A5036852227- Renal cell carcinoma treatment
- Prostate Cancer Treatment and Research
- Cancer Immunotherapy and Biomarkers
- Testicular diseases and treatments
- Renal and related cancers
- Prostate Cancer Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- CAR-T cell therapy research
- Bladder and Urothelial Cancer Treatments
- Mathematical Biology Tumor Growth
- Sarcoma Diagnosis and Treatment
- Cancer Genomics and Diagnostics
- Multiple and Secondary Primary Cancers
- Urinary and Genital Oncology Studies
- Education and Islamic Studies
- Ethics in Clinical Research
- Pancreatic and Hepatic Oncology Research
- Urologic and reproductive health conditions
- Economic and Financial Impacts of Cancer
- Urological Disorders and Treatments
- Neutropenia and Cancer Infections
- Cancer Diagnosis and Treatment
- Acute Lymphoblastic Leukemia research
- Cancer survivorship and care
- Glioma Diagnosis and Treatment
Centre de Recherche en Cancérologie de Lyon
2021-2025
Centre Léon Bérard
2013-2024
Duke University
2023-2024
Clinical Research Institute
2023-2024
Hospices Civils de Lyon
2021
European Society for Paediatric Oncology
2020
Cancéropôle Lyon Auvergne-Rhône-Alpes
2018
Institut d’Hématologie et d’Oncologie Pédiatrique
2015-2017
Memorial Sloan Kettering Cancer Center
2015
Indiana University Bloomington
2015
Purpose To define characteristics, treatment response, and outcomes of men with brain metastases (BM) from germ cell tumors (GCT). Patients Methods Data 523 BM GCT were collected retrospectively 46 centers in 13 countries by using standardized questionnaires. Clinical features correlated overall survival (OS) as the primary end point. Results present at initial diagnosis 228 (group A) relapse 295 B). OS 3 years (3-year OS) was superior group A versus B (48% v 27%; P < .001). Multiple...
Complications are often poorly identified and managed in cancer survivors after treatment restoring their initial quality of life remains a challenge, particularly context unequal access to care nationwide. The PASCA “Parcours de Santé au cours du Cancer [in English: healthcare pathways with cancer]” feasibility study was conducted the Léon Bérard Comprehensive Center (Lyon, France) assess complications detection program, who have received intensive chemotherapy. An network physicians...
To determine whether conformity to standard recommendations of retroperitoneal lymph node dissection (RPLND) after chemotherapy for testicular and primary nonseminomatous germ cell tumours (NSGCT) completeness surgical excision have an effect on oncological outcome.This was a retrospective study patients with NSGCT, initial involvement RPLNs, treated between June 1992 December 2002 in one institution. We reviewed the clinical, histological charts 151 such who had RPLND first-line...
Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized (mRCT) presents challenges. The Trial Innovation Network (TIN), established 2016 partner with Clinical Translational Science Award (CTSA) Consortium of academic medical institutions implementation mRCTs, consists 3 Centers (TICs) 1 Recruitment Center (RIC). This unique partnership has aimed address...
Background Testicular germ cell tumors (TGCT) are the most frequent cancer in young men developed countries. Parental occupational exposures during early-life periods suspected to increase TGCT risk. The objective was estimate association between parental occupations at birth and adult TGCT. Methods A case–control study conducted, including 454 cases aged 18–45 from 20 French university hospitals, matched 670 controls based on region year of birth. Data collected participants included jobs...
Trabectedin was recently approved for patients failing doxorubicin, the standard treatment advanced/metastatic sarcoma. This retrospective study aimed to compare trabectedin efficacy between compassionate use in unselected and clinical trials. From May 1999 January 2006, 92 were treated at Centre Léon Bérard, either phase II studies or on a named patient basis. All cases retrospectively analyzed assess terms of response, progression-free, overall survival. The objective response rate 10%...
Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men developed countries and their incidence rate has doubled worldwide over past 40 years. Early life exposures to pesticides suspected increase TGCT risk. Our research aimed at estimating adult risk associated with parental domestic use of during early periods child development. Methods We conducted a case-control study 304 cases, aged 18–45 years old, recruited 20 French university hospitals, 274...
Only a few case reports and small series of patients with sarcoidosis or sarcoid-like reaction testicular germ cell tumors (GCT) have been reported in the literature. We performed retrospective study GCT managed at Centre Léon-Bérard, who presented granulomatosis.We computerized search to identify all male both diagnosis granuloma seen Léon-Bérard between 1992 2008.A total 13 were identified among 1,182 tumors. The median age was 25.5 years. Six had stage I disease, 2 IIb 5 III. Sarcoid-like...
Background: Non-seminomatous germ cell tumors (NSGCTs) represent a rare yet the most prevalent malignancy among young men. Bone metastases (BMs) are exceedingly uncommon in this neoplasm, and available data regarding initial disease presentation, survival outcomes, prognostic significance of BMs limited. Methods: We conducted retrospective analysis 40 NSGCT patients with treated between 2001 2021 our tertiary care center. The cohort was stratified into synchronous (n = 29) metachronous 11)...
To identify predictive factors of nivolumab sensitivity, peripheral blood NKs and regulatory T-cell (Treg) were evaluated in patients with metastatic renal cell carcinoma (mRCC) enrolled the REVOLUTION trial.