A5074851198- Pregnancy and preeclampsia studies
- HIV Research and Treatment
- Nitric Oxide and Endothelin Effects
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Birth, Development, and Health
- Cardiovascular Issues in Pregnancy
- HIV/AIDS drug development and treatment
- Periodontal Regeneration and Treatments
- Neonatal Respiratory Health Research
- Estrogen and related hormone effects
- Phosphodiesterase function and regulation
- dental development and anomalies
- Reproductive System and Pregnancy
- Neuroendocrine regulation and behavior
- Mesenchymal stem cell research
- Protein Kinase Regulation and GTPase Signaling
- Immune Cell Function and Interaction
- Pregnancy and Medication Impact
- Oral and gingival health research
- Molecular Biology Techniques and Applications
- RNA and protein synthesis mechanisms
- Tissue Engineering and Regenerative Medicine
- Cleft Lip and Palate Research
- Growth Hormone and Insulin-like Growth Factors
- Oral and Maxillofacial Pathology
Hôpital Charles-Foix
2013-2024
Inserm
2005-2024
Sorbonne Université
2012-2024
Assistance Publique – Hôpitaux de Paris
2010-2024
Université Paris Cité
2002-2024
Sorbonne Paris Cité
2012-2024
Centre de Recherche des Cordeliers
2011-2024
Pitié-Salpêtrière Hospital
2019-2022
Délégation Paris 5
1995-2019
Centre National de la Recherche Scientifique
1978-2015
The gum has an exceptional capacity for healing. To examine the basis this property and explore potential of conferring it to organs with inferior healing capacity, we sought presence progenitor cells in gingival connective tissue. Colony-forming units fibroblast-enriched from fibroblast cultures were assessed expression membrane markers mesenchymal stem cells; differentiate into osteoblasts, chondroblasts, adipocytes; engraftment efficiency after vivo transfer. On their ability several...
Dental anomalies occur frequently in a number of genetic disorders and act as major signs diagnosing these disorders. We present definitions the most common dental propose classification usable diagnostic tool by dentists, clinical geneticists, other health care providers. The are part series Elements Morphology have been established after careful discussions within an international group experienced dentists geneticists. system was elaborated French collaborative network "TÊTECOU"...
Background: Extracellular matrix (ECM) plays a pivotal role in many physiological processes. ECM macromolecules and associated factors differ according to tissues, impact cell differentiation, tissue homeostasis. Dental pulp may from other oral tissues mineralization. Thus, the present study aimed identify matrisome of proteins derived human dental stem cells (DPSCs) its ability regulate mineralization even which do not respond assaults by mineralization, gingival fibroblasts (GF). Methods:...
Abstract Purpose of Review This work consists in a literature review on the current state knowledge regarding oral management patients with history head and neck cancer (HNC), corroborated by clinical cases illustrated clear infographic summaries. It aims to provide healthcare professionals comprehensive overview health status HCN patients. Recent Findings Head cancers (HNCs) represent seventh most common type worldwide, over 660,000 annual new cases. Despite significant negative impact HNCs...
The distributions of the mRNAs for estrogen receptors (ERα and ERβ) their binding properties in myometria pregnant nonpregnant women leiomyoma were studied. RT-PCR analysis indicated that term pregnancy had little ERα mRNA, whereas amounts ERβ or appeared to be similar. Both mRNA greater certain than normal myometria. kinetics revealed two specific sites (with high low affinity) 17β-estradiol present myometrium. Only low-affinity detectable late-pregnancy leiomyoma, capacities increased two-...
Polyunsaturated fatty acids (PUFA) like arachidonic (C20:4) and docosahexaenoic (C22:6) are essential for harmonious fetal development. This study evaluates, at near term, the distributions of free (FFA) their carrier protein, alpha-fetoprotein (AFP) in maternal (M) circulation (umbilical arteries (A) vein (V)), focusing on feto-material interface where intervillous blood (I) contacts trophoblast. FFA concentrations were similar, while those umbilical 2- to 4-fold lower (P < 0.001). There...
Neural crest (NC)-derived stem cells (NCSC) have an exceptionally wide differentiation potential, but their use in regenerative therapy has been hampered by scarcity adult tissues and complex isolation protocols.Human oral mucosal gingiva may provide attractive source of these as it contains NC-derived cells, the tissue is easily accessible wound healing fast scarless with very little morbidity.To this end, we first investigated whether are retained examining 8-months-old NC-reporter...
Journal Article Effect of Immunization with Inactivated gp120-Depleted Human Immunodeficiency Virus Type 1 (HIV-1) Immunogen on HIV-1 Immunity, Viral DNA, and Percentage CD4 Cells Get access Richard J. Trauger, Trauger Immune Response Corporation, Carlsbad, California; Products Limited Rhone-Poulenc Rorer Inc., Collegeville, Pennsylvania Reprints or correspondence: Dr. Corp., 5935 Darwin Ct., CA 92008. Search for other works by this author on: Oxford Academic PubMed Google Scholar Francois...
Summary: In 1987, exploratory clinical studies were initiated to determine whether the development of AIDS in HIV-infected individuals might be delayed or prevented by immunization with an inactivated HIV preparation. Preclinical had shown preparation safe and immunogenic. Twenty-three patients biopsy-confirmed persistent generalized lymphadenopathy (CDC III) two asymptomatic infection CD4 lymphocyte counts between 135 769/mm3 studied, whom eight (32%) additional HIV-related symptoms. Over a...
Human gingival stem cells (HGSCs) can be easily isolated and manipulated in culture to investigate their multipotency. Osteogenic differentiation of bone-marrow-derived mesenchymal stem/stromal has been well documented. HGSCs derive from neural crests, however, capacity not fully established. The aim the present report was whether induced differentiate osteoblasts chondrocytes. were cultured either a classical monolayer or three-dimensional floating micromass pellet cultures specific media....
Introduction: Sialolithiasis is defined by the presence of a calculus within salivary gland or its excretory system. It primarily affects submandibular at frequency 80%. Involving many factors, exact aetiology and pathogenesis calculi remain to be discussed. Body: The purpose this article expose different aspects pathology. Aetiological diagnostic approach which requires use imaging tests as well medical surgical management anterior sialolithiasis, will described. A decision tree regarding...
Craniofacial and jaw bones have unique physiological specificities when compared to axial appendicular bones. However, the molecular profile of osteoblast (OB) remains incomplete. The present study aimed decipher bone site-specific profiles transcription factors (TFs) expressed in OBs vivo. Using RNA sequencing analysis, we mapped transcriptome confirmed from 2 different skeletal sites: mandible (Md) tibia (Tb). OB contains 709 TF genes: 608 are similarly Md-OB Tb-OB, referred as "OB-core";...
In human myometrium, the modulation of intracellular cAMP content resulting from agonist-mediated stimulation receptor-adenylyl cyclase complex is largely influenced by rate hydrolysis phosphodiesterase (PDE) isoenzymes. We have previously shown that PDE4 family contributes to predominant cAMP-hydrolyzing activity in myometrium and elevation PDE4B2 messenger RNA steady state level occurs pregnant myometrial tissue. present study, we used a model cells culture determine whether an elevated...