A5049067594- Birth, Development, and Health
- Gestational Diabetes Research and Management
- Obesity, Physical Activity, Diet
- Epigenetics and DNA Methylation
- Nutritional Studies and Diet
- Pregnancy and preeclampsia studies
- Diet and metabolism studies
- Health, Medicine and Society
- Child Nutrition and Water Access
- Obesity and Health Practices
- Folate and B Vitamins Research
- Health, Environment, Cognitive Aging
- Healthcare Systems and Practices
- Breastfeeding Practices and Influences
- Neonatal Respiratory Health Research
- Prenatal Substance Exposure Effects
- Neuroscience of respiration and sleep
- Maternal Mental Health During Pregnancy and Postpartum
- Nutrition and Health in Aging
- Thyroid Cancer Diagnosis and Treatment
- Bone health and osteoporosis research
- Family and Patient Care in Intensive Care Units
- Infant Development and Preterm Care
- Thyroid Disorders and Treatments
- Psychosocial Factors Impacting Youth
Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement
2020-2025
Université Paris Cité
2019-2025
Inserm
2019-2025
Centre de Recherche Épidémiologie et Statistique
2020-2025
Sorbonne Paris Cité
2021-2025
Université Sorbonne Paris Nord
2023-2025
Sorbonne Université
2023-2025
University College Dublin
2021-2023
Sage (United Kingdom)
2015
Université de Bretagne Occidentale
2015
OBJECTIVES Investigate associations of different family healthy lifestyle scores (HLS) during the first 1000 days with childhood overweight and obesity (OWOB). METHODS Cohort-specific analyses were conducted on participants (n = 25 006) from 4 European birth cohorts (The study pre- early postnatal determinants child health development [EDEN], Elfe, France; Generation R, Netherlands; Lifeways, Ireland). Three composite HLSs calculated: a maternal pregnancy HLS based prepregnancy body mass...
Abstract Background This study aimed to explore socioecological correlates of parental lifestyle patterns during pregnancy, an overlooked topic except for individual socioeconomic factors. Methods We used data from three European mother-offspring cohorts participating in the EndObesity Consortium [EDEN, France, n = 1,962; Generation R, Netherlands, 8,765; and Lifeways, Ireland, 932]. In previous principal component analysis, we identified two separate characterised by: 1) “high smoking,...
High prevalence of overweight and obesity already observed in preschool children suggests the involvement early-life risk factors. Preconception period pregnancy are crucial windows for implementation child prevention interventions with parental lifestyle factors as relevant targets. So far, most studies have evaluated their role separately, only a few having investigated potential synergistic effect on childhood obesity. Our objective was to investigate patterns preconception periods...
BackgroundA high prevalence of excess weight in children younger than 5 years suggests the involvement early-life risk factors. The preconception and pregnancy periods are crucial stages for implementation interventions to prevent childhood obesity. Most studies so far have evaluated effects factors separately, with only a few investigating combined effect parental lifestyle Our objective was fill literature gap regarding study their association overweight after age years.MethodsWe...
Abstract Context Maternal dysglycaemia and prepregnancy obesity are associated with adverse offspring outcomes. Epigenetic mechanisms such as DNA methylation (DNAm) could contribute. Objective To examine relationships between maternal glycaemia, insulinemic status, dietary glycemic indices during pregnancy an antenatal behavioral-lifestyle intervention newborn DNAm. Methods We investigated 172 women from a randomized controlled trial of lifestyle in pregnant who were overweight or obese....
Abstract These clinical practice guidelines from the French National College of Midwives (CNSF) are intended to define messages and preventive interventions be provided women co‐parents by different professionals providing care or their children during perinatal period. divided into 10 sections, corresponding 4 themes: 1/ adaptation maternal behaviors (physical activity, psychoactive agents); 2/ dietary behaviors; 3/ household exposure toxic substances (household uses, cosmetics); 4/...
Few studies have evaluated the role of methylation-pathway nutrients involved in fetal growth (B vitamins, choline, betaine, and methionine). These one-carbon metabolism (OCM) are essential for DNA methylation periconception period. We aimed to characterize dietary patterns 1638 women from EDEN mother-child cohort year before pregnancy according contribution OCM study association such with anthropometric measurements at birth. Dietary intake was assessed by using a semi-quantitative food...
The preconception period represents an important window for foetal and epigenetic programming. Some micronutrients (B vitamins, choline, betaine, methionine) implicated in one-carbon metabolism (OCM) are essential major processes that take place early pregnancy. However, few studies have evaluated the implication of placental DNA methylation. We investigated whether intake OCM nutrients year before pregnancy was associated with methylation EDEN mother-child cohort. Maternal dietary assessed...
Background Weight-control interventions in pregnant women with overweight or obesity have limited effectiveness for fetal growth and birth outcomes. Interventions prevention programs aiming at the pre-pregnancy period should be considered. However, how woman's weight change before pregnancy affects is not known. We investigated association between over year weight. Methods findings used inclusion data of 16,395 from ELFE French national cohort, a nationally representative cohort which...
Early-life nutritional exposures may contribute to offspring epigenetic modifications. However, few studies have evaluated parental dietary quality effects on DNA methylation (DNAm).
Abstract Women with thyroid diseases at the beginning of pregnancy may have suboptimal hormone levels because potential difficulties in compensating for physiological changes occurring pregnancy. Our objective was to study association between preexisting diseases, complications, and neonatal anthropometry. In total, 16,395 women from ELFE French longitudinal birth cohort were included, 273 declared pre-pregnancy diseases. Associations investigated multivariable regression models, adjustment...
Adequate maternal nutrition is crucial for a healthy pregnancy and optimal fetal growth. Many women in France of childbearing age start their an unfavorable nutritional status. Recent studies highlight the value paying attention to weight issues from preconceptional period. It important call need folate supplementation promote varied balanced diet throughout cover essential needs.
Abstract Background The high prevalence of overweight and obesity in young children suggests the involvement early life exposures. Based on Developmental Origins Health Disease paradigm, we investigated associations healthy lifestyle (HL) behaviours around first 1000 days with adiposity weight status throughout childhood. Methods Cohort-specific analyses were conducted four European birth cohorts (EDEN, Elfe, France; Generation R, Netherlands; Lifeways, Ireland), implementing a harmonized...
Abstract An inverse social gradient in early childhood overweight has been consistently described high-income countries; however, less is known about the role of migration status. We studied patterning preschool children according to mother’s socio-economic and background. For 9250 French ELFE birth cohort with body mass index collected at age 3.5 years, we used nested logistic regression investigate association status maternal educational level, occupation, household income Overall, 8.3%...
Abstract An inverse social gradient in early childhood overweight has been consistently described high-income countries; however, less is known about the role of migration status. We aimed to study patterning preschool children according mother’s socio-economic and background. For 9,250 French ELFE birth cohort with body mass index collected at 3.5 years, we used nested logistic regression investigate association status (IOTF definition) maternal educational level, occupation, household...
Abstract Background There is growing evidence that family lifestyle patterns in early life are associated with the risk of child obesity. However, beyond influence socio-economic position, scarce studies on social determinants such patterns. The aim was therefore to investigate socio-ecological correlates parental pregnancy. Methods We selected 1,110 families from EDEN birth cohort, recruited two maternity hospitals France between 2003 and 2006. In a previous work, we identified...