A5024615654- Gene expression and cancer classification
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Birth, Development, and Health
- Effects and risks of endocrine disrupting chemicals
- Biomedical Text Mining and Ontologies
- Computational Drug Discovery Methods
- Per- and polyfluoroalkyl substances research
- Immune Cell Function and Interaction
- Scientific Computing and Data Management
- History and advancements in chemistry
- Microbial Metabolic Engineering and Bioproduction
- Health, Environment, Cognitive Aging
- melanin and skin pigmentation
- Carcinogens and Genotoxicity Assessment
- Cancer-related molecular mechanisms research
- Molecular Biology Techniques and Applications
- Genetics, Bioinformatics, and Biomedical Research
- Vitamin D Research Studies
- Genetic and phenotypic traits in livestock
- Genetically Modified Organisms Research
- Allergic Rhinitis and Sensitization
- Genomics and Phylogenetic Studies
- Evolution and Genetic Dynamics
- Contact Dermatitis and Allergies
Institut de Recherche en Santé, Environnement et Travail
2015-2024
Constellium (France)
2020-2024
Université de Rennes
2015-2020
École des Hautes Études en Santé Publique
2018-2020
Inserm
2015-2020
Institut de Recherche en Informatique et Systèmes Aléatoires
2015-2019
Centre National de la Recherche Scientifique
2019
Institut national de recherche en informatique et en automatique
2015-2018
Abstract Motivation Recent advances in transcriptomics have enabled unprecedented insight into gene expression analysis at a single-cell resolution. While it is anticipated that the number of publications based on such technologies will increase next decade, there currently no public resource to centralize and enable scientists explore datasets published field reproductive biology. Results Here, we present major update ReproGenomics Viewer, cross-species cross-technology web-based...
Perfluorooctanesulfonic acid (PFOS) is a persistent anthropogenic chemical that can affect the thyroid hormone system in humans and animals. In adults, hormones (THs) are regulated by hypothalamic-pituitary-thyroid (HPT) axis, but also organs such as liver potentially gut microbiota. PFOS other xenobiotics therefore disrupt TH at various locations through different mechanisms. To start addressing this, we exposed adult male rats to 3 mg PFOS/kg/day for 7 days analysed effects on multiple...
We report the development of ReproGenomics Viewer (RGV), a multi- and cross-species working environment for visualization, mining comparison published omics data sets reproductive science community. The system currently embeds 15 related to gametogenesis from nine model organisms. Data have been curated conveniently organized into broad categories including biological topics, technologies, species publications. RGV's modular design both organisms genomic tools enables users upload compare...
Is the noncoding transcriptional landscape during spermatogenesis conserved between human and rodents?We identified a core group of 113 long RNAs (lncRNAs) 20 novel genes dynamically syntenically transcribed spermatogenesis.Spermatogenesis is complex differentiation process driven by tightly regulated highly specific gene expression program. Recently, several studies in various species have established that large proportion known lncRNAs are preferentially expressed meiosis spermiogenesis...
Primary cultures of Human Hepatocytes (PHH) are the gold standard to investigate drug-hepatotoxicity in vitro, however, large-scale studies using these primary liver cells not possible because shortage biopsies. HepaRG model is often considered as closest surrogate PHH for toxicity vitro. However, differentiated express very low levels cytochrome P450 2D6 (CYP2D6) protein, which essential biotransformation nearly 25% drugs on market. To overcome this limitation, infection progenitor were...
Changes in lymphocyte production patterns occurring across human ontogeny remain poorly defined. In this study, we demonstrate that lymphopoiesis is supported by three waves of embryonic, fetal, and postnatal multi-lymphoid progenitors (MLPs) differing CD7 CD10 expression their output CD127-/+ early lymphoid (ELPs). addition, our results reveal that, like the fetal-to-adult switch erythropoiesis, transition to life coincides with a shift from multilineage B lineage-biased an increase CD127+...
At the same time that toxicologists express increasing concern about reproducibility in this field, development of dedicated databases has already smoothed path toward improving storage and exchange raw toxicogenomic data. Nevertheless, none provides access to analyzed interpreted data as originally reported scientific publications. Given demand for information, we developed TOXsIgN, a repository TOXicogenomic sIgNatures.The TOXsIgN flexible environment facilitates online submission,...
Exposure to endocrine-disrupting chemicals (EDCs) during development may cause reproductive disorders in women. Although female endpoints are assessed rodent toxicity studies, a concern is that typical not sensitive enough detect of human health. If so, measured must be improved or new biomarkers effects included. Herein, we have characterized the dynamic transcriptional landscape developing rat ovaries exposed two well-known EDCs, diethylstilbestrol (DES) and ketoconazole (KTZ), by 3' RNA...
A short anogenital distance (AGD) in males is a marker for incomplete masculinization and predictor of adverse effects on male reproductive health. For this reason, AGD used to assess the endocrine disrupting potential chemicals risk assessment purposes. The molecular mechanisms underpinning chemically induced shortening AGD, however, remains unclear. Although it clear that androgen receptor-mediated signaling essential, evidence also suggest involvement other pathways. This study presents...
Exposure to perfluorooctanesulfonic acid (PFOS) has been associated with congenital heart disease (CHD) and decreased birth weight. PFOS exposure can disrupt signaling pathways relevant for cardiac development in stem cell-derived cardiomyocyte assays, such as the PluriBeat assay, where spheroids of human induced pluripotent cells (hiPSCs) differentiate into contracting cardiomyocytes. Notably, cell line origin also affect how assay responds chemical exposure. Herein, we examined effect on...
Among the 20 000 human gene products predicted from genome annotation, about 3000 still lack validation at protein level. We developed PepPSy, a user-friendly expression-based prioritization system, to help investigators determine in which tissues they should look for an unseen protein. PepPSy can also be used by biocurators revisit annotation of specific categories proteins based on 'omics' data housed system. In this study, it was prioritize 21 dubious protein-coding genes among 616...
Abstract Characterising known and new chemical compounds for skin sensitisation provides a basis the development of safer products where ingredients are exposed to skin. By including approaches, such as tiered testing strategies integrated data analysis, it is possible develop next generation adhering emerging regulations, scientific evidence animal welfare principles. To ensure integrity during assessment OECD characterisation guidelines Defined Approaches (DAs) uniform work-flows. In this...