A5012195755- Air Quality and Health Impacts
- Effects and risks of endocrine disrupting chemicals
- Health, Environment, Cognitive Aging
- Toxic Organic Pollutants Impact
- Pesticide Exposure and Toxicity
- Carcinogens and Genotoxicity Assessment
- Heavy Metal Exposure and Toxicity
- RNA and protein synthesis mechanisms
- Birth, Development, and Health
- Energy and Environment Impacts
- RNA Research and Splicing
- SARS-CoV-2 and COVID-19 Research
- Climate Change and Health Impacts
- Human Health and Disease
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Per- and polyfluoroalkyl substances research
- Maternal Mental Health During Pregnancy and Postpartum
- Cellular transport and secretion
- Ubiquitin and proteasome pathways
- Health, Medicine and Society
- Child Nutrition and Water Access
- Adolescent and Pediatric Healthcare
- SARS-CoV-2 detection and testing
- Genomics and Chromatin Dynamics
- Long-Term Effects of COVID-19
Inserm
2016-2025
Institut national d'études démographiques
2013-2025
Campus Condorcet
2019-2024
Etude longitudinale française depuis l'enfance
2018-2021
Institut National de Santé Publique
2021
Santé Publique France
2021
Assistance Publique – Hôpitaux de Paris
2007-2010
Sorbonne Université
2010
Pitié-Salpêtrière Hospital
2010
Laboratoire de Biologie Moléculaire et Cellulaire des Eucaryotes
2009
After an infection by SARS-CoV-2, many patients present with persistent physical symptoms that may impair their quality of life. Beliefs regarding the causes these influence perception and promote maladaptive health behaviors.
ELFE is the first French national birth cohort. Its objective to study determinants of development, health and socialization children from adulthood through a multidisciplinary approach. A total 18 329 were recruited at in random sample maternity units metropolitan France during 25 selected days 2011 spread over year. Follow-up 5 years consisted telephone interviews both parents child age 2 months 1 year years, one parent 3.5 years; home visit questionnaires child’s physician nursery school...
Transthyretin familial amyloid polyneuropathies (TTR-FAPs) are autosomal dominant neuropathies of fatal outcome within 10 years after inaugural symptoms. Late diagnosis in patients who present as nonfamilial cases delays adequate management and genetic counseling. Clinical data the 90 presented 300 our cohort with TTR-FAP were reviewed. They 21 women 69 men a mean age at onset 61 (extremes: 38 to 78 years) 17 different mutations TTR gene including Val30Met (38 cases), Ser77Tyr (16 Ile107Val...
The quantitative assessment of human exposure to contaminants such as pesticides is a crucial step in the characterization exposure-associated risk. For this purpose, biomonitoring often privileged it presents advantage integrating all possible sources and routes being representative internal dose resulting from exposure. Although biological fluids urine blood have been used date for increasing interest has also observed over past decade hair analysis. present work aimed at comparing...
Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL;...
Spinocerebellar ataxia type 28 is an autosomal dominant form of cerebellar (ADCA) caused by mutations in AFG3L2, a gene that encodes subunit the mitochondrial m-AAA protease. We screened 366 primarily Caucasian ADCA families, negative for most common triplet expansions, point AFG3L2 using DHPLC. Whole-gene deletions were excluded 300 patients, and duplications 129 patients. found six missense nine unrelated index cases (9/366, 2.6%): c.1961C>T (p.Thr654Ile) exon 15, c.1996A>G (p.Met666Val),...
Nutritional factors are essential for the functioning of immune system and could therefore play a role in COVID-19 but evidence is needed. Our objective was to study associations between diet risk SARS-CoV-2 infection large population-based sample.Our analyses were conducted French prospective NutriNet-Santé cohort (2009-2020). Seroprevalence anti-SARS-CoV-2 antibodies assessed by ELISA on dried blood spots. Dietary intakes derived from repeated 24 h dietary records (at least 6) two years...
