A5073550275- Carcinogens and Genotoxicity Assessment
- Dye analysis and toxicity
- Angiogenesis and VEGF in Cancer
- Effects and risks of endocrine disrupting chemicals
- Agricultural safety and regulations
- Biochemical Analysis and Sensing Techniques
- Consumer Attitudes and Food Labeling
- Pesticide Exposure and Toxicity
- Proteoglycans and glycosaminoglycans research
- Pancreatic function and diabetes
- Advanced Chemical Sensor Technologies
- Cell Adhesion Molecules Research
- Ethics in Clinical Research
- Aortic aneurysm repair treatments
- Interprofessional Education and Collaboration
- Fibroblast Growth Factor Research
- Healthcare Systems and Technology
- Molten salt chemistry and electrochemical processes
- Ginger and Zingiberaceae research
- Synthetic Organic Chemistry Methods
- Analytical chemistry methods development
- Vitamin C and Antioxidants Research
- Paraoxonase enzyme and polymorphisms
- Radioactive element chemistry and processing
- Plant biochemistry and biosynthesis
European Food Safety Authority
2022-2023
Organization of American States
2018-2021
American Chemistry Council
2014-2020
Color (United States)
2016-2019
General Hospital of Nikea
2019
University Hospital of Alexandroupolis
2019
In-Q-Tel
2018
Federal Emergency Management Agency
2015
Aptevo Therapeutics (United states)
2014
University of Thessaly
2013
Copper is an essential micronutrient and also a regulated product used in organic conventional farming pest management. Both deficiency excessive exposure to copper can have adverse health effects. In this Scientific Opinion, the EFSA 2021 harmonised approach for establishing health-based guidance values (HBGVs) substances that are products nutrients was resolve divergent existing HBGVs copper. The tightly homeostasis prevents toxicity manifestation short term, but development of chronic...
Several methods for the in vivo study of angiogenesis are available, and each angiogenic assay presents distinct advantages disadvantages. In this study, we present a new method quantitation antiangiogenesis chick embryo chorioallantoic membrane (CAM), based on implantation gelatin sponges top growing CAM, day 8 incubation. After implantation, were treated with stimulator (recombinant human basic fibroblast growth factor, FGF2) or an inhibitor (a rabbit polyclonal anti-FGF2 antibody) blood...
This study examined the association between genetic polymorphisms and enzyme activity for antioxidant enzymes that share a common detoxification pathway: manganese superoxide dismutase (MnSOD), glutathione peroxidase-1 (GPX1) catalase.MnSOD, GPX1, catalase activities were measured in isolated erythrocytes of 231 healthy, non-smoking student volunteers (55% women, ages 17-21, majority Asian or Caucasian). DNA from blood clots was genotyped by Taqman PCR (C47T : MnSOD C593T GPX1) standard...
Recent studies have demonstrated widespread pesticide exposures in pregnant women and children. Plasma paraoxonase 1 (PON1) plays an important role detoxification of various organophosphates. The goals this study were to examine the Center for Health Assessment Mothers Children Salinas (CHAMACOS) birth cohort Latina mothers their newborns living Valley, California, frequencies five PON1 polymorphisms coding region (192QR 55LM) promoter (−162AG, −909CG, −108CT) determine associations with...
Abstract The mouse is the most commonly used species for in vivo studies on angiogenesis related to tumor development. Yet, best of our knowledge, very few reports vitro interaction angiogenic basic fibroblast growth factor (bFGF) with endothelial cells are available. Three cell lines originated from aorta (MAECs), brain capillaries (MBECs), and heart (MHECs) were characterized phenotypic markers, tumorigenic activity, capacity respond bFGF. These express angiotensin-converting enzyme,...
The metabolic fate of a compound is determined by numerous factors including its chemical structure. Although the options for variety functional groups are well understood and can often provide rationale comparison toxicity based on structural analogy, at times quite minor variations may have major consequences outcomes toxicity. In this perspective, effects detailed group related hydroxy- alkoxy-substituted allyl- propenylbenzenes. These classes compounds naturally occurring constituents...
