A5019443101- Breastfeeding Practices and Influences
- Infant Nutrition and Health
- Child Nutrition and Feeding Issues
- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Child Nutrition and Water Access
- Neonatal Respiratory Health Research
- Child and Adolescent Health
- Viral gastroenteritis research and epidemiology
- COVID-19 Impact on Reproduction
- Pregnancy and Medication Impact
- Health, Medicine and Society
- Prenatal Screening and Diagnostics
- Clinical Nutrition and Gastroenterology
- Neuroscience of respiration and sleep
- Pediatric health and respiratory diseases
- Maternal Mental Health During Pregnancy and Postpartum
- Neonatal Health and Biochemistry
- Reproductive System and Pregnancy
- Congenital Diaphragmatic Hernia Studies
- Gestational Diabetes Research and Management
- Fatty Acid Research and Health
- Air Quality and Health Impacts
- Respiratory viral infections research
- Infant Development and Preterm Care
Assistance Publique – Hôpitaux de Paris
2014-2024
Hôpital Necker-Enfants Malades
2015-2024
Institut Necker Enfants Malades
2017-2023
Banque de France
2008-2020
Institut Technique de l'Aviculture
2007-2017
Inserm
1999-2015
Institut Cochin
2007-2015
Université Paris Cité
1999-2013
Centre National de la Recherche Scientifique
2006-2013
Génétique Animale et Biologie Intégrative
2013
Preeclampsia (PE) is a common human-specific pregnancy disorder defined by hypertension and proteinuria during gestation responsible for maternal fetal morbimortality. STOX1 , encoding transcription factor, was the first gene associated with PE as identified positional cloning approaches. Its overexpression in choriocarcinoma cells mimics transcriptional consequences of human placenta. Here, we created transgenic mouse strains overexpressing . Wild-type female mice crossed male reproduce...
Preeclampsia is the major pregnancy-induced hypertensive disorder. It modifies expression profile of placental genes, including several serine protease inhibitors ( SERPINs ). The objective this study was to perform a systematic analysis these genes in normal and pathological placentas pinpoint epigenetic alterations inside their promoter regions. Expression 18 analyzed by quantitative RT-PCR on from pregnancies complicated preeclampsia, intrauterine growth restriction, or both compared with...
ABCA3 (ATP-binding cassette subfamily A, member 3) is expressed in the lamellar bodies of alveolar type II cells and crucial to pulmonary surfactant storage homeostasis. gene mutations have been associated with neonatal respiratory distress (NRD) pediatric interstitial lung disease (ILD). The objective this study was look for patients severe NRD and/or ILD. 30 coding exons were screened 47 identified 10 out patients, including 2 homozygous, 5 compound heterozygous 3 patients. SP-B SP-C...
The distributions of the mRNAs for estrogen receptors (ERα and ERβ) their binding properties in myometria pregnant nonpregnant women leiomyoma were studied. RT-PCR analysis indicated that term pregnancy had little ERα mRNA, whereas amounts ERβ or appeared to be similar. Both mRNA greater certain than normal myometria. kinetics revealed two specific sites (with high low affinity) 17β-estradiol present myometrium. Only low-affinity detectable late-pregnancy leiomyoma, capacities increased two-...
Mutations in STOX1 were proposed to be causal for predisposing preeclampsia, a hypertensive disorder originating from placental defects, affecting up 10% of human pregnancies. However, after the first study published 2005 three other groups have dismissed polymorphism described paper as mutation.In present study, we produced choriocarcinoma cell line overexpressing STOX1. This overexpression results transcriptional modification 12.5% genes, some them being direct targets shown by chromatin...
<h3>Importance</h3> Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears promote intestinal maturation. The concentration in human milk declines rapidly post partum and absent formula; therefore, recombinant (rh) for enteral administration as supplement formula may reduce feeding infants. <h3>Objective</h3> To assess efficacy safety 2 different dosages rh both formula. <h3>Design, Setting, Participants</h3>...
Cannabis is a drug derived from hemp plant, sativa , used both as recreational or medicine. It widespread illegal substance, generally smoked for its hallucinogenic properties. Little known about the adverse effects of postnatal cannabis exposure throw breastfeeding because lack studies in lactating women. The active substance delta 9 TetraHydroCannabinol (THC). Some conclude that it could decrease motor development child at one year age. Therefore, use and abuse other drugs like alcohol,...
Background: Long-chain polyunsaturated fatty acids (LC-PUFAs) are important for newborn neurosensory development. Supplementation of breastfeeding mothers’ diets with omega-3 PUFAs, such as alpha-linolenic acid (ALA), may increase their concentration in human milk. Research aim: This study aimed to assess milk composition after 15-day supplementation regimens containing either PUFAs or olive oil, which does not provide ALA. Methods: A multicenter factorial randomized trial was conducted four...
Abstract These clinical practice guidelines from the French National College of Midwives (CNSF) are intended to define messages and preventive interventions be provided women co‐parents by different professionals providing care or their children during perinatal period. divided into 10 sections, corresponding 4 themes: 1/ adaptation maternal behaviors (physical activity, psychoactive agents); 2/ dietary behaviors; 3/ household exposure toxic substances (household uses, cosmetics); 4/...
Abstract Background As a first step to explore the possible relationships existing between effects of low oxygen pressure in trimester placenta and placental pathologies developing from mid-gestation, two subtracted libraries totaling 2304 cDNA clones were constructed. For achieving this, reciprocal suppressive/subtractive hybridization procedures (SSH) applied early (11 weeks) human villi after incubation either normoxic or hypoxic conditions. The both (1440 hypoxia-specific 864...
Intra-uterine growth restriction (IUGR) is a frequent disease, affecting up to 10% of human pregnancies and responsible for increased perinatal morbidity mortality. Moreover, low birth weight an important cause the metabolic syndrome in adult. Protein depletion during gestation rat females has been widely used as model IUGR. By transcriptome analysis control protein-deprived placentas, we were able identify 2543 transcripts modified more than 2.5 fold (1347 induced 1196 repressed). Automatic...
Preeclampsia (PE) and vascular intra-uterine growth restriction (vIUGR) are two pathological obstetrical conditions originating from placental dysfunction. Recently, methylation changes at the level have been shown to be indicative of these diseases. The alteration such epigenetic marks is therefore a novel pathway that might critical for pathologies. Here, we identified region located in distal promoter T-box-containing transcription factor TBX15 differentially methylated placentas....
Analgesics are one of the most prescribed drugs during postpartum period to prevent and treat pain inflammatory disease. The focus on analgesics breastfeeding has increased because lack information fatal codeine intoxication in a breastfed neonate. Ibuprofen an advantageous benefit-risk ratio profile compared with codeine. There is drug transfer into human milk, thus ibuprofen intake may be debated. Consequently, there dilemma whether terminate or therapy. objective this study was determine...
Abstract Exclusive breastfeeding is recommended for children the first 4 to 6 months of life, with complementary foods added thereafter. It most ecological way protecting child's and mother's health. Training health professionals required avoid transmitting inconsistent information in 3 areas: 1) implementing these predictors: safe skin‐to‐skin, breastfeed, rooming‐in 24/7; 2) teaching monitoring: i) early signs waking feeding rhythms, ii) positioning latching, iii) effective transfer; 3)...