Laura Rodríguez Martin
A5005744254- Effects and risks of endocrine disrupting chemicals
- Toxic Organic Pollutants Impact
- Air Quality and Health Impacts
- Potato Plant Research
- Per- and polyfluoroalkyl substances research
- Carcinogens and Genotoxicity Assessment
- Health, Environment, Cognitive Aging
- Heavy Metal Exposure and Toxicity
- Mercury impact and mitigation studies
- Birth, Development, and Health
- Environmental Justice and Health Disparities
- Pesticide Residue Analysis and Safety
- Liver Disease Diagnosis and Treatment
- Liver Diseases and Immunity
- Computational Drug Discovery Methods
- Heavy metals in environment
- Immunotoxicology and immune responses
- Stress Responses and Cortisol
- Software Reliability and Analysis Research
- Pancreatitis Pathology and Treatment
- Celiac Disease Research and Management
- Network Security and Intrusion Detection
- Microplastics and Plastic Pollution
- Biliary and Gastrointestinal Fistulas
- Noise Effects and Management
Flemish Institute for Technological Research
2020-2025
Complejo Asistencial Universitario de Palencia
2023-2025
Ministry of Health
2022
Airbus (France)
2015
As part of the Human Biomonitoring for Europe (HBM4EU) initiative a human biomonitoring (HBM) survey is conducted in 21 countries. This builds on existing HBM capacity by aligning national or regional studies. The targets 3 age groups (i) children aged 6-11 years, (ii) teenagers 12-19 years and (iii) young adults 20-39 includes total 9493 participants (3151 children, 2953 3389 adults). Depending group, internal exposure to phthalates substitute Hexamoll® DINCH, brominated organophosphorus...
Human biomonitoring has become a pivotal tool for supporting chemicals’ policies. It provides information on real-life human exposures and is increasingly used to prioritize chemicals of health concern evaluate the success chemical Europe launched ambitious REACH program in 2007 improve protection environment. In October 2020 EU commission published its new strategy sustainability towards toxic-free The European Parliament called upon collect data support chemical’s risk assessment...
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL;...
Autoimmune hepatitis (AIH) is an immune-mediated disease characterised by elevated transaminases, immunoglobulin G and autoantibody positivity. Treatment based on corticosteroids azathioprine. Up to 15% of patients will require a second line treatment, with remission rates after this about 60-75%. There controversy what the next step treatment should be. We present case woman diagnosed IAH who failed several lines had start infliximab despite off-label indication, but favorable clinical response.
Phthalates and the substitute plasticizer DINCH belong to first group of priority substances investigated by European Human Biomonitoring Initiative (HBM4EU) answer policy-relevant questions safeguard an efficient science-to-policy transfer results. internal exposure levels were assessed using two data sets from all regions Israel. The collated existing human biomonitoring (HBM) (2005-2019). second consisted new generated in harmonized "HBM4EU Aligned Studies" (2014-2021) on children...
The Flemish Environment and Health Study (FLEHS) collects information on internal exposure to a broad range of environmental chemicals in the general population Flanders, Northern region Belgium. aim is establish biomonitoring distributions for support public health policy, risk assessment management decisions. In 2017-2018, urine blood samples were collected from 428 teenagers by stratified clustered two stage randomized design. Samples analyzed biomarkers related chlorinated newer...
Exposure to environmental pollutants can disrupt normal immune system development and functioning, which may lead long-term health consequences. However, the impact of exposure chemical mixtures on adolescent has not been extensively studied. White blood cells (leukocytes) are part system, an elevated leukocyte count is considered a biomarker inflammation in clinical settings. The present study examined associations 14 biomarkers measured with counts total leukocytes subtypes 980 adolescents...
Human biomonitoring (HBM) data in Europe are often fragmented and collected different EU countries sampling periods. Exposure levels for children adult women were evaluated over time. For the period 2000–2010, literature aggregated a harmonized way across studies. Between 2011–2012, biobanked samples from DEMOCOPHES project used. 2014–2021, HBM generated within HBM4EU Aligned Studies. Time patterns on internal exposure visually statistically using 50th 90th percentiles (P50/P90)...
