A5049117734- Toxic Organic Pollutants Impact
- Effects and risks of endocrine disrupting chemicals
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Animal testing and alternatives
- Air Quality and Health Impacts
- Contact Dermatitis and Allergies
- Smoking Behavior and Cessation
- Tattoo and Body Piercing Complications
- Atmospheric chemistry and aerosols
- Dermatologic Treatments and Research
- Health, Environment, Cognitive Aging
- Scientific Measurement and Uncertainty Evaluation
- Occupational exposure and asthma
- Consumer Attitudes and Food Labeling
- Chemical Safety and Risk Management
- Pesticide Exposure and Toxicity
- Biochemical Analysis and Sensing Techniques
- Nuclear and radioactivity studies
- Dermatology and Skin Diseases
- Sustainable Development and Environmental Management
- Pharmaceutical and Antibiotic Environmental Impacts
- Food Waste Reduction and Sustainability
- Skin Protection and Aging
- Immunotoxicology and immune responses
National Institute for Public Health and the Environment
2020-2024
Amsterdam UMC Location Vrije Universiteit Amsterdam
2018
Amsterdam University Medical Centers
2018
Utrecht University
2017
Per- and polyfluoroalkyl substances (PFAS) often occur together as contamination in exposure media such drinking water or food. The relative potency factor (RPF) methodology facilitates the risk assessment of mixture exposure. A database liver endpoints was established for 16 PFAS, using data with same species (rat), sex (male), route (oral) comparable duration (42-90 d). Dose-response analysis applied to derive potencies 3 perfluoroalkyl sulfonic acids (perfluorobutane acid, perfluorohexane...
Relative potency factors (RPFs) for per- and polyfluoroalkyl substances (PFAS) have previously been derived based on liver effects in rodents the purpose of performing mixture risk assessment with primary input from biomonitoring studies. However, 2020, EFSA established a tolerable weekly intake four PFAS assuming equal toxic immune suppressive humans. In this study we explored possibility deriving RPFs using available data Lymphoid organ weights, differential blood cell counts, clinical...
One of the aims European Human Biomonitoring Initiative, HBM4EU, was to provide examples and good practices for effective use human biomonitoring (HBM) data in health risk assessment (RA). The need such information is pressing, as previous research has indicated that regulatory assessors generally lack knowledge experience HBM RA. By recognising this gap expertise, well added value incorporating into RA, paper support integration Based on work we different approaches including RA estimations...
Per- and polyfluoroalkyl substances (PFASs) are a highly persistent, mobile, bioaccumulative class of chemicals, which emissions into the environment result in long-lasting contamination with high probability for causing adverse effects to human health environment. Within European Biomonitoring Initiative HBM4EU, samples data were collected harmonized way from biomonitoring (HBM) studies Europe derive current exposure across geographic spread. We performed mixture risk assessments based on...
Background: In human biomonitoring, blood is often used as a matrix to measure exposure per- and polyfluoroalkyl substances (PFAS). Because the toxicokinetics of substance (determining steady-state concentration) may affect toxic potency, difference in among PFAS has be accounted for when concentrations are mixture risk assessment. Objectives: This research focuses on deriving relative potency factors (RPFs) at serum level. These RPFs can applied blood, thereby facilitating assessment with...
Comparing the harmful health effects related to two different tobacco products by applying common risk assessment methods each individual compound is problematic. We developed a method that circumvents some of these problems focusing on change in cumulative exposure (CCE) compounds emitted considered. The consists six steps. first three steps encompass dose-response analysis cancer data, resulting relative potency factors with confidence intervals. fourth step evaluates emission intervals...
During the last decade, number of people with ≥1 tattoo has increased noticeably within European population. Despite this, limited safety information is available for inks.To test skin sensitization potential 5 inks in vitro by using reconstructed human (RHS) and contact biomarker interleukin (IL)-18.Two red 3 black inks, 1 additive (Hamamelis virginiana extract) irritant control (lactic acid) were tested. The culture medium RHS (reconstructed epidermis on a fibroblast-populated collagen...
Voedselcontactmaterialen zijn verpakkingsmaterialen voor levensmiddelen en gebruiksartikelen zoals pannen, servies bakvormen. PFAS'en worden in deze materialen gebruikt omdat ze vet afstoten. Het blijkt dat sommige die papier karton zitten, voedsel terecht kunnen komen. Hier zitten ook stoffen bij niet het voedselcontactmateriaal mogen gebruikt. Op dit moment is er onvoldoende informatie beschikbaar om van een betrouwbare blootstellingsschatting risicobeoordeling te maken. Dit uit onderzoek...
Safety assessment of UV filters for human health by the Scientific Committee on Consumer (SCCS) is based estimation internal dose following external (skin) application cosmetic products, and comparison with a toxicological reference value after conversion to dose. Data from biomonitoring (HBM) could be very useful in this regard, because it measurement real-life exposure population chemical. were included priority list compounds addressed under European Human Biomonitoring Initiative...
Many novel tobacco products have been developed in recent years. Although many may emit lower levels of several toxicants, their risk the long term remains unclear. We previously published a method for exposure assessment mixtures that can be used to compare changes cumulative carcinogens among products. While further developing this by including more or explore its application non-cancer endpoints, we encountered lack data are required better-substantiated conclusions regarding differences...