Marie Lefèvre

ORCID: 0009-0000-1194-8372
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About
Contact & Profiles
Research Areas
  • Noise Effects and Management
  • Vehicle Noise and Vibration Control
  • Air Quality and Health Impacts
  • Probiotics and Fermented Foods
  • Hearing Loss and Rehabilitation
  • Gastrointestinal motility and disorders
  • Acoustic Wave Phenomena Research
  • Congenital gastrointestinal and neural anomalies
  • Testicular diseases and treatments
  • Sleep and Work-Related Fatigue
  • Gut microbiota and health
  • Cardiovascular Health and Disease Prevention
  • Human Health and Disease
  • Infant Nutrition and Health
  • HIV/AIDS Research and Interventions
  • Injury Epidemiology and Prevention
  • Parasites and Host Interactions
  • Reproductive Health and Contraception
  • Pediatric health and respiratory diseases
  • Pelvic and Acetabular Injuries
  • Immune Cell Function and Interaction
  • IL-33, ST2, and ILC Pathways
  • Global Public Health Policies and Epidemiology
  • Environmental Justice and Health Disparities
  • Liver Disease Diagnosis and Treatment

Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
2013-2024

Université Claude Bernard Lyon 1
2016-2024

Université du Québec à Montréal
2023-2024

Université Gustave Eiffel
2020-2022

Lesaffre (France)
2015-2018

Sage (United Kingdom)
2015

Université de Bretagne Occidentale
2015

University of Oxford
2005

Bacillus probiotics health benefits have been until now quite poorly studied in the elderly population. This study aimed to assess effects of subtilis CU1 consumption on immune stimulation and resistance common infectious disease (CID) episodes healthy free-living seniors.One hundred subjects aged 60-74 were included this randomized, double-blind, placebo-controlled, parallel-arms study. Subjects consumed either placebo or probiotic (2.10(9) B. spores daily) by short periodical courses 10...

10.1186/s12979-015-0051-y article EN cc-by Immunity & Ageing 2015-12-01

Bacillus subtilis CU1 is a recently described probiotic strain with beneficial effects on immune health in elderly subjects. The following work describes series of studies supporting the safety for use as an ingredient food and supplement preparations. Using combination 16S rDNA gyrB nucleotide analyses, species was identified member complex (B. subsp. spizizenii). Further characterization organism at level achieved using random amplified polymorphic DNA polymerase chain reaction (RAPD PCR)...

10.1016/j.yrtph.2016.11.010 article EN cc-by-nc-nd Regulatory Toxicology and Pharmacology 2016-11-05

<h3>Objectives</h3> The largest study until now around 6 major European airports, the HYENA (HYpertension and Exposure to Noise near Airports) study, reported an excess risk of hypertension related long-term aircraft noise exposure. DEBATS (Discussion on health effects noise) investigated relationship between this exposure in men women French airports. <h3>Methods</h3> Blood pressure 1244 participants older than 18 years age was measured. Information about health, socioeconomic lifestyle...

10.1136/oemed-2016-103648 article EN Occupational and Environmental Medicine 2016-08-01

Many studies, including the HYENA and DEBATS showed a significant association between aircraft noise exposure risk of hypertension. Few studies have considered annoyance sensitivity as factors interest, especially in relation to hypertension risk, or mediating modifying factors. The present study aims 1) investigate sensitivity; 2) examine role modifier mediator these two levels hypertension.This included 6,105 residents ten European airports from studies. Information on annoyance,...

10.1016/j.envres.2020.110179 article EN cc-by-nc-nd Environmental Research 2020-09-10

<h3>Background</h3> Saliva cortisol is a possible marker of noise-induced stress and could then mediate the relation observed between exposure to aircraft or road traffic noise cardiovascular diseases. However, association transportation levels still unclear. The objective study was investigate variability saliva concentration as an indicator disturbed hypothalamus-pituitary-adrenal (HPA) axis regulation in long-term exposure. <h3>Methods</h3> samples were taken when awakening before going...

10.1136/oemed-2016-104208 article EN Occupational and Environmental Medicine 2017-04-25

Background: The effects of aircraft noise on psychological ill-health have not been largely investigated and remain to be discussed. No study has performed in France the health noise. Objectives: present aimed investigate relationship between dB terms annoyance populations living near airports France. Methods: A total 1244 individuals older than 18 three French (Paris–Charles de Gaulle, Lyon–Saint-Exupéry Toulouse–Blagnac) were randomly selected participate study. Information about their...