Due to their extensive usage, organophosphorus flame retardants (OPFRs) have been detected in humans and the environment. Human are exposed OPFRs via inhalation of indoor air, dust uptake or dietary through contaminated food drinking water. Only recently, few studies addressing exposure were published. In this study, we used human biomonitoring (HBM) data estimate how much intake may contribute total exposure. We estimated by reverse dosimetry, daily tris (2-chloroethyl) phosphate (TCEP),...
More than 20 years ago, acrylamide was added to the list of potential carcinogens found in many common dietary products and tobacco smoke. Consequently, human biomonitoring studies investigating exposure form adducts blood metabolites urine have been performed obtain data on actual burden different populations world Europe. Recognizing related health risk, European Commission responded with measures curb content food products. In 2017, a trans-European project (HBM4EU) started aim...
Exposure to air pollution and traffic noise are associated with adverse health outcomes in adolescents. Chronic endocrine stress systemic inflammation have been hypothesized underlie the effects. Simultaneous assessment of chronic epidemiological studies is lacking. The aim study was investigate biomarkers relation long-term residential exposure In Flemish adolescents (14–15 years), we determined hair cortisol concentration (HCC) as a biomarker 3-cm scalp-near sections (n = 395), leucocyte...
Polycyclic aromatic hydrocarbons (PAHs) are environmental pollutants of public health concern. Multiple biological mechanisms have been hypothesized to contribute PAHs-associated adverse effects. Little is known about the impact PAHs on endocrine stress and inflammation in adolescence. We examined 393 Flemish adolescents (14-15 years) cross-sectionally, measured urinary concentrations hydroxylated naphthalene, fluorene, phenanthrene pyrene metabolites, calculated sum all metabolites....
Children are born with a burden of persistent organic pollutants (POPs) which may have endocrine disrupting properties and been postulated to contribute the rise in childhood obesity. The current evidence is equivocal, partly because many studies investigate effects at one time point during childhood. We assessed associations between prenatal exposure POPs growth infancy childhood.We used data from two Belgian cohorts cord blood measurements five organochlorines...
Human health risk assessment of chemical mixtures is complex due to the almost infinite number possible combinations chemicals which people are exposed on a daily basis. biomonitoring (HBM) approaches can provide inter alia information that in our body at one point time. Network analysis applied such data may insight into real-life by visualizing exposure patterns. The identification groups more densely correlated biomarkers, so-called “communities”, within these networks highlights...
Phthalates are mainly used as plasticizers and associated inter alia with adverse effects on reproductive functions. While more national programs in Europe have started monitoring internal exposure to phthalates its substitute 1,2-Cyclohexanedicarboxylic acid (DINCH), the comparability of results from such existing human biomonitoring (HBM) studies across is challenging. They differ widely time periods, study samples, degree geographical coverage, design, analytical methodology, biomarker...
Abstract Little is known about exposure determinants of acrylamide (AA), a genotoxic food-processing contaminant, in Europe. We assessed AA exposure, measured by urinary mercapturic acids (AAMA) and glycidamide (GAMA), its main metabolite, 3157 children/adolescents 1297 adults the European Human Biomonitoring Initiative. Harmonized individual-level questionnaires data quality assured measurements AAMA GAMA (urine collection: 2014–2021), short-term validated biomarkers were obtained from four...
Information about the effects of phthalates and non-phthalate substitute cyclohexane-1,2-dicarboxylic acid diisononyl ester (HEXAMOLL® DINCH) on children's neurodevelopment is limited. The aim present research to evaluate association between phthalate/HEXAMOLL® DINCH exposure child in three European cohorts involved HBM4EU Aligned Studies. Participating subjects were school-aged children belonging Northern Adriatic cohort II (NAC-II), Italy, Odense Child Cohort (OCC), Denmark, PCB cohort,...
This paper presents a model to evaluate and select security countermeasures from pool of candidates. The performs industrial evaluation simulations the financial technical impact associated countermeasures. approach uses Return On Response Investment (RORI) index compare expected attack when no response is enacted against after applying evaluates protection level threat, in terms confidentiality, integrity, availability. We provide use case on malware attacks that shows applicability our...
Acrylamide, a substance potentially carcinogenic in humans, represents very prevalent contaminant food and is also contained tobacco smoke. Occupational exposure to higher concentrations of acrylamide was shown induce neurotoxicity humans. To minimize related risks for public health, it vital obtain data on the actual level differently affected segments population. achieve this aim, has been added list substances concern be investigated HBM4EU project, European initiative biomonitoring...