Transthyretin (TTR) familial amyloid polyneuropathy is a severe autosomal dominant neuropathy of adulthood, frequently linked to the pathogenic Val30Met variant TTR gene. The condition was initially described in northern Portugal, which first focus disease. Other important clusters families are found Sweden, Japan and South America. origin mutation its distribution through populations remains unclear. In present work, we aimed at refining history patients affected with from Sweden Brazil....
Familial amyloid polyneuropathy (FAP) type I is a severe autosomal dominant inherited neuropathy associated with mutations in the transthyretin (TTR) gene. Significant phenotypic variability seen amongst families distinct geographic origin, especially regarding penetrance and age of onset. The aim this study was to estimate FAP Brazilian families.Twenty-two were ascertained through genetically confirmed index cases included study. Genealogical clinical data obtained from total 623...
Early life gut microbiota-influencing factors may play an important role in programming individuals long-term health and substantial efforts have been devoted into studying the development of microbiota relation to early events. This study aimed examine a single study, persistence associations between 20 occurring at 3.5 years 798 children from two French nationwide birth cohorts, EPIPAGE 2 (very preterm children) ELFE (late full-term children). Gut profiling was assessed using 16S rRNA gene...
Pyrethroids are widely used pesticides and suspected to affect children's neurodevelopment. The characterization of pyrethroid exposure during critical windows development, such as fetal development prenatal life, is essential ensure a better understanding pyrethroids potential effects within the concept Developmental Origins Health Disease. aim this study was estimate maternal French pregnant women from biomonitoring data simulate internal concentrations 3 (permethrin, cypermethrin...
The essential C17 subunit of yeast RNA polymerase (Pol) III interacts with Brf1, a component TFIIIB, suggesting role for in the initiation step transcription. protein sequence (encoded by RPC17) is conserved from yeasts to humans. However, mammalian homologues (named CGRP-RCP) are known be involved signal transduction pathway related G protein-coupled receptors, not In present work, we first establish that human CGRP-RCP genuine orthologue C17. was found functionally replace Deltarpc17...
Abstract ABO blood type has been reported as a potential factor influencing SARS-CoV-2 infection, but so far mostly in studies that involved small samples, selected population and/or used PCR test results. In contrast our study aimed to assess the association between types and infection using seroprevalence data (independent of whether or not individuals had symptoms sought for testing) large population-based sample. Our included 67,340 French participants SAPRIS-SERO multi-cohort project....
The individual results of SARS-CoV-2 serological tests measured after the first pandemic wave 2020 cannot be directly interpreted as a probability having been infected. Plus, these are usually returned binary or ternary variable, relying on predefined cut-offs. We propose Bayesian mixture model to estimate infection probabilities, based 81,797 continuous anti-spike IgG from Euroimmun collected in France wave. This approach used and was therefore not diagnostic Cumulative incidence, which is...
Bisphenol A (BPA; or 4,4'-isopropylidenediphenol) is an endocrine disrupting chemical. It was widely used in a variety of plastic-based manufactured products for several years. The European Food Safety Authority (EFSA) recently reduced the Tolerable Daily Intake (TDI) BPA by 20,000 times due to concerns about immune-toxicity.
Objectives Prenatal occupational exposure to pesticides has been associated with male reproductive tract abnormalities. Little is known about the possible impact of non-occupational pesticide on fetal and child development in general population. Using data from a nationwide birth cohort, we aimed assess association between residential sources prenatal risks hypospadias cryptorchidism. Methods Of 9281 boys ELFE (French Longitudinal Study Children), national French 53 were diagnosed 137 We...
Exposure to atmospheric pollutants is a danger for the health of pregnant mother and children. Our objective was identify individual (socioeconomic behavioural) contextual factors associated with pollution pregnancy exposure at nationwide level.Among 14 921 women from French ELFE (French Longitudinal Study Children) mother-child cohort recruited in 2011, outdoor levels PM2.5, PM10 (particulate matter <2.5 µm <10 diameter) NO2 (nitrogen dioxide) were estimated home address dispersion model 1...