Hedley Emsley
A5029502706- Acute Ischemic Stroke Management
- Parkinson's Disease Mechanisms and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Epilepsy research and treatment
- Cerebrovascular and Carotid Artery Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Advanced Neuroimaging Techniques and Applications
- Stroke Rehabilitation and Recovery
- Pharmacological Effects and Toxicity Studies
- Neurological and metabolic disorders
- Neurological disorders and treatments
- S100 Proteins and Annexins
- Advanced MRI Techniques and Applications
- Venous Thromboembolism Diagnosis and Management
- Neurological Disease Mechanisms and Treatments
- Neurological Disorders and Treatments
- Intracranial Aneurysms: Treatment and Complications
- Neurosurgical Procedures and Complications
- Telemedicine and Telehealth Implementation
- Multiple Sclerosis Research Studies
- Emergency and Acute Care Studies
- Diabetes Treatment and Management
- Cerebral Venous Sinus Thrombosis
- Neurological Complications and Syndromes
- HIV-related health complications and treatments
Lancaster University
2017-2025
Lancashire Teaching Hospitals NHS Foundation Trust
2016-2025
Royal Preston Hospital
2015-2024
Lancaster University Ghana
2022-2024
Manchester Academic Health Science Centre
2020-2023
University of Manchester
2014-2023
Manchester University
2022
Campbell Collaboration
2021
Furness College
2020
Royal Hallamshire Hospital
2017
Cerebral ischaemia initiates an inflammatory response in the brain and periphery. We assessed relationship between peak values of plasma interleukin-6 (IL-6) first week after ischaemic stroke, with measures stroke severity outcome. Thirty-seven patients were prospectively recruited. Plasma IL-6, other markers peripheral inflammation, measured at pre-determined timepoints onset. Primary analyses association IL-6 concentration both modified Rankin score (mRS) 3 months computed tomography (CT)...
The cytokine interleukin (IL)-1 mediates ischaemic brain damage in rodents. endogenous, highly selective, IL-1 receptor antagonist (IL-1ra) protects against cerebral injury a range of experimental settings, and IL-1ra causes marked reduction cell death when administered peripherally or at delay transient ischaemia. We report here the first randomised, double blind, placebo controlled trial recombinant human (rhIL-1ra) patients with acute stroke.Patients within 6 hours onset symptoms stroke...
Cerebral microbleeds are a potential neuroimaging biomarker of cerebral small vessel diseases that prone to intracranial bleeding. We aimed determine whether presence can identify patients at high risk symptomatic haemorrhage when anticoagulated for atrial fibrillation after recent ischaemic stroke or transient attack.
Blood-brain barrier (BBB) disruption has been noted in animal models of Parkinson's disease (PD) and forms the basis vascular hypothesis neurodegeneration, yet clinical studies are lacking.To determine alterations BBB integrity PD, with comparison to cerebrovascular disease.Dynamic contrast enhanced magnetic resonance images were collected from 49 PD patients, 15 control subjects [control positive (CP)] 31 healthy negative (CN)], all groups matched for age. Quantitative maps agent transfer...
<h3>AIMS</h3> To assess whether changes in survival over time infants of 23 to 25 weeks gestational age were accompanied by the incidence disability childhood during an 11 year period. <h3>METHODS</h3> Obstetric and neonatal variables having strongest association with both discharge from a regional medical unit neurodevelopmental 192 gestation, born 1984 1994, studied as group two cohorts (1984 1989 n = 96 1990 1994 96). The data collected included CRIB (clinical risk index for babies)...
<h3>Objective:</h3> In an international collaborative multicenter pooled analysis, we compared mortality, functional outcome, intracerebral hemorrhage (ICH) volume, and hematoma expansion (HE) between non–vitamin K antagonist oral anticoagulation–related ICH (NOAC-ICH) vitamin antagonist–associated (VKA-ICH). <h3>Methods:</h3> We all-cause mortality within 90 days for NOAC-ICH VKA-ICH using a Cox proportional hazards model adjusted age; sex; baseline Glasgow Coma Scale score, location, log...
