A5058067950- Vaccine Coverage and Hesitancy
- Health and Medical Research Impacts
- Hepatitis B Virus Studies
- Ethics in Clinical Research
- Pneumonia and Respiratory Infections
- Meta-analysis and systematic reviews
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Health Systems, Economic Evaluations, Quality of Life
- Intracerebral and Subarachnoid Hemorrhage Research
- Healthcare Policy and Management
- Influenza Virus Research Studies
- Pharmaceutical Economics and Policy
- Statistical Methods in Clinical Trials
- Respiratory viral infections research
- Neurosurgical Procedures and Complications
- Patient Satisfaction in Healthcare
- Biotechnology and Related Fields
- Viral Infections and Outbreaks Research
- Traumatic Brain Injury and Neurovascular Disturbances
Johns Hopkins Medicine
2023-2024
Johns Hopkins University
2010-2024
Aeras
2012-2017
University of Baltimore
2010
Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized (mRCT) presents challenges. The Trial Innovation Network (TIN), established 2016 partner with Clinical Translational Science Award (CTSA) Consortium of academic medical institutions implementation mRCTs, consists 3 Centers (TICs) 1 Recruitment Center (RIC). This unique partnership has aimed address...
Rapid uptake of new vaccines can improve health and wealth contribute to meeting Millennium Development Goals. In the past, however, introduction use has been characterized by delayed in countries where need is greatest. Based on experience with accelerating adoption Hib, pneumococcal rotavirus vaccines, we propose here a framework for vaccine that may be useful future efforts. The organizes major steps process into continuum from evidence policy, implementation finally access. It highlights...
Abstract Patients with acute spontaneous intracerebral hemorrhage (ICH) develop secondary neuroinflammation and cerebral edema that can further damage the brain lead to increased risk of neurologic complications. Preclinical studies in animal models injury have shown a novel small-molecule drug candidate, MW01-6-189WH (MW189), decreases improves functional outcomes. MW189 was also safe well tolerated phase 1 healthy adults. The proof-of-concept 2a Biomarker Edema Attenuation IntraCerebral...
One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects planning and execution. The multicenter model can provide potential a more environment, but it also place at risk becoming uninformative due to lack rigor, quality control, or effective recruitment, resulting in premature discontinuation and/or non-publication. Key factors support informativeness having right team resources during study implementation adequate...
Abstract Improving the quality and conduct of multi-center clinical trials is essential to generation generalizable knowledge about safety efficacy healthcare treatments. Despite significant effort expense, many are unsuccessful. The National Center for Advancing Translational Science launched Trial Innovation Network address critical roadblocks in by leveraging existing infrastructure developing operational innovations. We provide an overview that led opportunities innovation, our work...