A5013926262- Reproductive Health and Technologies
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- LGBTQ Health, Identity, and Policy
- Assisted Reproductive Technology and Twin Pregnancy
- Ovarian function and disorders
- Renal and related cancers
- Prenatal Screening and Diagnostics
- Sexuality, Behavior, and Technology
- Family Dynamics and Relationships
- Sexual Differentiation and Disorders
- Testicular diseases and treatments
- Social Policies and Family
- Hormonal and reproductive studies
- Child Welfare and Adoption
- Cancer, Lipids, and Metabolism
- Psychoanalysis and Psychopathology Research
- Cholesterol and Lipid Metabolism
- Hemoglobinopathies and Related Disorders
- Cystic Fibrosis Research Advances
- Chromosomal and Genetic Variations
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Pesticide and Herbicide Environmental Studies
- Steroid Chemistry and Biochemistry
- Mitochondrial Function and Pathology
Université Paris Cité
2020-2025
Assistance Publique – Hôpitaux de Paris
2018-2025
Hôpital Cochin
2018-2025
Cecos
2021
Maternité Port Royal
2018-2020
Pitié-Salpêtrière Hospital
2020
Sorbonne Université
2020
CHU Dijon Bourgogne
2003-2016
Aarhus University Hospital
2013
Inserm
2003
The preservation of fertility is an integral part care children requiring gonadotoxic treatments for cancer or non-malignant diseases. In France, the cryopreservation ovarian tissue has been considered and offered as a clinical treatment since its inception. aim this study to review 20 years activity in by (OTC) feasibility oocyte isolation from at single center. Retrospective including patients aged 15 younger who underwent OTC, combined some with isolated oocytes, before highly malignant...
How efficacious is transplantation of ovarian cortex previously exposed to chemotherapy? Prior exposure chemotherapy did not disrupt the function cryopreserved tissue after transplantation. Ovarian cryopreservation (OTC) followed by (OTT) an technique for restoration female fertility. At least 130 children have been born following this procedure. To date, little known about efficacy OTT in patients cancer prior OTC. This study evaluates recovery and fertility 31 consecutive who had received...
Thus far, liver, intestine, heart, and placenta have been shown to secrete apolipoprotein (apo)B-containing lipoproteins. In the present study, we first investigated lipoproteins in human follicular fluid (FF), surrounding developing oocytes within ovary, as well corresponding plasma samples (n = 12). HDL cholesterol FF correlated with (r 0.80, P < 0.01), whereas VLDL did not, indicating that might originate directly from granulosa cells producing FF. Primary expressed apoB, microsomal...
Progesterone production by luteal cells is dependent on the supply of cholesterol lipoproteins. The aim this study was to determine whether liver X receptors (LXRs) contribute homeostasis and progesterone secretion in human luteinized granulosa cells. Cells were isolated from follicular aspirates patients undergoing vitro fertilization. Luteinization induced a 7-day treatment with chorionic gonadotrophin. LXR beta expressed at higher levels than alpha its expression increased during...
The high frequency of the cystic fibrosis (CF) transmembrane conductance regulator (CFTR) gene mutation p.Arg117His in patients with congenital bilateral absence vas deferens (CBAVD) and newborns screened for CF has created a dilemma.Phenotypic genotypic data were retrospectively collected 179 non-newborn French individuals carrying second CFTR referred symptoms or family history, by all molecular genetics laboratories, referring physicians, care centres infertility clinics.97% had intronic...
Follicular fluid (FF) is an important micro-environment influencing oocyte growth, its development competence, and embryo viability. The FF content analysis allows to identify new relevant biomarkers, which could be predictive of in vitro fertilization (IVF) outcomes. Inside ovarian follicle, the amount components from granulosa cells (GC) secretion, regulated by gonadotropins, play a major role follicle development. This prospective study included 61 female undergoing IVF or...
Abstract Background Testicular germ cell tumours (TGCT) are the most frequent cancers in young men developed countries and their incidence rate has doubled worldwide over past 40 years. Early life exposures to pesticides suspected increase TGCT risk. Our research aimed at estimating adult risk associated with parental domestic use of during early periods child development. Methods We conducted a case-control study 304 cases, aged 18–45 years old, recruited 20 French university hospitals, 274...
Many studies reported that reproductive desire could be high among transgender individuals. In France, fertility preservation and sperm donation were very little proposed to individuals until recently, mainly because the Bioethics Law allows use of assisted technologies only in infertile couples prohibits surrogacy. To evaluate distribution care on French territory concerning A multicentric national survey was carried out between January 2019 October 2020 28 technology centres CECOS (Centres...
Medical advances in assisted reproductive technology have created new ways for transgender persons to become parents outside the context of adoption. The limited empirical data does not support idea that trans-parenthood negatively impacts children’s development. However, question has led lively societal debates making need evidence-based studies urgent. We aimed compare cognitive development, mental health, gender identity, quality life and family dynamics using standardized instruments...
de documents scientifiques niveau recherche, publiés ou non, émanant des établissements d'enseignement et recherche français étrangers, laboratoires publics privés.
Today, individuals and couples with fertility issues can use advances in biomedical technologies to conceive. Transgender persons also benefit from these not only actualize their self-identified gender identities but experience parenthood. These strategies for self-actualize access parenthood have improved the condition of transgender persons. However, some may question welfare offspring because such transfamily forms are often confusing many. The sparse research on psychological well-being...
The purpose of the present multicenter study was to investigate whether an artificial insemination with donor sperm (AID) procedure after intra-couple intracytoplasmic injection (ICSI) failure offers a significant chance pregnancy and identify prognostic factors for AID procedure. An eleven-year retrospective conducted among 13 Centre d'Etude et de Conservation des Oeufs du Sperme (CECOS) centers. A total 319 couples having undergone intra-conjugal ICSI were included in this study; 1,159...
Germline mosaicism is considered to be a rare event. However, its occurrence underestimated due the limited availability of germ cells. The genomic variations that underlie this phenomenon comprise single nucleotide polymorphism (SNPs), copy number (CNVs) and aneuploidies. In case CNVs, deletions are more frequent in paternal germline while duplications commonly maternal origin. increases with age as risk SNPs increase cell divisions. We here report spermatozoa donor resulted one...
Abstract Background Spinal cord injury often results in erectile dysfunction and an ejaculation along with impaired semen parameters. Fertility is a major concern spinal adult males some fear that the delay post‐spinal may negatively affect sperm quality. Objectives We aimed to (i) assess parameters over time SCI patients according age at injury, level completeness (ii) measure markers for inflammation marker of oxidative stress investigate their impact on Materials Methods The study...
More than half of transgender (TG) men wish to have children. Until recently, TG people in France were rarely offered gamete donation, mainly because the Bioethics Law allows use assisted reproductive technologies (ART) only infertile couples. The option currently available for heterosexual couples with a man is ART sperm donation. Center Study and Preservation Eggs Sperm (CECOS) Cochin Hospital first French center propose donation such couples, has done so since 1999.To determine main...