A5015027329- Ethics in Clinical Research
- Hormonal Regulation and Hypertension
- Health Policy Implementation Science
- Health Literacy and Information Accessibility
- Social Media in Health Education
- Renin-Angiotensin System Studies
- Biomedical Ethics and Regulation
- Health and Medical Research Impacts
- Chromosomal and Genetic Variations
- Misinformation and Its Impacts
- Ion Transport and Channel Regulation
- Pharmacogenetics and Drug Metabolism
- Sodium Intake and Health
- Birth, Development, and Health
- Thyroid Disorders and Treatments
- Meta-analysis and systematic reviews
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Mental Health and Patient Involvement
- Telemedicine and Telehealth Implementation
- Mobile Health and mHealth Applications
- Diabetes Treatment and Management
- Evaluation and Performance Assessment
- Artificial Intelligence in Healthcare and Education
- Inflammatory mediators and NSAID effects
- Patient-Provider Communication in Healthcare
Vanderbilt University Medical Center
2020-2024
Vanderbilt University
2007-2020
University of Vermont
2010
Boston University
2004
Boston Public Schools
2004
Dipeptidyl peptidase-IV inhibitors improve glucose homeostasis in type 2 diabetics by inhibiting degradation of the incretin hormones. inhibition also prevents breakdown vasoconstrictor neuropeptide Y and, when angiotensin-converting enzyme (ACE) is inhibited, substance P. This study tested hypothesis that dipeptidyl would enhance blood pressure response to acute ACE inhibition. Subjects with metabolic syndrome were treated 0 mg enalapril (n=9), 5 (n=8), or 10 (n=7) after treatment...
Early-generation β-blockers lower blood pressure and reduce cardiovascular morality in coronary artery disease congestive heart failure but worsen glucose homeostasis fibrinolytic balance. Nebivolol is a third-generation β-blocker that increases the bioavailability of nitric oxide. We compared effect nebivolol (5 mg/d) β(1)-selective antagonist metoprolol (100 on markers fibrinolysis 46 subjects with metabolic syndrome. Subjects underwent frequently sampled IV tolerance test after 3-week...
New technologies and disruptions related to Coronavirus disease-2019 have led expansion of decentralized approaches clinical trials. Remote tools methods hold promise for increasing trial efficiency reducing burdens barriers by facilitating participation outside traditional settings taking studies directly participants. The Trial Innovation Network, established in 2016 the National Center Advancing Clinical Translational Science address critical roadblocks research accelerate translational...
Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized (mRCT) presents challenges. The Trial Innovation Network (TIN), established 2016 partner with Clinical Translational Science Award (CTSA) Consortium of academic medical institutions implementation mRCTs, consists 3 Centers (TICs) 1 Recruitment Center (RIC). This unique partnership has aimed address...
Clinical trials continue to face significant challenges in participant recruitment and retention. The Recruitment Innovation Center (RIC), part of the Trial Network (TIN), has been funded by National for Advancing Translational Sciences Institutes Health develop innovative strategies technologies enhance engagement all stages multicenter clinical trials. In collaboration with investigator teams liaisons at Science Award institutions, RIC is charged mission design, field-test, refine novel...
Interruption of the renin-angiotensin-aldosterone system prevents incident diabetes in high-risk individuals, although mechanism remains unclear. To test hypothesis that activation endogenous or exogenous aldosterone impairs insulin secretion humans. We conducted a randomized, blinded crossover study vs vehicle and compared effects low-sodium versus high-sodium diet. Academic clinical research center. Healthy, nondiabetic, normotensive volunteers. Infusion (0.7 μg/kg/h for 12.5 h) during low...
Abstract Introduction: Lack of participation in clinical trials (CTs) is a major barrier for the evaluation new pharmaceuticals and devices. Here we report results analysis dataset from ResearchMatch, an online registry, using supervised machine learning approaches deep approach to discover characteristics individuals more likely show interest participating CTs. Methods: We trained six classifiers (Logistic Regression (LR), Decision Tree (DT), Gaussian Naïve Bayes (GNB), K-Nearest Neighbor...
Abstract Introduction: Clinical trial participation among US Hispanics remains low, despite a significant effort by research institutions nationwide. ResearchMatch, national online platform, has matched 113,372 individuals interested in participating with studies conducted 8778 researchers. To increase accessibility to Spanish speakers, we translated the ResearchMatch platform into implementing tenets of health literacy and respecting linguistic cultural diversity across Hispanic population....
Defects in the handling of renal salt reabsorption may contribute to interindividual differences blood-pressure regulation and susceptibility hypertension. Sodium chloride thick ascending limb (TAL) is dependent part on channel, ClC-Kb (encoded by CLCNKB), its accessory subunit, barttin BSND). We investigated genetic variations BSND a screening population, genotyped homogenous cohort normotensive hypertensive Ghanaian subjects, addition four ethnically defined control populations. Functional...
Obtaining complete and accurate information in recruitment registries is essential for matching potential participants to research studies which they qualify. Since electronic health record (EHR) systems are required make patient data available external systems, an interface between EHRs may improve accuracy completeness of volunteers' profiles. We tested this hypothesis on ResearchMatch (RM), a disease- institution-neutral registry with 1357 across 255 institutions.We developed where...
Abstract Involving participants in the design of clinical trials should improve overall success a study. For this to occur, streamlined mechanisms are needed connect populations potentially impacted by given study or health topic with research teams order inform trial meaningful and timely manner. To address need, we developed an innovative mechanism called “ResearchMatch Expert Advice Tool” that quickly obtains volunteer perspectives from specific conditions lived experiences using national...
Renin-angiotensin-aldosterone system blockade reduces the incidence of type 2 diabetes in clinical trials. We previously demonstrated that aldosterone impairs insulin secretion via a direct beta-cell effect mice. To test hypothesis and mineralocorticoid receptor contribute to impaired humans, we enrolled subjects with metabolic syndrome treated hydrochlorothiazide (HCTZ) 12.5 mg daily for 4 weeks (baseline) followed by either Spironolactone 25 (SPL, n=16) versus Aliskiren 150 (ALI, n=19)...
Renin-angiotensin-aldosterone system (RAAS) activation worsens insulin resistance, and aldosterone impairs secretion via a direct beta-cell effect in mice. To test the hypothesis that endogenous RAAS contributes to impaired glucose tolerance humans, we assessed homeostasis 37 subjects with metabolic syndrome (18 Female; 29 white/7 African American; age 45.6±1.8 years). After washout of anti-hypertensive medications, was characterized as normal (NGT, n=21), (IGT, n=11), or type 2 diabetes...
OBJECTIVES/GOALS: Innovations with positive health impact are a high priority for NCATS and CTSAs. Program design that uses the Causal Pathway approach incorporates performance indicators assess impact. We applied thinking to an ongoing national program enhance evaluation of report Lessons Learned. METHODS/STUDY POPULATION: conducted day-long onsite workshop introduce model project team, build capacity, map existing elements Logic Models representing Specific Aims. A local (CP) champion was...
Abstract Introduction: The process of identifying and connecting with clinical trial study teams can be challenging difficult for members the public. national volunteer community registry, ResearchMatch, public trials search tool, Trials Today, work in tandem to bridge this connection by providing a streamlined potential participants identify which may interest. Methods: Building on existing infrastructure ResearchMatch we created mechanism request that their basic contact information (e.g.,...