A5060524945- Effects and risks of endocrine disrupting chemicals
- Mercury impact and mitigation studies
- Heavy Metal Exposure and Toxicity
- Toxic Organic Pollutants Impact
- Pharmaceutical studies and practices
- Heavy metals in environment
- Carcinogens and Genotoxicity Assessment
- Per- and polyfluoroalkyl substances research
- Pharmaceutical and Antibiotic Environmental Impacts
- Aquatic Ecosystems and Phytoplankton Dynamics
- Marine and coastal ecosystems
- Environmental Toxicology and Ecotoxicology
- Heavy Metals in Plants
- Animal testing and alternatives
- Primary Care and Health Outcomes
- Health, Environment, Cognitive Aging
- Diet and metabolism studies
- Health Promotion and Cardiovascular Prevention
- Vitamin D Research Studies
- Biopolymer Synthesis and Applications
- Health and Medical Studies
- Meat and Animal Product Quality
- Trace Elements in Health
- Wildlife Ecology and Conservation
- Isotope Analysis in Ecology
German Environment Agency
2021-2024
Federal Institute for Risk Assessment
2015-2018
Leibniz Institute for Baltic Sea Research
2004-2005
One of the aims European Human Biomonitoring Initiative, HBM4EU, was to provide examples and good practices for effective use human biomonitoring (HBM) data in health risk assessment (RA). The need such information is pressing, as previous research has indicated that regulatory assessors generally lack knowledge experience HBM RA. By recognising this gap expertise, well added value incorporating into RA, paper support integration Based on work we different approaches including RA estimations...
Phthalates and the substitute plasticizer DINCH belong to first group of priority substances investigated by European Human Biomonitoring Initiative (HBM4EU) answer policy-relevant questions safeguard an efficient science-to-policy transfer results. internal exposure levels were assessed using two data sets from all regions Israel. The collated existing human biomonitoring (HBM) (2005-2019). second consisted new generated in harmonized "HBM4EU Aligned Studies" (2014-2021) on children...
The toxicity of lead has been known for a long time, and no safe uptake level can be derived humans. Consumers' intake via food should therefore kept as low possible. Game meat contain elevated levels due to the use ammunition hunting. A risk assessment conducted in 2010 by German Federal Institute Risk Assessment including various consumption scenarios revealed possible health extreme consumers game hunted with (i.e. hunters members hunters' households). Babies, infants, children women...
The uptake of polychlorinated biphenyls (PCBs) was studied in four species marine algae. A novel experimental system to establish and maintain constant dissolved concentrations PCBs employed. Headspace sampling used verify that the freely remained with time. headspace analysis also allowed sorption organic carbon (DOC) be quantified for all but most lipophilic PCB congeners. Equilibration phase rapid three algae (<1 d majority congeners). Organic carbon-normalized algae/water partition...
The aim of this study was to examine the contamination game meat with copper and zinc establish whether use alternative (non-lead) ammunition can lead higher or unsafe levels in roe deer, wild boar red deer. research project "Safety obtained through hunting" (LEMISI) conducted Germany purpose examining entry as well into hunted when using either non-lead ammunition. outcome shows that usage both lead-based results edible parts game. Using does not entail dangerously elevated zinc, so...
Game meat may contain elevated concentrations of lead especially if lead-containing ammunition is used for hunting. Then a health risk possible consumer groups with high game intake. The in three edible parts (marketable from the area close to wound channel, saddle and haunch) red deer (Cervus elaphus) between animals hunted either or non‑lead were compared. Furthermore, levels lead-shot compared those roe wild boar. Ninety shot killed context this study (64 26 ammunition). Since...
Toxicologically and/or epidemiologically derived guidance values referring to the internal exposure of humans are a prerequisite for an easy use health-based interpretation human biomonitoring (HBM) results. The European Joint Programme HBM4EU derives such values, named (HBM-GVs), priority substances which could be regulatory relevance policy makers and have been identified by experts participating countries, ministries, agencies stakeholders at EU national level. NMP NEP unresolved relevant...
Phthalates are mainly used as plasticizers and associated inter alia with adverse effects on reproductive functions. While more national programs in Europe have started monitoring internal exposure to phthalates its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across is challenging. They differ widely time periods, study samples, degree geographical coverage, design, analytical methodology, biomarker...
Phthalates are ubiquitous in the environment. Despite short half-lives, chronic exposure can lead to endocrine disruption. The safety of phthalate substitute DINCH is unclear. To evaluate associations between urinary concentrations phthalate/DINCH metabolites and body mass index (BMI) z-score among children adolescents. We used Human Biomonitoring for Europe Aligned Studies data from 2876 (12 studies, 6–12 years, 2014–2021) 2499 adolescents (10 12–18 with up 14 metabolites. multilevel linear...
Early puberty has been found to be associated with adverse health outcomes such as metabolic and cardiovascular diseases hormone-dependent cancers. The decrease in age at menarche observed during the past decades linked an increased exposure endocrine-disrupting compounds (EDCs). Evidence for association between PFAS phthalate onset, however, is inconsistent. We studied phthalate/DINCH using data of 514 teenagers (12 18 years) from four aligned studies Human Biomonitoring Europe initiative...