A5055759564- Sperm and Testicular Function
- Reproductive Biology and Fertility
- Reproductive Health and Technologies
- Hormonal and reproductive studies
- Testicular diseases and treatments
- Sexual Differentiation and Disorders
- Prenatal Screening and Diagnostics
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Renal and related cancers
- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- Assisted Reproductive Technology and Twin Pregnancy
- Prostate Cancer Treatment and Research
- Epigenetics and DNA Methylation
- Ovarian function and disorders
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Folate and B Vitamins Research
- Reproductive Health and Contraception
- Genetic Syndromes and Imprinting
- Genomic variations and chromosomal abnormalities
- Artistic and Creative Research
- Sexual function and dysfunction studies
- Biomarkers in Disease Mechanisms
- Hemophilia Treatment and Research
Hôpital Tenon
2014-2025
Centre de Recherche Saint-Antoine
2021-2025
Inserm
2022-2025
Sorbonne Université
2013-2024
Assistance Publique – Hôpitaux de Paris
2010-2024
Cecos
2012-2023
Sorbonne Paris Cité
2023
Sorbonne University Abu Dhabi
2023
RELX Group (Netherlands)
2014
Hôpital Jean-Verdier
2013
There has been a growing interest over the past few years in impact of male nutrition on fertility.Infertility linked to overweight or obesity, and conventional semen parameter values seem be altered case high body mass index (BMI).A studies assessing BMI sperm DNA integrity have published, but they did not lead strong consensus.Our objective was explore further relationship between BMI, through 3-year multicentre study.Three hundred thirty partners subfertile couples were included.Using...
Background Recent progress in the treatment of sickle cell disease, particular use hydroxyurea, has considerably modified prognosis this disease. Many more patients now reach reproductive age. The objective study was to assess potential impact hydroxyurea on semen patients.Design and Methods In retrospective multicenter study, we evaluated sperm parameters fertility 44 analyzed hydroxyurea.Results We report data from largest series so far analyses with disease: 108 samples were analyzed,...
Abstract: Testicular cancer is the most common in young men. Several studies have reported an alteration semen quality nonseminoma tumors, but this result has not been confirmed all of published data. We performed a retrospective study population 1158 men with testicular who banked sperm between 1999 and 2003 11 French Centre d'Etude et de Conservation des Oeufs du Sperme humain laboratories. Our evaluated prefreeze postthaw parameters according to patient medical history, tumor histological...
BACKGROUND: Sperm donors represent an appropriate population for evaluating the frequency of chromosomal abnormalities in phenotypically normal and fertile adult males. METHODS: A large multicentric retrospective study was made within French CECOS (Centre d'Etude et de Conservation des ufs du Sperme) collecting cytogenetic, biological familial data sperm over a 25-year period. RESULTS: As whole, 10 202 karyotypes have been recorded. Thirty-eight karyotype aberrations (0.37%) diagnosed...
In elongating spermatids, human sperm chromatin undergoes a complex compaction in which the transition proteins are extensively replaced by protamine proteins. Several studies demonstrate that expression of is altered some men with male infertility. For this study, we screened PRM1 (protamine 1) gene for mutations large cohort 281 seeking infertility treatment. We identified c.102G > T transversion results an p.Arg34Ser amino acid change two men. One these patients presented oligozoospermia...
Abstract Background Sickle cell disease (SCD) is a prevalent hereditary disorder with significant morbidity, including potential impacts on male fertility. This study aims to evaluate the semen parameters in men SCD and assess outcomes of fertility preservation strategies. Methods retrospective included 121 referred Centre at Tenon University Hospital, Paris, between 2012 2023. Patients were categorized into three groups based hydroxyurea (HU) exposure: without HU (WHU), ongoing HU(OHU),...
The metabolic pathway of folate is thought to influence DNA stability either by inducing single/double stranded breaks or producing low levels S-adenosyl-methionine leading abnormal gene expression and chromosome segregation. Polymorphisms in the genes encoding enzymes metabolism show distinct geographic and/or ethnic variations some cases have been linked disease. Notably, Methylenetetrahydrofolate reductase (MTHFR) which homozygous (TT) state polymorphism c.665C>T (p.A222V) associated with...
In couples who have chosen and confirmed the fate of surplus frozen embryos, which factors influence their decision, with a special emphasis on symbolic representation embryo(s)? Embryo gamete donation use significantly cryopreserved embryos. Previous studies report difficulties for to decide whether or not continue storing embryo(s) different been already highlighted including embryo conceptualization, information support provided by medical institution, quality life events. Little is...
Testicular sperm extraction (TESE) is an essential therapeutic tool for the management of male infertility. However, it invasive procedure with a success rate up to 50%. To date, no model based on clinical and laboratory parameters sufficiently powerful accurately predict retrieval in TESE. The aim this study compare wide range predictive models under similar conditions TESE outcomes patients nonobstructive azoospermia (NOA) identify correct mathematical approach apply, most appropriate...
Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men developed countries and their incidence rate has doubled worldwide over past 40 years. Early life exposures to pesticides suspected increase TGCT risk. Our research aimed at estimating adult risk associated with parental domestic use of during early periods child development. Methods We conducted a case-control study 304 cases, aged 18–45 years old, recruited 20 French university hospitals, 274...