To investigate HIV, its treatment, and hypertension as stroke risk factors in Malawian adults.We performed a case-control study of 222 adults with acute stroke, confirmed by MRI 86%, 503 population controls, frequency-matched for age, sex, place residence, using Global Positioning System random selection. Multivariate logistic regression models were used comparisons.HIV infection (population attributable fraction [PAF] 15%) (PAF 46%) strongly linked to stroke. HIV was the predominant factor...
To compare intracerebral hemorrhage (ICH) volume and clinical outcome of non-vitamin K oral anticoagulants (NOAC)-associated ICH to warfarin-associated ICH.In this multicenter cross-sectional observational study patients with anticoagulant-associated ICH, consecutive NOAC-ICH were compared those warfarin-ICH selected from a population 344 ICH. was measured by an observer blinded details. Outcome measures adjusted for confounding factors.We 11 52 warfarin-ICH. The median 2.4 mL (interquartile...
ABSTRACT Background Brain structure abnormalities throughout the course of Parkinson's disease have yet to be fully elucidated. Objective Using a multicenter approach and harmonized analysis methods, we aimed shed light on stage‐specific profiles pathology, as suggested by in vivo neuroimaging. Methods Individual brain MRI clinical data from 2357 patients 1182 healthy controls were collected 19 sources. We analyzed regional cortical thickness, surface area, subcortical volume using...
Titin gene (TTN) mutations have been described in eight families with hereditary myopathy early respiratory failure (HMERF). Some of the original patients had features resembling myofibrillar (MFM), arguing that TTN could be a much more common cause inherited muscle disease, especially presence involvement.We studied 127 undiagnosed clinical presentation compatible MFM. Sanger sequencing for two previously HMERF (p.C30071R 119th fibronectin-3 (FN3) domain, and p.R32450W kinase domain) was...
Idiopathic Parkinson's disease (IPD) is the second most common neurodegenerative disease, yet effective modifying treatments are still lacking. Neurodegeneration involves multiple interacting pathological pathways. The extent to which neurovascular mechanisms involved not well defined in IPD. We aimed determine whether novel magnetic resonance imaging (MRI) techniques, including arterial spin labelling (ASL) quantification of cerebral perfusion, can reveal altered status (NVS) Fourteen...
Neurovascular changes are likely to interact importantly with the neurodegenerative process in idiopathic Parkinson’s disease (IPD). Markers of neurovascular status (NVS) include white matter lesion (WML) burden and arterial spin labelling (ASL) measurements cerebral blood flow (CBF) arrival time (AAT). We investigated NVS IPD, including an analysis IPD clinical phenotypes, by comparison two control groups, one a history cerebrovascular (CVD) (control positive, CP) without CVD negative, CN)....
Background and Purpose: The causes of recurrent ischemic stroke despite anticoagulation for atrial fibrillation are uncertain but might include small vessel occlusion. We investigated whether magnetic resonance imaging markers cerebral disease (SVD) associated with risk during follow-up in patients anticoagulated after recent or transient attack. Methods: analyzed data from a prospective multicenter inception cohort study attack (CROMIS-2 [Clinical Relevance Microbleeds Stroke Study]). rated...
The progression of Parkinson's disease (PD) is associated with microstructural alterations in neural pathways, contributing to both motor and cognitive decline. However, conflicting findings have emerged due the use heterogeneous methods small studies. Here we performed a large diffusion MRI study PD, integrating data from 17 cohorts worldwide, identify stage-specific profiles white matter differences. Diffusion-weighted 1654 participants diagnosed PD (age: 20–89 years; 33% female) 885...
As critical mediators of local and systemic inflammatory responses, cytokines are produced in the brain following ischaemic stroke. Some have been detected circulation stroke patients, but their role source is unclear. Focusing primarily on interleukin(IL)-1-related mechanisms, we serially measured plasma markers, production by whole blood, from 36 patients recruited within 12 h followed up to 1 year after acute (AIS). Admission IL-1 receptor antagonist (IL-1ra) concentration was elevated,...