A5010130353- Streptococcal Infections and Treatments
- Escherichia coli research studies
- Parasitic Infections and Diagnostics
- Amoebic Infections and Treatments
- Vibrio bacteria research studies
- Viral gastroenteritis research and epidemiology
- Salmonella and Campylobacter epidemiology
- Inflammasome and immune disorders
- Pancreatitis Pathology and Treatment
- Malaria Research and Control
- Vaccine Coverage and Hesitancy
- SARS-CoV-2 and COVID-19 Research
- Clostridium difficile and Clostridium perfringens research
- COVID-19 Clinical Research Studies
- Antimicrobial Resistance in Staphylococcus
- Vitamin C and Antioxidants Research
- Research on Leishmaniasis Studies
- Tuberculosis Research and Epidemiology
- Mosquito-borne diseases and control
- Probiotics and Fermented Foods
- Global Public Health Policies and Epidemiology
- Drug Transport and Resistance Mechanisms
- Leprosy Research and Treatment
- Child Nutrition and Water Access
- Amyotrophic Lateral Sclerosis Research
Department of Biotechnology
2013-2025
Sir Ganga Ram Hospital
2016-2025
Institute of Liver and Biliary Sciences
2014-2025
Artemis Hospitals
2023-2024
Indian Council of Medical Research
2011-2023
Manav Rachna International Institute of Research and Studies
2023
Jawaharlal Nehru University
2017-2021
National Institute of Immunology
2009-2021
Translational Health Science and Technology Institute
2012-2021
Apollo Hospitals
2019-2021
Visceral leishmaniasis (VL) is a major public health problem in Bihar, accounting for 90% of all cases India. Development high levels resistance to various existing drugs necessitated the search alternative orally administered drugs. Hospital-based studies have shown that oral miltefosine highly effective treatment VL both adults and children.An open, single-arm trial was designed investigate feasibility patients with field conditions 13 centers Bihar.The phase 4 study conducted among 1132...
Typhoid fever remains an important cause of illness and death in the developing world. Uncertainties about protective effect Vi polysaccharide vaccine children under age 5 years vaccine's programmatic conditions have inhibited its use countries.
Gross inequities in disease burden between developed and developing countries are now the subject of intense global attention. Public private donors have marshaled resources created organizational structures to accelerate development new health products procure distribute drugs vaccines for poor. Despite these encouraging efforts directed primarily from funded by industrialized countries, sufficiency sustainability remain enormous challenges because sheer magnitude problem. Here we highlight...
A new collaborative model of research is needed to increase resources, prioritize the R (ii) pace, reduce overlap, and more systematically explore elements delivery systems for vaccines; (iii) use common standards prompt comparative testing vaccine candidates; (iv) expand resources manufacturing candidates speed their in human trials; (v) capacity international clinical trials focus this effort toward quickly measuring effectiveness protection as prototype are identified.
Background Killed oral cholera vaccines (OCVs) have been licensed for use in developing countries, but protection conferred by OCVs beyond two years of follow-up has not demonstrated randomized, clinical trials. Methods/Principal Findings We conducted a cluster-randomized, placebo-controlled trial two-dose regimen low-cost killed whole cell OCV residents 1 year age and older living 3,933 clusters Kolkata, India. The primary endpoint was culture-proven Vibrio cholerae O1 diarrhea episodes...
Although India is a leading producer and exporter of vaccines, the country home to one-third world's unimmunized children. Fewer than 44 percent India's young children receive full schedule immunizations. vaccine deficit has several causes: little investment by government; focus on polio eradication at expense other immunizations; low demand as consequence poorly educated population presence anti-vaccine advocates. In this article we describe recommend that government move quickly increase...
Background Even though cholera has existed for centuries and many parts of the country have sporadic, endemic epidemic cholera, it is still an under-recognized health problem in India. A Cholera Expert Group was established to gather evidence prepare a road map control This paper identifies burden hotspots factors associated with increased risk disease. Methodology/Principle findings We acquired district level data on case reports 2010–2015 from Integrated Disease Surveillance Program....
Negative-strand RNA viruses form cytoplasmic inclusion bodies (IBs) representing virus replication foci through phase separation or biomolecular condensation of viral and cellular proteins, as a hallmark their infection. Alternatively, mammalian cells stalled mRNA containing antiviral stress granules (SGs), consequence phosphorylation eukaryotic initiation factor 2α (eIF2α) several RNA-binding proteins including TIA-1. Whether how Chandipura (CHPV), an emerging human pathogen causing...
The most important immunopathological consequence of infection with Leishmania seen in murine and human hosts is the suppression T cell-mediated immune responses to both mitogens leishmanial antigens. It has been suggested that this mediated by macrophages, either defective antigen processing presentation or elaboration suppressive mediators like prostaglandins. Optimum activation helper cells requires not only cell receptor occupancy antigen-Ia complex, but also costimulatory signals...
Abstract The most important immunopathological consequence of experimental mycobacterial infection is the suppression T cell‐mediated immune response to both mitogens and antigens. We registered that there was decreased concanavalin A‐induced spleen cell proliferation in infected susceptible BALB/c mice as compared normal mice. In resistant (C3H/HeJ) mice, with bacteria did not induce any mitogen‐induced lymphoproliferation. Likewise, delayed‐type hypersensitivity (DTH) responses, keyhole...