A5057618545- Clinical Laboratory Practices and Quality Control
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Birth, Development, and Health
- Lipoproteins and Cardiovascular Health
- Vitamin D Research Studies
- Trace Elements in Health
- Gestational Diabetes Research and Management
- Meta-analysis and systematic reviews
- Diabetes Treatment and Management
- Health Systems, Economic Evaluations, Quality of Life
- Heavy Metal Exposure and Toxicity
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Diabetes Management and Research
- Nutritional Studies and Diet
- Parathyroid Disorders and Treatments
- Healthcare cost, quality, practices
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Electrolyte and hormonal disorders
- Diabetes and associated disorders
- Bone health and osteoporosis research
- Renal function and acid-base balance
- Statistical Methods in Clinical Trials
- Clinical practice guidelines implementation
- Pregnancy and preeclampsia studies
University College Dublin
2016-2025
St. Vincent's University Hospital
2015-2024
National Maternity Hospital
2023-2024
Australian and New Zealand Intensive Care Society
2024
Monash University
2024
Rowan University
2024
ORCID
2021
Centre Hospitalier de l’Université de Montréal
2021
Charing Cross Hospital
2017-2020
West Suffolk NHS Foundation Trust
2018
The in-utero environment affects fetal development; it is vital to understand how maternal diet during pregnancy influences childhood body composition. While research indicates that triglycerides in hyperglycaemic women may increase birth weight, little known about this relationship euglycemic women. This study examines the between blood lipid status and infant adiposity up 2 years of age.Data from 331 mother-child pairs ROLO longitudinal cohort was analysed. Maternal dietary intakes were...
Copper is an essential cofactor for many enzymes, including cytochromes, but it toxic in its unbound form. The vast majority of serum copper transported bound to ceruloplasmin; the rest albumin, transcuprein, and copper–amino acid complexes. Wilson disease, autosomal recessive disorder with a frequency 1 30 000 100 live births, caused by mutations P-type ATPase that prevent incorporation into ceruloplasmin (1)(2). deposition occurs hepatic parenchymal cells, brain, periphery iris, kidney....
Pregnancy is a time of altered metabolic functioning and maternal blood lipid profiles change to accommodate the developing fetus. While these changes are physiologically necessary, lipids concentrations have been associated with adverse pregnancy outcomes such as gestational diabetes, pregnancy-induced hypertension high birth weight. As not routinely measured during pregnancy, there limited information on what considered normal in fetal blood. Data from 327 mother-child pairs ROLO...
External Quality Assurance (EQA) is vital to ensure acceptable analytical quality in medical laboratories. A key component of an EQA scheme performance specification (APS) for each measurand that a laboratory can use assess the extent deviation obtained results from target value. consensus conference held Milan 2014 has proposed three models set APS and these be applied setting EQA. goal arising this harmonisation between different schemes deliver consistent messages laboratories...
Background— Smoking is a potent cardiovascular risk factor and associated with proinflammatory prothrombotic responses. The CD40/CD40 ligand (CD40L) dyad platelet-monocyte aggregation mediate range of processes thought to be important in atherothrombosis. We investigated whether expression the CD40/CD40L are altered cigarette smokers. Methods Results— C-reactive protein (CRP), soluble (s) CD40L, surface CD40L on platelets T cells CD40 monocytes aggregates were compared 25 smokers age-...
The role of clinical pathologists or laboratory-based physicians is being challenged on several fronts-exponential advances in technology, increasing patient autonomy exercised the right to directly request tests and use non-medical specialists as substitutes. In response, have focused their energies pre-analytical postanalytical phases Laboratory Medicine thus emphasising essential individualised medical interpretation complex laboratory results. Across European Union, doctors enshrined...
This phase 1 trial assessed the safety, pharmacokinetics, and preliminary antitumor activity of RO7297089, an anti-BCMA/CD16a bispecific antibody.RO7297089 was administered weekly by intravenous infusion to patients with relapsed/refractory multiple myeloma. The starting dose 60 mg in this dose-escalation study utilizing a modified continual reassessment method overdose control model.Overall, 27 were treated at doses between 1850 mg. maximally due excipients formulation that did not allow...
To examine the efficacy and tolerability of rosuvastatin 5 mg at daily non-daily dosing regimens.A retrospective survey was conducted nine primary, secondary tertiary healthcare centres in United Kingdom.Changes lipid fractions from baseline values after more than 3 months' treatment.A total 325 patients were identified. These aged 63 ± 10 years, 50% male prescription mostly for primary prevention cardiovascular disease (CVD) (59%). Co-morbidities included: established CVD present 41%, type...
There is a requirement for accredited laboratories to participate in external quality assessment (EQA) schemes, but there wide variation understanding as what required by the and scheme providers fulfilling this. This not helped diversity of language used connection with EQA; Proficiency testing (PT), EQA programmes, each which have different meanings offerings context improving laboratory quality. We examine these differences, identify factors are important supporting within clinical should...
High blood pressure (BP) in pregnancy is associated with significant adverse outcomes. In nonpregnant populations, the DASH (Dietary Approaches to Stop Hypertension) diet reductions pressure. The present study investigated relationship between dietary pattern and maternal BP pregnancy.This an observational of 511 women who participated ROLO (Randomized cOntrol trial LOw glycaemic index for prevention recurrence macrosomia), 2007-2011, Dublin, Ireland. Auscultatory pressure, systolic (SBP)...
The aim of the present study was to investigate associations between lifetime breastfeeding behaviors and cardiovascular risk in later reproductive years.
Since the onset of COVID-19 pandemic in 2020, there have been plausible suggestions about need to augment vitamin D intake by supplementation order prevent SARS-CoV2 infection and reduce mortality. Some groups advocated for all adults, but governmental agencies targeted supplementation. We sought explore effect on both status dose new-to-market supplements.