10.3390/ijerph15081642 article EN International Journal of Environmental Research and Public Health 2018-08-03

Background Although several cross-sectional studies have shown that aircraft noise exposure was associated with an increased risk of hypertension, a limited number longitudinal addressed this issue. This study is part the DEBATS (Discussion on health effect noise) research programme and aimed to investigate association between incidence hypertension. Methods In 2013, 1244 adults living near three major French airports were included in study. Systolic diastolic blood pressure, as well...

10.1136/oemed-2021-107921 article EN Occupational and Environmental Medicine 2022-01-19

Noise is a major public health issue because of its negative impacts on health, including annoyance, sleep disturbance, cardiovascular diseases and altered cognitive performance among children. Self-rated status (SRHS) can be considered as reliable indicator quality life, morbidity mortality but few studies have SRHS in relation to aircraft noise exposure. The present study aims investigate the association between this exposure people living near airports France, consider mediating or...

10.1186/s12889-020-10138-0 article EN cc-by BMC Public Health 2021-01-10

Preventive actions of probiotics as antidiarrheal agents are well documented, but their mechanisms poorly understood. Two selected probiotics, Bacillus subtilis CU1 and Lactobacillus plantarum CNCM I-4547, were tested in mouse experimental models diarrhea the possible action investigated. Diarrhea was induced mice by oral castor oil administration or i.v. injection LPS Salmonella enteritis. The drug loperamide used control. Fecal water excretion quantified for two hours paracellular...

10.3389/fmicb.2018.01537 article EN cc-by Frontiers in Microbiology 2018-07-10

Background: Exposure to aircraft noise has been shown have adverse effects on health, particularly sleep. nighttime clearly affects sleep architecture, as well subjective quality. Objectives: This study aimed investigate the relationship between exposure and quality in population living near airports France. Methods: A total of 1,244 individuals older than 18 three French (Paris-Charles de Gaulle, Lyon-Saint-Exupéry, Toulouse-Blagnac) were randomly selected participate study. Information...

10.1080/15402002.2017.1409224 article EN Behavioral Sleep Medicine 2017-11-27

The sexuality of people living with HIV (PLHIV) is a key issue in the fight against HIV, as it influences both dynamic epidemic and quality life PLHIV. present study examined factors associated cessation sexual relations after diagnosis among men women five countries: Mali, Morocco, Democratic Republic Congo, Romania Ecuador. A community-based cross-sectional was implemented by mixed consortium [researchers/community-based organizations (CBO)]. Trained CBO members interviewed 1500 PLHIV...

10.1080/09540121.2016.1146208 article EN cc-by-nc-nd AIDS Care 2016-02-28

Background Testicular germ cell tumors (TGCT) are the most frequent cancer in young men developed countries. Parental occupational exposures during early-life periods suspected to increase TGCT risk. The objective was estimate association between parental occupations at birth and adult TGCT. Methods A case–control study conducted, including 454 cases aged 18–45 from 20 French university hospitals, matched 670 controls based on region year of birth. Data collected participants included jobs...

10.3389/fpubh.2023.1303998 article EN cc-by Frontiers in Public Health 2024-01-16

Abstract Background Few studies have considered aircraft noise annoyance and sensitivity in analyses of the health effects noise, especially relation to medication use. This study aims investigate moderating mediating role these two factors relationship between levels use among 5860 residents ten European airports included HYENA DEBATS studies. Methods Information on annoyance, sensitivity, use, demographic, socio-economic lifestyle was collected during a face-to-face interview at home....

10.1186/s12889-021-10280-3 article EN cc-by BMC Public Health 2021-02-05

Previously focused primarily on enteric neurons, studies of the nervous system (ENS) in both health and disease are now broadening to recognize equally significant role played by glial cells (EGCs). Commensurate vast array gastrointestinal functions they influence, EGCs exhibit considerable diversity terms location, morphology, molecular profiles, functional attributes. However, mechanisms underlying this diversification remain largely unexplored. To begin unraveling mechanistic complexities...

10.3389/fnins.2024.1392703 article EN cc-by Frontiers in Neuroscience 2024-08-29

<h3>Introduction</h3> Testicular cancer is the most common in young men. The causes are largely unknown, although prenatal occupational and environmental exposures have been suggested. We investigated associations between paternal exposure to heavy metals welding fumes at birth risk of testicular germ cell tumors (TGCT) their sons. <h3>Material Methods</h3> Four hundred fifty-four cases 670 controls were included from TESTIS a French nationwide case-control study on TGCT. INTEROCC job matrix...

10.1136/oem-2023-epicoh.15 article EN Abstracts 2023-03-01
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