A5002420632- Effects and risks of endocrine disrupting chemicals
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Health, Environment, Cognitive Aging
- Computational Drug Discovery Methods
- Pharmacogenetics and Drug Metabolism
- Pesticide Exposure and Toxicity
- Chemical Safety and Risk Management
- Air Quality and Health Impacts
- Drug-Induced Hepatotoxicity and Protection
- Toxic Organic Pollutants Impact
- Drug Transport and Resistance Mechanisms
- Climate Change and Health Impacts
- Pesticide Residue Analysis and Safety
- Agricultural safety and regulations
- Chemistry and Chemical Engineering
- Metabolomics and Mass Spectrometry Studies
- Air Quality Monitoring and Forecasting
- Environmental Justice and Health Disparities
- Per- and polyfluoroalkyl substances research
- Environmental Chemistry and Analysis
- Nanotechnology research and applications
- Free Radicals and Antioxidants
- Research Data Management Practices
- Weed Control and Herbicide Applications
Flemish Institute for Technological Research
2017-2025
Ollscoil na Gaillimhe – University of Galway
2019
Joint Research Centre
2015-2018
National Institute for Public Health and the Environment
2007-2015
Pension Fund for Care and Well-Being
2007
Netherlands Environmental Assessment Agency
2003-2005
Food & Nutrition
1998-2004
Vrije Universiteit Amsterdam
1992-2001
University of Amsterdam
1993
Graduate School Experimental Plant Sciences
1989
The European Human Biomonitoring Initiative (HBM4EU1) has established a Union-wide human biomonitoring (HBM) programme to generate knowledge on internal exposure chemical pollutants and their potential health impacts in Europe, order support policy makers' efforts ensure safety improve Europe. A prioritisation strategy was necessary determine meet the most important needs of both makers risk assessors, as well common national participating countries broad range stakeholders. This consisted...
Abstract Background Many phthalates are environmental pollutants and toxic to humans. Following phthalate regulations, human exposure has globally decreased with time in European countries, the US Korea. Conversely, their substitutes DEHT and/or DINCH increased. In other including China, little is known on time-trends these plasticizers. Objective We aimed estimate urinary concentrations of phthalates, DEHT, metabolites, general population from non-European last decade. Methods compiled...
Abstract Once an external factor has been deemed likely to influence human health and a dose response function is available, assessment of its impact or that policies aimed at influencing this possibly other factors in specific population can be obtained through quantitative risk assessment, (HIA) study. The usually expressed as number disease cases disability-adjusted life-years (DALYs) attributable expected from the exposure policy. We review methodology studies based on data. main steps...
Human health risk assessment is historically built upon animal testing, often following Organisation for Economic Co-operation and Development (OECD) test guidelines exposure assessments. Using combinations of human relevant in vitro models, chemical analysis computational (in silico) approaches bring advantages compared to studies. These include a greater focus on the species molecular mechanisms kinetics, identification Adverse Outcome Pathways downstream Key Events as well possibility...
One of the aims European Human Biomonitoring Initiative, HBM4EU, was to provide examples and good practices for effective use human biomonitoring (HBM) data in health risk assessment (RA). The need such information is pressing, as previous research has indicated that regulatory assessors generally lack knowledge experience HBM RA. By recognising this gap expertise, well added value incorporating into RA, paper support integration Based on work we different approaches including RA estimations...
Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, bioaccumulative class of chemicals, which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health environment. Within European Biomonitoring Initiative HBM4EU, samples data were collected harmonized way from biomonitoring (HBM) studies Europe derive current exposure across geographic spread. We performed mixture risk assessments based on...
Human biomonitoring (HBM) data measured in specific contexts or populations provide information for comparing population exposures. There are numerous health-based guidance values, but to locate these interested parties need seek them out individually from publications, governmental reports, websites and other sources. Until now, there has been no central, international repository this information. Thus, a tool is needed help researchers, public health professionals, risk assessors,...
The chemical burden on the environment and human population is increasing. Consequently, regulatory risk assessment must keep pace to manage, reduce, prevent adverse impacts environmental health associated with hazardous chemicals. Surveillance of chemicals known, emerging, or potential future concern, entering environment-food-human continuum needed document reality risks posed by ecosystem from a one perspective, feed into early warning systems support public policies for exposure...
Abstract Background Despite its potential with regard to the prevention and early detection of colorectal cancer (CRC), participation in organized CRC screening programme Belgian region Flanders is suboptimal. The role language discordance as a determinant Europe poorly understood, despite being identified barrier qualitative non-European studies. Methods In an ecological study analysing data on level Flemish municipalities ( n = 300) from 2016 2021, we investigated whether proportion...
Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly concentrations urine below or around detection limit (0.1 µg/L). The 95th percentiles ranged between 0.18 and 1.03 µg Gly/L. ratio AMPA (aminomethylphosphonic acid; main metabolite Gly) molar basis was average 2.2...