A5008704226- Effects and risks of endocrine disrupting chemicals
- Thyroid Disorders and Treatments
- Birth, Development, and Health
- Environmental Toxicology and Ecotoxicology
- Pharmaceutical and Antibiotic Environmental Impacts
- Toxic Organic Pollutants Impact
- Mercury impact and mitigation studies
- Pesticide and Herbicide Environmental Studies
- Physiological and biochemical adaptations
- Estrogen and related hormone effects
- Human Health and Disease
- Vitamin D Research Studies
- Fluoride Effects and Removal
- Health, Environment, Cognitive Aging
- Chemical Analysis and Environmental Impact
- Growth Hormone and Insulin-like Growth Factors
- Vitamin C and Antioxidants Research
- Reproductive biology and impacts on aquatic species
- Pharmacological Effects and Assays
- Groundwater and Isotope Geochemistry
- Pesticide Residue Analysis and Safety
- Hormonal and reproductive studies
- Marine Biology and Environmental Chemistry
- Isotope Analysis in Ecology
- Per- and polyfluoroalkyl substances research
Aarhus University
2020-2024
University of Victoria
2024
University of Southern Denmark
2022-2023
University of Copenhagen
2015-2021
Frederiksberg Hospital
2016
University of California, Berkeley
2014-2015
Integra (United States)
2014
Plastic pollution has become a major concern on global scale. The plastic is broken down into minuscule particles, which have an impact the biosystems, however long-term impacts through entire generation largely unknown. Here, we present first whole study exposing fish to 500 nm polystyrene particle at environmentally relevant concentrations. Short- and adverse effects were investigated in zebrafish model organism using holistic multi-omics approach. particles accumulated yolk sac of young...
Perfluorooctanesulfonic acid (PFOS) is a persistent anthropogenic chemical that can affect the thyroid hormone system in humans and animals. In adults, hormones (THs) are regulated by hypothalamic-pituitary-thyroid (HPT) axis, but also organs such as liver potentially gut microbiota. PFOS other xenobiotics therefore disrupt TH at various locations through different mechanisms. To start addressing this, we exposed adult male rats to 3 mg PFOS/kg/day for 7 days analysed effects on multiple...
Abstract Early vertebrate development is partially regulated by thyroid hormones (THs). Environmental pollutants that interact with the TH system (TH system–disrupting chemicals [THSDCs]) can have massively disrupting effects on this essential phase. Eye of fish directly THs and can, therefore, be used as a thyroid‐related endpoint in endocrine disruptor testing. To evaluate THSDC‐induced eye malformations during early development, zebrafish ( Danio rerio ) embryos were exposed for 5 days...
Bisphenols are industrial chemicals that produced in large quantities and have been detected all parts of the environment as well a multitude different organisms including humans fish. Several bisphenols, such bisphenol A (BPA) F, shown to disrupt endocrine systems thereby affecting development reproduction. While numerous studies investigated effect bisphenols on estrogen signaling, their impact thyroid hormone system (THS), which is vital for neurodevelopment sensory development, has...
Man-made chemicals are a significant contributor to the ongoing deterioration of numerous ecosystems. Currently, risk assessment these is based on observations in single generation animals, despite potential adverse intergenerational effects. Here, we investigate effect fungicide prochloraz across three generations Daphnia magna. We studied both effects continuous exposure over all and first-generation (F0) two subsequent generations. Effects at different levels biological organization from...
Anuran metamorphosis is characterized by profound morphological changes including remodeling of tissues and organs. This transition initiated thyroid hormones (THs). However, the current knowledge changing levels THs during relies on pooled samples using methods known for high variability with sparse reporting measured variation. Moreover, establishing a clear linkage between key gene expression bioindicators TH throughout metamorphic process needed. Using state-of-the-art ultra-high...
Wildlife is exposed to mixtures of environmental contaminants that affect health and population dynamics. Exposure toxic heavy metals originating from anthropogenic sources may exert metabolic effects at even low exposure concentrations. Here we investigated the relationships between metal changes in migratory bird pink-footed goose (Anser brachyrhynchus). We used blood pellet plasma samples 27 free-ranging geese study (Cd, Cr, Hg, Pb) relation metabolome. The results relate concentrations...
Suboptimal iodine status is a prominent public health issue in several European coun-tries. Brown algae have high content that, upon intake, may exceed the recommended dietary intake level, but bioavailability has been reported to be lower than from potassium iodide (KI) and highly depends on species. Further, potential negative effects other components algae, such as cadmium (Cd) arsenic (As), also addressed. In this study, we observed of farmed sugar kelp (Saccharina latissima) KI female...
Gestating mice were exposed to three chemicals, tetrabromo-bisphenol A (TBBPA; 2 mg/kg/day), amitrole (25 and 50 mg/kg/day) pyraclostrobin (0.4 assess their capacity act as thyroid hormone disruptors compromise neurodevelopment. Propyl-thio-uracyl, a known pharmacological inhibitor of gland secretion, was used at both high low dose reference system disruptor (1 ppm, 1500 ppm). combination plasma metabolomics striatum transcriptomics revealed the induced change in pups postnatal stages....
Mice were exposed to a low dose of the model thyroid hormone disruptor, propylthiouracil. Although this had only modest effect on maternal hormones production, postnatal analysis pups' plasma by mass spectrometry and brain striatum RNA sequencing gave evidence lasting changes that could reflect an adverse neurodevelopment. Overall, these methods proved be sensitive enough detect minor disruptions signalling in vivo.
Traditionally applied methodology in environmental risk assessment (ERA) has fallen out of step with technological advancements and regulatory requirements, challenging effectiveness accuracy the assessments. Extensive efforts have been focused towards a transition to more data-driven mechanistically-based next generation assessment. Metabolomics can produce detailed comprehensive molecular insight into affected biochemical processes. Combining metabolomics toxicology help understand...
Highlights● Untargeted transcriptomics and metabolomics are sensitive, unbiased methods to detect toxicity● Maternal hypothyroxinemia due low-dose chemical exposure affects offspring● Compared thyroid hormones, other more sensitive biomarkers were uncovered with omics tools
Abstract Man-made chemicals are a significant contributor to the ongoing deterioration of ecosystems. Currently, risk assessment these is based on observations in single generation animals, despite potential adverse intergenerational effects. Here, we investigate effect fungicide prochloraz across three generations Daphnia magna. We studied both effects continuous exposure over all and first-generation (F0) two subsequent, non-exposed, generations. Effects at different levels biological...
Polyquaternium polymers are widely used in various applications, such as personal care products and wastewater treatment plants, eventually end up the aquatic environment. While have been perceived of low toxicological concern due to their size, several studies pointed towards cationic being toxic organisms – toxicity largely is determined by polymer charge density. The present study investigated polyquaternium mechanism action throughout lipidomic analysis changes immune-gene expression...
Polyquaternium polymers are widely used in various applications, such as personal care products and wastewater treatment plants, eventually end up the aquatic environment. While have been perceived of low toxicological concern due to their size, several studies pointed towards water-soluble cationic being toxic organisms – that toxicity largely is determined by polymer charge density. The present study investigated polyquaternium mechanism action throughout lipidomic analysis changes...