A5013762254- Cell Adhesion Molecules Research
- T-cell and B-cell Immunology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Monoclonal and Polyclonal Antibodies Research
- HIV/AIDS Impact and Responses
- Global Public Health Policies and Epidemiology
- Vaccine Coverage and Hesitancy
- Immune Response and Inflammation
- Galectins and Cancer Biology
- Health Systems, Economic Evaluations, Quality of Life
- Global Maternal and Child Health
- Biotechnology and Related Fields
- HIV Research and Treatment
- Global Health and Surgery
- Higher Education Governance and Development
- Celiac Disease Research and Management
- SARS-CoV-2 and COVID-19 Research
- Hepatitis B Virus Studies
- Diabetes and associated disorders
- Community Development and Social Impact
- Global Educational Policies and Reforms
- Intellectual Property and Patents
- African cultural and philosophical studies
- Amoebic Infections and Treatments
University of KwaZulu-Natal
2003-2014
South African Medical Research Council
1999-2002
Hammersmith Hospital
1989-1993
University of Ulster
1992
London Postgraduate Medical and Dental Education
1992
Royal Victoria Hospital
1992
St Thomas' Hospital
1991
Stockholm University
1990
National Institutes of Health
1988-1989
Harvard University
1988
Abstract Studies of cell-surface molecules involved in human T cell interaction reveal that differential expression each three adhesion (LFA-3, CD2, and LFA-1) subdivides peripheral blood cells into major subpopulations. Systematic analysis the relationship between these other markers subsets demonstrates a single subset lymphocytes distinguished by enhanced LFA-3, LFA-1, (CDw29 [4B4], UCHL1, Pgp-1). Large differences relative are observed for UCHL1 (29-fold) LFA-3 (greater than 8-fold),...
No AccessStand Alone Books1 Feb 2013Disease and Mortality in Sub-Saharan AfricaSecond EditionAuthors/Editors: Eduard R. Bos, Dean T. Jamison, Florence Bainga, Richard G. A. Feacham, Malegapuru Makgoba, Karen J. Hofman, hama O. RogoEduard Rogohttps://doi.org/10.1596/978-0-8213-6397-3SectionsAboutPDF (5.1 MB) ToolsAdd to favoritesDownload CitationsTrack Citations ShareFacebookTwitterLinked In Abstract:Current data trends morbidity mortality for the sub-Saharan Region as presented this new...
Although intercellular adhesion molecule-1 (ICAM-1) has been implicated as a ligand in some LFA-1-dependent adhesion, its importance to T cell function not established. The present studies investigate the of ICAM-1 for human cytotoxic lymphocytes (CTL), both their formation antigen-independent conjugates (AIC) and lysis targets. Analysis monoclonal antibody (mAb) inhibition AIC indicate that mAb 1 blocks (a) with but all targets; (b) LFA-1 pathway CD2/LFA-3 adhesion; (c) by binding target...
A new collaborative model of research is needed to increase resources, prioritize the R (ii) pace, reduce overlap, and more systematically explore elements delivery systems for vaccines; (iii) use common standards prompt comparative testing vaccine candidates; (iv) expand resources manufacturing candidates speed their in human trials; (v) capacity international clinical trials focus this effort toward quickly measuring effectiveness protection as prototype are identified.
We used our previously defined ‘Equity Index’ to determine the demographic profile of 23 universities in South Africa’s higher education sector. undertook an analysis profiles both students and staff based on audited 2011 data from Higher Education Management Information System. also considered equity-weighted research index. show general applicability Euclidean formula calculating 230 equity indices within university All institutions country were ranked these categories. These rankings are...
Abstract We have tested the potential role of thyroid cell intercellular adhesion molecule‐1 (ICAM‐1) expression by in vitro assays clustering and cytotoxicity. Increased ICAM‐1 appeared within 24 h stimulation with cytokines was not inhibited antithyroid drug methimazole. Autologous allogeneic lymphocyte‐thyroid cluster formation, assessed flow cytometry, reduced about one‐third presence a monoclonal antibody against ICAM‐1, regardless whether cells were expressing basal levels or had been...
Summary The expression of intercellular adhesion molecule-l (ICAM-1) was studied on peroral jejunal biopsies from patients with coeliac disease. untreated exhibited greater staining the superficial lamina propria cells compared treated and controls. A gluten challenge in produced an altered pattern within 2 h. results demonstrate role ICAM-1 disease, providing further evidence for pathogenesis this condition.
Developed industrial nations are not taking their research and development colleagues of the developing world as equal partners in fighting infectious disease.
South Africans live in one of the most unequal societies world where squalor and abject poverty side by with abundant wealth. The challenge inequality is captured eloquently National Development Plan (NDP), government’s roadmap African economic future. It has become obvious that new generation student leadership Africa unleashed a unique opportunity to overhaul transform higher education system fundamentally. They are tired current hangs on pillars racism white supremacy continues reproduce...
Three fifteen‐amino‐acid polypeptides designated peptides 1, 2 and 3 were synthesised as likely candidates for mimicking the role of ICAM‐2 a ligand. The ability each peptide to bind lymphoid cells was tested. Peptide largely mediated cell attachment unstimulated this binding only marginally increased by stimulating with phorbol dibutyrate (P(Bu) ), minimal spontaneous attachment, but significantly enhanced following P(Bu) stimulation. I had no effect on or without both temperature‐...
A mortality analysis of the Life Esidimeni tragedy was precluded during investigation by Health Ombud lack data integrity. Information on mental healthcare users (MHCUs) transferred out hospitals between October 2015 and June 2016 subsequently collected Gauteng Department Health, permitting statistical analysis. Survival rates were calculated according to gender transfer destination adjusted for patient age. Mortality compared with that general population calendar year 2016. Of 1 442 MHCUs,...
We respond to the recent commentaries on our articles. indicate how statements have been misread, misinterpreted or viewed in narrowest manner possible. Any suggestion of bias 'smoke and mirrors' article is rejected. On contrary, we emphasise that approach was transparent provided a snapshot sector an objective manner.