A5103148574- Herpesvirus Infections and Treatments
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Vibrio bacteria research studies
- Acne and Rosacea Treatments and Effects
- Ultrasound and Hyperthermia Applications
- Hepatitis Viruses Studies and Epidemiology
- Hepatitis B Virus Studies
- Vaccine Coverage and Hesitancy
- Ultrasound and Cavitation Phenomena
- Healthcare and Venom Research
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Malaria Research and Control
- Antibiotic Resistance in Bacteria
- Child Nutrition and Water Access
- Photoacoustic and Ultrasonic Imaging
- Ultrasound Imaging and Elastography
- Vector-borne infectious diseases
- Bartonella species infections research
- Pneumonia and Respiratory Infections
- Virology and Viral Diseases
- COVID-19 epidemiological studies
- Nerve injury and regeneration
- Antimicrobial Resistance in Staphylococcus
University of Miami
2020-2025
Weill Cornell Medicine
2024
Cornell University
2024
Merck & Co., Inc., Rahway, NJ, USA (United States)
2013-2023
Universidad Libre de Colombia
2023
Takeda (United States)
2021-2022
Jackson Memorial Hospital
2020-2021
Columbia University
2014-2019
Universidade Federal de São Paulo
2018
United States Military Academy
2012-2016
For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects continued existence ubiquitous haplotypes over millennia. In contrast, clinical use fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion haplotype H58 in Asia Africa. Yet, antibiotic-sensitive strains other than still persist despite selection for...
Malaria remains the most important parasitic cause of mortality in humans. Its presentation is thought to vary according intensity Plasmodium falciparum transmission. However, detailed descriptions presenting features and risk factors for death are only available from moderate transmission settings. Such help improve case management identify priority research areas. Standardized systematic procedures were used collect clinical laboratory data on 6,624 children admitted hospital over a 1-year...
This study describes the pattern and extent of drug resistance in 1,774 strains Salmonella enterica serovar Typhi isolated across Asia between 1993 2005 characterizes molecular mechanisms underlying reduced susceptibilities to fluoroquinolones these strains. For 1,393 collected southern Vietnam, proportion multidrug has remained high since (50% 2004) there was a dramatic increase nalidixic acid (4%) (97%). In cross-sectional sample 381 from 8 Asian countries, Bangladesh, China, India,...
Typhoid fever remains an important cause of illness and death in the developing world. Uncertainties about protective effect Vi polysaccharide vaccine children under age 5 years vaccine's programmatic conditions have inhibited its use countries.
Abstract Little is known about the causes of enteric fever in Asia. Most cases are believed to be caused by Salmonella enterica serovar Typhi and remainder S. Paratyphi A. We compared their incidences using standardized methods from population-based studies China, Indonesia, India, Pakistan.
Purpose Ultrasound neuromodulation is a promising noninvasive technique for controlling neural activity. Previous small animal studies suffered from low targeting specificity because of the ultrasound frequencies (<690 kHz) used. In this study, authors demonstrated capability focused (FUS) in megahertz‐range to achieve superior murine brain as well demonstrate modulation both motor and sensory responses. Methods FUS sonications were carried out at 1.9 MHz with 50% duty cycle, pulse...
Herpes zoster (HZ), also known as shingles, is a painful and commonly occurring condition in the United States. In spite of universally recommended vaccine for use immunocompetent adults aged 60 years older, HZ continues to impact American public, better understanding its current incidence needed. The objective study estimate overall age- gender-specific rates (IRs) among an US population 2011 following availability vaccine.Claims data from Truven Health MarketScan® Research databases...
Cavitation events seeded by microbubbles have been previously reported to be associated with MR- or fluorescent-contrast enhancement after focused ultrasound (FUS)-induced blood-brain barrier (BBB) opening. However, it is still unknown whether bubble activity can correlated the reversibility (the duration of opening and likelihood safe reinstatement) permeability opened BBB, which critical for clinical translation using passive cavitation detection monitor, predict control In this study,...
The blood—brain barrier (BBB) constitutes a major obstacle in brain drug delivery. Focused ultrasound (FUS) conjunction with microbubbles has been shown to open the BBB noninvasively, locally, and transiently allow large molecules diffusion. Neurturin (NTN), member of glial-derived neurotrophic factor (GDNF) family, demonstrated have neuroprotective regenerative effects on dopaminergic neurons vivo using invasive delivery methods. brain's ascending nigrostriatal pathway is severely damaged...
Background: Pneumococcal disease remains a public health priority in adults. Safety and immunogenicity of 2 different formulations 15-valent pneumococcal conjugate vaccine (PCV15) containing 13 serotypes included 13-valent (PCV13) plus additional (22F 33F) were evaluated adults ≥ 50 years (V114-006; NCT02547649).Methods: A total 690 subjects (230/arm) received single dose either PCV15 Formulation A, B, or PCV13 followed for safety 14 days postvaccination. Serotype-specific opsonophagocytic...
There is the need to properly characterize temporal trend of U.S. Staphylococcus aureus infections, including methicillin-resistant S. (MRSA) and community-acquired (CA) MRSA in inpatient outpatient settings.The study used Surveillance Network(®) surveillance database (Eurofins Medinet) National Hospitalization Discharge Survey for period 1998-2007. CA-MRSA phenotype was defined by a resistance profile that includes susceptibility gentamicin cotrimoxazole, coresistance...
ObjectivesThe most common complication of herpes zoster (HZ) is postherpetic neuralgia (PHN), a persistent pain that can substantially affect quality life (QoL). This analysis aimed to evaluate predictors PHN in HZ patients.MethodsA pooled prospective cohort studies patients aged ≥50 years from North America (Canada), Latin (Brazil, Mexico, and Argentina), Asia (Taiwan, South Korea, Thailand) was performed. Patients within 14 days rash onset were included. The incidence defined as worst...
Abstract The objective of this study was to unveil the potential mechanism focused ultrasound (FUS)-enhanced intranasal (IN) brain drug delivery and assess its feasibility in therapeutic molecules. Delivery outcomes fluorescently-labeled dextrans mouse brains by IN administration either before or after FUS sonication were compared evaluate whether enhances active pumping passive diffusion. Fluorescence imaging slices found that followed achieved significantly higher than only, while...
Hepatitis B and C markers were tested in 980 pregnant women, the infants born to infected mothers, a random sample of 42 50, respectively, children uninfected mothers Tanzania. Sixty-two women (6.3%) positive for HBsAg 15 (24%) HBeAg-seropositive. Anti-HCV was detected 49 (5%), (31%) whom had detectable viremia. HCV RNA serum levels low only genotype 4 identified. Sixty-six (6.7%) anti-HIV, six coinfected with HBV one HCV. Anti-HEV negative 180 tested. At 8 months age, 8% 2% HBV-infected...
Recent research has indicated that the malaria burden in Asia may have been vastly underestimated. We conducted a prospective community-based study an impoverished urban site Kolkata, India, to estimate of and typhoid fever identify risk factors for these diseases. In population 60452 people, 3605 episodes were detected over 12-month period. The blood films 93 febrile patients contained Plasmodium (90 P. vivax, 2 falciparum 1 malariae). Blood cultures from 95 grew Salmonella enterica...
Exposure of the individual to contaminated food or water correlates closely with risk for enteric fever. Since public health interventions such as improvement vaccination campaigns are implemented groups individuals we were interested whether factors not only but households, neighbourhoods and larger areas can be recognised?We conducted a large fever surveillance study analyzed which correlate on an level associated high low incidence. Individual data linked population based geographic...