A5102991630- Carcinogens and Genotoxicity Assessment
- Peroxisome Proliferator-Activated Receptors
- Neuroscience and Neuropharmacology Research
- Arsenic contamination and mitigation
- Pharmacogenetics and Drug Metabolism
- Animal testing and alternatives
- Genomics, phytochemicals, and oxidative stress
- Effects and risks of endocrine disrupting chemicals
- Sulfur Compounds in Biology
- Hedgehog Signaling Pathway Studies
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Bladder and Urothelial Cancer Treatments
- RNA Research and Splicing
- Potato Plant Research
- Genetics and Neurodevelopmental Disorders
- Ubiquitin and proteasome pathways
- Developmental Biology and Gene Regulation
- Epigenetics and DNA Methylation
- Biochemical Analysis and Sensing Techniques
- Heavy Metal Exposure and Toxicity
- Environmental Toxicology and Ecotoxicology
- Cancer, Lipids, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Immunotoxicology and immune responses
University of Nebraska Medical Center
2007-2025
University of Pennsylvania
2024
NYU Langone Health
2012-2023
Stanford University
2021
Harvard University
2013-2020
Dana-Farber Cancer Institute
2013-2020
Second Affiliated Hospital of Zhejiang University
2018
New York University
2014-2018
Nebraska Medical Center
1977-2014
University of British Columbia
2004
The last several years have seen considerable confusion regarding the terms "apoptosis" and "necrosis" in pathology. This situation prompted Society of Toxicologic Pathologists to charter Committee on Nomenclature Cell Death, which was charged with making recommendations about use toxicity studies. recommends term describe findings comprising dead cells histological sections, regardless pathway by died. modifiers "apoptotic" "oncotic" or "mixed apoptotic oncotic" are recommended specify...
Four trivalent arsenic species, inorganic arsenite (iAs(III)), monomethylarsonous acid (MMA(III)), dimethylarsinous (DMA(III)), and phenylarsine oxide (PhAs(III)O), have shown increasing binding affinity with the hemoglobin (Hb) of rats humans. The stoichiometry was consistent number reactive cysteine residues in alpha beta chains Hb. Comparing rat Hb human for same 3-16 times stronger than as demonstrated by their apparent constants. Comparative experiments involving incubation red blood...
The two-year rodent bioassay remains the mainstay for carcinogenicity testing, although numerous difficulties have been identified. Fundamentally, a chemical can increase risk of cancer (1) by damaging DNA directly (DNA reactive) or (2) indirectly increasing number replications (non-DNA reactive). Mechanistic research has identified precursor lesions in sequence key events necessary neoplasia development. Based on these concepts, author proposed short-term (thirteen-week) assay screening...
High doses of sodium phenobarbital (NaPB), a constitutive androstane receptor (CAR) activator, have been shown to produce hepatocellular tumors in rodents by mitogenic mode action (MOA) involving CAR activation. The effect 1-week dietary treatment with NaPB on liver weight and histopathology, hepatic CYP2B enzyme activity CYP2B/3A mRNA expression, replicative DNA synthesis selected genes related cell proliferation, functional transcriptomic metabolomic analyses was studied male CD-1 mice,...
Learning and memory depend on neuronal plasticity originating at the synapse requiring nuclear gene expression to persist. However, how synapse-to-nucleus communication supports long-term behavior has remained elusive. Among cytonuclear signaling proteins, γCaMKII stands out in its ability rapidly shuttle Ca2+/CaM nucleus thus activate CREB-dependent transcription. Here we show that elimination of prevents activity-dependent key genes (BDNF, c-Fos, Arc), inhibits persistent synaptic...
Sonic Hedgehog (Shh) signaling is crucial for growth, cell fate determination, and axonal guidance in the developing nervous system. Although receptors Patched (Ptch1) Smoothened (Smo) are required Shh signaling, a number of distinct co-receptors contribute to these critical responses Shh. Several membrane-embedded proteins such as Boc, Cdo, Gas1 bind promote signaling. In addition, heparan sulfate proteoglycans (HSPGs) have also been implicated initiation responses. However, attributes...
Chronic progressive nephropathy (CPN) is a spontaneous renal disease of rats which can be serious confounder in toxicology studies. It with known physiological factors that modify progression, such as high dietary protein. The weight evidence supports an absence counterpart humans. There extensive advanced CPN, particularly end-stage kidney, risk factor for development background incidence atypical tubule hyperplasia and tumors (RTT). likely cause underlying this association neoplasia the...
Abstract Bovine rumen fluid and slurried hamster feces completely reduced millimolar levels of arsenate to arsenite upon incubation under anoxic conditions. This activity was strongly inhibited by autoclaving or aerobic conditions, partially tungstate chloramphenicol. The rate reduction faster in from a population arsenate-watered (100 ppm) hamsters compared control group watered without arsenate. Using radioisotope methods, reductase also detected at very low concentrations added (...
The present study was conducted to determine whether long-lasting desensitization of bladder afferents could be achieved using a single local application the capsaicin (CAP)-like irritant resiniferatoxin (RTX), and compare effects RTX CAP on behavioral histological endpoints. While rats were anesthetized, vehicle (VEH), (10-100 nmol) or mumol) instilled in (intravesical, i.ves.) via cannula surgically implanted into dome. Beginning 1 week after treatment, once per for 4 weeks, tested...