A5052944172- Pesticide Exposure and Toxicity
- Effects and risks of endocrine disrupting chemicals
- Maternal and Perinatal Health Interventions
- Carcinogens and Genotoxicity Assessment
- Birth, Development, and Health
- Air Quality and Health Impacts
- Health, Environment, Cognitive Aging
- Testicular diseases and treatments
- Sperm and Testicular Function
- Maternal and fetal healthcare
- Health, Medicine and Society
- Maternal Mental Health During Pregnancy and Postpartum
- Toxic Organic Pollutants Impact
- Assisted Reproductive Technology and Twin Pregnancy
- Prenatal Substance Exposure Effects
- Renal and related cancers
- Pregnancy and preeclampsia studies
- Pesticide and Herbicide Environmental Studies
- Autism Spectrum Disorder Research
- Child Nutrition and Feeding Issues
- Insect and Pesticide Research
- Academic integrity and plagiarism
- Neuroscience of respiration and sleep
- Child Welfare and Adoption
- Neonatal and fetal brain pathology
Institut de Recherche en Santé, Environnement et Travail
2016-2025
Centre Hospitalier Universitaire de Rennes
2018-2025
Inserm
2016-2024
Université de Rennes
2017-2024
École des Hautes Études en Santé Publique
2016-2024
Hôpital Pontchaillou
2020
Centre Léon Bérard
2013-2019
Université Claude Bernard Lyon 1
2013-2019
Centre International de Recherche sur le Cancer
2013-2019
Université Lumière Lyon 2
2014
There are concerns that developmental exposure to endocrine disrupting chemicals such as phenolic compounds and phthalates could affect child cognitive function. Epidemiological studies tackling this question have mainly focused on phthalate metabolites bisphenol A, but not the other compounds. Our study aimed assess relationship between in-utero phthalates, A (parabens, triclosan, dichlorophenols benzophenone-3) Intelligence Quotient (IQ) of boys at 5-6 years.In 452 mother-son dyads from...
The largest case-control study (Interphone study) investigating glioma risk related to mobile phone use showed a J-shaped relationship with reduced relative risks for moderate and 40% increased among the 10% heaviest regular users, using categorical model based on deciles of lifetime duration ever users. We conducted Monte Carlo simulations examining whether reported estimates are compatible an assumption no effect when various forms biases present in Interphone accounted for. Four scenarios...
Background:Glycol ethers (GE) are widely used organic solvents. Despite the potential neurotoxicity of several families solvents, little is known about impact GE on neurodevelopment infants and children.Objectives:We investigated relation between urinary concentrations metabolites in pregnant women neurocognitive abilities their 6-year-old children PELAGIE mother–child cohort.Methods:Five were measured first morning void urine samples 204 French early pregnancy (< 19 weeks gestation)....
At the same time that toxicologists express increasing concern about reproducibility in this field, development of dedicated databases has already smoothed path toward improving storage and exchange raw toxicogenomic data. Nevertheless, none provides access to analyzed interpreted data as originally reported scientific publications. Given demand for information, we developed TOXsIgN, a repository TOXicogenomic sIgNatures.The TOXsIgN flexible environment facilitates online submission,...
Background Testicular germ cell tumors (TGCT) are the most frequent cancer in young men developed countries. Parental occupational exposures during early-life periods suspected to increase TGCT risk. The objective was estimate association between parental occupations at birth and adult TGCT. Methods A case–control study conducted, including 454 cases aged 18–45 from 20 French university hospitals, matched 670 controls based on region year of birth. Data collected participants included jobs...
Objectives Prenatal occupational exposure to pesticides has been associated with male reproductive tract abnormalities. Little is known about the possible impact of non-occupational pesticide on fetal and child development in general population. Using data from a nationwide birth cohort, we aimed assess association between residential sources prenatal risks hypospadias cryptorchidism. Methods Of 9281 boys ELFE (French Longitudinal Study Children), national French 53 were diagnosed 137 We...
<h3>Objectives</h3> A potential impact of exposure to endocrine disruptors, including pesticides, during intrauterine life, has been hypothesised in testicular germ cell tumour (TGCT) aetiology, but assessment is challenging. This large-scale registry-based case–control study aimed investigate the association between parental occupational pesticides and TGCT risk their sons. <h3>Methods</h3> Cases born 1960 or onwards, aged 14 49 years, diagnosed 1978 2013 Denmark, Finland, Norway Sweden,...
Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men developed countries and their incidence rate has doubled worldwide over past 40 years. Early life exposures to pesticides suspected increase TGCT risk. Our research aimed at estimating adult risk associated with parental domestic use of during early periods child development. Methods We conducted a case-control study 304 cases, aged 18–45 years old, recruited 20 French university hospitals, 274...
Abstract These clinical practice guidelines from the French National College of Midwives (CNSF) are intended to define messages and preventive interventions be provided women co‐parents by different professionals providing care or their children during perinatal period. divided into 10 sections, corresponding 4 themes: 1/ adaptation maternal behaviors (physical activity, psychoactive agents); 2/ dietary behaviors; 3/ household exposure toxic substances (household uses, cosmetics); 4/...
The incidence of testicular germ cell tumors (TGCT), the most common cancer in men aged 15 to 45 years, has doubled over last 30 years developed countries. Reasons remain unclear but a role environmental factors, especially during critical periods development, is strongly suspected. Reliable data on exposure this time period are sparse. Little known whether it could be combined effect early and later-life exposures. Our research aims study association between TGCT risk pesticide exposures...
Abstract Background Maternal blood pressure levels reflect cardiovascular adaptation to pregnancy and proper maternal-fetal exchanges through the placenta are very sensitive numerous environmental stressors. hypertension during has been associated with impaired placental functions an increased risk for children suffer from respiratory diseases later on. Investigating changes in DNA methylation cell-type composition association maternal could help elucidate its relationships fetal...
Organic solvents are used in formulating an extensive range of products for professional use. Animal and human studies suggest that utero solvent exposure may affect neurodevelopment. Our objective was to assess the association between occupational during pregnancy child behavior aged 2-12 years.