In 2015, the Expert Panel of Flavor and Extract Manufacturers Association (FEMA) initiated a re-evaluation safety over 250 natural flavor complexes (NFCs) used as flavoring ingredients. This publication is first in series summarizes evaluation 54 Citrus-derived NFCs using procedure outlined Smith et al. (2005) updated Cohen (2018) to evaluate naturally-occurring mixtures for their intended use The relies on complete chemical characterization each NFC commerce organization NFC's constituents...
This guidance document provides a tiered framework for risk assessors and facilitates managers in making decisions concerning the approval of active substances (AS) that are chemicals plant protection products (PPPs) biocidal products, authorisation products. Based on approaches presented this document, conclusion can be drawn impact water treatment processes residues AS or its metabolites surface and/or groundwater abstracted production drinking water, i.e. formation transformation (TPs)....
In 2015, the Expert Panel of Flavor and Extract Manufacturers Association (FEMA) initiated a re-evaluation safety over 250 natural flavor complexes (NFCs) used as ingredients. NFC materials include variety essential oils botanical extracts. The NFCs is conducted based on constituent-based procedure outlined in 2005 updated 2018 that evaluates for their intended use This applied generally recognized safe (GRAS) status with constituent profiles are dominated by alicyclic ketones such menthone...
The absence of a direct route to the apical plasma membrane (PM) for single transmembrane domain (TMD) proteins in polarized hepatic cells has been inferred but never directly demonstrated. genes encoding three pairs PM proteins, whose extracellular domains are targeted exclusively milieu Madin-Darby canine kidney cells, were packaged into recombinant adenovirus and delivered WIF-B vitro liver hepatocytes vivo. By immunofluorescence pulse-chase metabolic labeling, we found that soluble...
A refined exposure assessment was undertaken to calculate the estimated daily intake (EDI) of seven FD&C straight-colour additives and five colour lakes ('synthetic' food colours) approved in United States. The EDIs were calculated for US population as a whole specific age groups, including children aged 2-5 6-12 years, adolescents 13-18 adults 19 or more y. Actual use data collected from an industry survey companies that are users these variety products, with additional input manufacturers....
ABSTRACT Downstream signaling triggered by the binding of fibroblast growth factor-2 (FGF2) to its tyrosine-kinase receptors involves activation mitogen-activated protein kinase (MEK) with consequent phosphorylation extracellular signal-regulated kinases (ERKs). Here we demonstrate that FGF2 induces ERK1/2 in bovine aortic endothelial (BAE) cells and continuous presence factor is required for sustained phosphorylation. This prevented MEK inhibitors PD 098059 U0126, which also inhibit...
Two independent 90-day GLP-compliant studies were conducted in Sprague-Dawley rats with β-caryophyllene or epoxide, two common flavoring and fragrance materials. Dietary concentrations of 3500; 7000; 21,000 ppm for males 14,000; 56,000 females. epoxide 1750; 10,500; ppm. There no deaths clinical toxicity attributable to either substance administration. Statistically significant, dose-dependent reductions body weight, weight gain, food consumption, efficiency at the highest dietary...
Unlike simple epithelial cells that directly target newly synthesized glycophosphatidylinositol (GPI)-anchored and single transmembrane domain (TMD) proteins from the trans-Golgi network to apical membrane, hepatocytes use an indirect pathway: are delivered basolateral then selectively internalized transcytosed plasma membrane. Myelin lymphocyte protein (MAL) MAL2 have been identified as regulators of direct delivery, respectively. Hepatocytes lack endogenous MAL consistent with absence...
This publication is the 1st in a series of publications by Expert Panel Flavor and Extract Manufacturers Assoc. summarizing Panel's 3rd re-evaluation Generally Recognized as Safe (GRAS) status referred to GRASr2 program. In 2011, initiated comprehensive program re-evaluate safety more than 2700 flavor ingredients that have previously met criteria for GRAS under conditions intended use ingredients. Elements are fundamental evaluation include exposure, structural analogy, metabolism,...