A5073459428- Neonatal Respiratory Health Research
- Neonatal and fetal brain pathology
- Respiratory Support and Mechanisms
- Hemodynamic Monitoring and Therapy
- Neonatal Health and Biochemistry
- Traumatic Brain Injury and Neurovascular Disturbances
- Retinopathy of Prematurity Studies
- Neuroscience of respiration and sleep
- Non-Invasive Vital Sign Monitoring
- COVID-19 Clinical Research Studies
- Infant Development and Preterm Care
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Gallbladder and Bile Duct Disorders
- Neonatal and Maternal Infections
- Long-Term Effects of COVID-19
- Infant Nutrition and Health
- Optical Imaging and Spectroscopy Techniques
- Child Abuse and Related Trauma
- Kawasaki Disease and Coronary Complications
- Vascular Malformations and Hemangiomas
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cardiovascular Issues in Pregnancy
- Neurological Complications and Syndromes
Nottingham University Hospitals NHS Trust
2007-2024
Nottingham City Hospital
2019-2023
University of Nottingham
2010
Queen's Medical Centre
2002-2009
Queen's University
2003-2005
University of Liverpool
1991-2001
Liverpool Women's Hospital
1998-2001
University of Manchester
1998
St. Mary’s Hospital
1996-1998
Alder Hey Children's Hospital
1991
The clinically appropriate range for oxygen saturation in preterm infants is unknown. Previous studies have shown that had reduced rates of retinopathy prematurity when lower targets were used.
<h3>AIMS</h3> To assess whether changes in survival over time infants of 23 to 25 weeks gestational age were accompanied by the incidence disability childhood during an 11 year period. <h3>METHODS</h3> Obstetric and neonatal variables having strongest association with both discharge from a regional medical unit neurodevelopmental 192 gestation, born 1984 1994, studied as group two cohorts (1984 1989 n = 96 1990 1994 96). The data collected included CRIB (clinical risk index for babies)...
<h3>BACKGROUND</h3> Intramuscular supplementation with vitamin A in large doses may reduce the incidence of chronic lung disease. <h3>AIM</h3> To investigate whether oral would disease a group extremely low birthweight infants. <h3>METHODS</h3> Infants birth weight < 1000 g were randomised at to receive (5000 IU/day) or placebo for 28 days. The primary outcome was oxygen dependency days age death. <h3>RESULTS</h3> total 154 infants randomised; 77 received (median (interquartile range) 806...
Cerebral fractional oxygen extraction (FOE) represents the balance between cerebral delivery and consumption. This study aimed to determine FOE in preterm infants during hypotension, moderate anemia, with changes PaCO 2 . Three groups of neonates were studied: stable control (n = 43), anemic 46), hypotensive 19). was calculated from arterial saturation measured by pulse oximetry, venous using near infrared spectroscopy partial jugular occlusion. Mean ± SD similar (0.292 0.06), (0.310 0.08; P...
Background: Peripheral fractional oxygen extraction (FOE) may be a better indicator of the need for transfusion than haemoglobin concentration (Hb) because it is measure adequacy delivery to meet demand. A randomised controlled trial use peripheral FOE guide blood transfusions in preterm infants was carried out test this hypothesis. Method: Infants less 1500 g birth weight who were stable and 2 weeks old receive guided by either conventional protocol based on Hb (conventional group) or...
<h3>Importance</h3> Feeding intolerance is a common condition among preterm infants owing to immaturity of the gastrointestinal tract. Enteral insulin appears promote intestinal maturation. The concentration in human milk declines rapidly post partum and absent formula; therefore, recombinant (rh) for enteral administration as supplement formula may reduce feeding infants. <h3>Objective</h3> To assess efficacy safety 2 different dosages rh both formula. <h3>Design, Setting, Participants</h3>...
Cerebral blood flow (CBF) is known to be low in newborn infants, but this has not been shown damaging. The purpose of study was investigate the relationships between cerebral haemoglobin flow, oxygen delivery, consumption, venous saturation, and fractional extraction (OEF) newborn, preterm infants. Measurements were made by near-infrared spectroscopy 13 very preterm, extremely birth weight infants (median gestation 25 weeks) during first 3 days after birth. There a negative correlation...
Objective: To see whether there was a link between blood transfusion and lipid peroxidation as measured by urinary malondialdehyde (MDA) concentration in preterm infants. Methods: Urine samples were collected before after transfusions Twenty episodes studied 12 infants (some on more than one occasion). two who had not received used controls. All less 1500 g birth weight. Urinary MDA using thiobarbituric acid assay expressed nmol/mg creatinine. Results: The median (interquartile range) 9.1...
Several studies of peripheral measurements with near infrared spectroscopy (NIRS) and venous or arterial occlusion have been performed in neonates. Results variable. Reasons include differences patient populations, technical aspects the devices used way were made. It is therefore important that there should be common elements for measurement protocols. This statement proposes a standardised approach to allow comparison between different study populations devices.
<h3>BACKGROUND</h3> Femoral vessel catheterisation is generally avoided in the neonatal period because of technical difficulties and fear complications. <h3>AIM</h3> To review use femoral arterial venous catheters inserted percutaneously on intensive care unit. <h3>METHODS</h3> Infants admitted to one two regional units who underwent were identified. Information collected included basic details, indication for insertion catheter, type catheter technique, duration use, any related...
Cerebral fractional oxygen extraction (FOE) was monitored in 30 children, using near infrared spectroscopy during cardiopulmonary bypass, to investigate the effect of hypothermia and circulatory arrest. One group children (n = 15) underwent profound with total arrest 8) or continuous flow 7). Another 15), whom only one had arrest, mild 6) moderate 9) hypothermia. The mean FOE (SD) before bypass 0.35 (0.12) this correlated negatively preoperative arterial content (<i>r</i>=−0.58). Between...
A wide spectrum of intracranial injuries has been described as complicating difficult birth, particularly following instrumental delivery. We describe five children in whom isolated cortical tears were observed on MRI. Four cases characterised by a None the developed long-term neurological sequelae. As far we are aware, cerebral have not reported previously although recognition this injury pattern is important because its possible misinterpretation marker non-accidental head injury. Other...
This book is intended to provide a basic course in mathematics and statistics. It written for engineers scientists (implying non-mathematicians) this end it adopts conversational rather than rigorous approach. The first part of the concerned with calculus which developed from principles, through techniques applications differentiation intergration, simple ordinary differential equations.
<h3>Background and aims</h3> The optimal target range for pulse oximeter saturation (SpO<sub>2</sub>) in extremely preterm infants is unknown. BOOST-II UK one of 5 international studies that have recently investigated this. <h3>Methods</h3> Preterm born before 28 weeks’ gestation were randomised within 24 h birth to an SpO<sub>2</sub> 85–89% or 91–95%. intervention used masked offset oximeters was continued until 36 gestation. primary outcome a composite death serious neurosensory disability...