biochemical Analysis and Sensing Techniques
- Dye analysis and toxicity
- DNA and Nucleic Acid Chemistry
- Animal Ecology and Behavior Studies
- Food Allergy and Anaphylaxis Research
- Trace Elements in Health
Istituto Superiore di Sanità
1998-2022
Cepsa (Spain)
2020
The Honourable Society of Lincoln's Inn
1993
[Table: see text].This guidance document is intended to assist the applicant in preparation and presentation of an application, as foreseen Article 7.6 Regulation (EC) No 1831/2003, for authorisation additives use animal nutrition. It specifically covers characterisation microorganisms used feed or production organisms.
[Table: see text].This guidance document is intended to assist the applicant in preparation and presentation of an application, as foreseen Article 7.6 Regulation (EC) No 1831/2003, for authorisation additives use animal nutrition. It specifically covers assessment safety target species.
[Table: see text].This guidance document is intended to assist the applicant in preparation and presentation of an application, as foreseen Article 7.6 Regulation (EC) No 1831/2003, for authorisation additives use animal nutrition. It specifically covers assessment safety consumer.
Draft Endorsed by the FEEDAP Panel 16 May 2017 Submitted for public consultation 24 End of 7 July Adoption 27 September Entry into force 1 2018 Abstract This guidance document is intended to assist applicant in preparation and presentation an application, as foreseen Article 7.6 Regulation (EC) No 1831/2003, authorisation additives use animal nutrition. It specifically covers identity, characterisation conditions additives.
The present opinion deals with an updated safety assessment of the food additive titanium dioxide (E 171) based on new relevant scientific evidence considered by Panel to be reliable, including data obtained TiO
The EFSA Scientific Committee addressed in this document the peculiarities related to genotoxicity assessment of chemical mixtures. suggests that first a mixture should be chemically characterised as far possible. Although characterisation mixtures is relevant also for other toxicity aspects, it particularly significant genotoxicity. If contains one or more substances are individually assessed genotoxic
The European Commission requested EFSA to provide advice on the following: (1) suitability of unscheduled DNA synthesis (UDS)
The Panel on Food Additives and Flavourings added to (FAF) provided a scientific opinion re-evaluating the safety of phosphates (E 338-341, E 343, 450-452) as food additives. considered that adequate exposure toxicity data were available. Phosphates are authorised additives in EU accordance with Annex II III Regulation (EC) No 1333/2008. Exposure from whole diet was estimated using mainly analytical data. values ranged 251 mg P/person per day infants 1,625 for adults, high (95th percentile)...
Oxidation is a common form of DNA damage to which purines are particularly susceptible. We previously reported that oxidized dGTP potentially an important source 8-oxodGMP in mammalian cells and the incorporated lesions removed by mismatch repair (MMR). MMR deficiency associated with mutator phenotype widespread microsatellite instability (MSI). Here, we identify deoxynucleoside triphosphates (dNTPs) as cofactor this genetic instability. The high spontaneous hprt mutation rate MMR-defective...
The EFSA Scientific Committee was asked to provide guidance on the most appropriate
Following a request from the European Commission, Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver scientific opinion sodium carboxymethyl cellulose as feed additive for all animal species. Sodium is intended use technological (functional groups: emulsifier, stabiliser, thickener, gelling agent binder) premixtures feedingstuffs species with no minimum maximum content. A proper identification characterisation of required not available occurrence...
Abstract Sulfur dioxide–sulfites (E 220–228) were re-evaluated in 2016, resulting the setting of a temporary ADI 0.7 mg SO2 equivalents/kg bw per day. Following European Commission call for data, present follow-up opinion assesses data provided by interested business operators (IBOs) and additional evidence identified publicly available literature. No new biological or toxicological addressing gaps described re-evaluation submitted IBOs. Taking into account from literature search, Panel...
Abstract Citric acid esters of mono‐ and diglycerides fatty acids (E 472c) was re‐evaluated in 2020 by the Food Additives Flavourings Panel (FAF Panel) along with acetic acid, lactic tartaric diacetyltartaric mixed 472a,b,d,e,f). As a follow‐up to this assessment, FAF requested assess safety citric for its use as food additive infants below 16 weeks age belonging categories (FCs) 13.1.1 (Infant formulae defined Directive 2006/141/EC) 13.1.5.1 (Dietary foods special medical purposes infants)....
Abstract The Panel on Food Additives and Flavourings (FAF) provides a scientific opinion re‐evaluating the safety of butane (E 943a), isobutane 943b) propane 944) as food additives. Butane, are short‐chain (C3–C4) alkanes, which in gaseous state at room temperature. Their currently permitted use is vegetable oil pan spray (for professional only) water‐based emulsion propellants quantum satis. They can also be used colour preparations with maximum residual limit 1 mg/kg food. Two interested...
Abstract The EFSA Panel on Food Additives and Flavourings (FAF) was requested to evaluate the safety of 3‐[3‐(2‐isopropyl‐5‐methyl‐cyclohexyl)‐ureido]‐butyric acid ethyl ester [FL‐no: 16.136] as a new flavouring substance, in accordance with Regulation (EC) No 1331/2008. substance has not been reported occur naturally it is chemically synthesised. information provided manufacturing process, composition stability considered sufficient. chronic dietary exposure estimated using added portions...
Abstract The EFSA Panel on Food Additive and Flavourings (FAF Panel) provides a scientific opinion the safety assessment of proposed use pea fibre concentrate (FIPEA) as food additive. FIPEA is powder consisting mainly dietary fibres (i.e. pectin hemicellulose), low amounts protein, derived from yellow (P. sativum). manufacturing process includes extensive heat treatments, (e.g. > 100°C for more than 40 min), conditions which lead to inactivation lectins, that in do not pose concern. A...
Abstract The present opinion deals with the re‐evaluation of pullulan (E 1204) when used as a food additive and new application on extension use to several categories. Pullulan is obtained by fermentation food‐grade hydrolysed starch non‐genetically modified Aureobasidium pullulans ■■■■■. Based available information, Panel considered that manufacturing process using this microorganism does not raise safety concern. confirmed no concern for genotoxicity. In vitro, broken down salivary...
Following a request from the European Commission, EFSA was asked to deliver scientific opinion on safety and efficacy of feed additive consisting chromium chelate DL-methionine (Availa® Cr) for salmonids. The Panel Additives Products or Substances used in Animal Feed (FEEDAP) concluded that is safe salmonids at maximum recommended 600 mg additive/kg complete (corresponding 0.6 Cr/kg feed). use animal considered consumers environment. not an eye nor skin irritant. Due presence nickel,...
We have analyzed spontaneous mutations in the adenine phosphoribosyltransferase gene of Chinese hamster clone B cells that exhibit a mutator phenotype because defective mismatch binding. The conferred increases limited number mutational classes. rates transitions and most transversions were not significantly increased. A to T -2 frameshifts strikingly elevated. These repeated elements 5 9 dinucleotide deletions DNA sequences resembling microsatellites. binding protein is line G-T recognition...