A5020894899- Health Systems, Economic Evaluations, Quality of Life
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Health and Medical Research Impacts
- Health Policy Implementation Science
- Child and Adolescent Psychosocial and Emotional Development
- Mental Health and Patient Involvement
- Ethics in Clinical Research
- Perfectionism, Procrastination, Anxiety Studies
- Statistical Methods in Clinical Trials
- Biomedical and Engineering Education
- Clinical practice guidelines implementation
- Primary Care and Health Outcomes
- Telemedicine and Telehealth Implementation
- Advanced Causal Inference Techniques
- Patient-Provider Communication in Healthcare
- Mobile Health and mHealth Applications
- Patient Satisfaction in Healthcare
- Meta-analysis and systematic reviews
- Delphi Technique in Research
- Forest Management and Policy
- Infectious Diseases and Mycology
- Health, psychology, and well-being
- Social Media in Health Education
- Salivary Gland Disorders and Functions
- Mental Health Research Topics
Tufts Medical Center
2020-2025
Tufts University
2021-2024
Dartmouth Institute for Health Policy and Clinical Practice
2018
Dartmouth College
2018
University of Manchester
2010
Background Generalized anxiety disorder (GAD) is under-researched despite its high prevalence and large impact on the healthcare system. There a paucity of functional magnetic resonance imaging (fMRI) studies that explore neural correlates emotional processing in GAD. The present study investigated blood oxygen level dependent (BOLD) response to positive negative facial emotions patients with Method A total 15 female GAD 16 controls undertook an implicit face emotion task during fMRI...
Established in 2015, the Multi-Stakeholder Engagement (MuSE) Consortium is an international network of over 120 individuals interested stakeholder engagement research and guidelines. The MuSE group developing guidance for development health healthcare guideline development. this has included multiple meetings with stakeholders, including patients, payers/purchasers services, peer review editors, policymakers, program managers, providers, principal investigators, product makers, public,...
New technologies and disruptions related to Coronavirus disease-2019 have led expansion of decentralized approaches clinical trials. Remote tools methods hold promise for increasing trial efficiency reducing burdens barriers by facilitating participation outside traditional settings taking studies directly participants. The Trial Innovation Network, established in 2016 the National Center Advancing Clinical Translational Science address critical roadblocks research accelerate translational...
Health systems continue to grow in size. Financial integration—the ownership of hospitals or physician practices—often has anticompetitive effects that contribute the higher prices for health care seen US. To determine whether potential harms financial integration are counterbalanced by improvements quality, we surveyed nationally representative samples (n = 739) and practices 2,189), stratified according they were independent owned complex systems, simple medical groups. The surveys...
Objectives/Goals: Despite efforts to support healthcare researchers navigate translational gaps and achieve health impact, impact remains rare. We were interested in determining whether, when, how taking actions optimize the potential of their research. also wanted identify ways optimization. Methods/Study Population: Our sample was drawn from Tufts CTSI’s annual outcomes survey respondents (2017–2022) included tufts principal investigators who had at least one project that reported an...
Abstract Background Health research teams increasingly partner with stakeholders to produce that is relevant, accessible, and widely used. Previous work has covered stakeholder group identification. Objective We aimed develop factors for health consider during identification invitation of individual representatives in a multi-stakeholder partnership, the aim forming equitable informed teams. Design Consensus development. Participants involved 16 from international Multi-Stakeholder...
Multicenter clinical trials play a critical role in the translational processes that enable new treatments to reach all people and improve public health. However, conducting multicenter randomized (mRCT) presents challenges. The Trial Innovation Network (TIN), established 2016 partner with Clinical Translational Science Award (CTSA) Consortium of academic medical institutions implementation mRCTs, consists 3 Centers (TICs) 1 Recruitment Center (RIC). This unique partnership has aimed address...
Few clinics in the United States routinely offer patients audio or video recordings of their clinic visits. While interest this practice has increased, to date, there are no data on prevalence recording visits States.
Despite the intuitive attractiveness of bringing research to participants rather than making them come central study sites, widespread decentralized enrollment has not been common in clinical trials.The need for context COVID-19 pandemic, along with innovations technology, led us use a trial approach our Phase 2 trial. We used real-time acquisition and transmission health-related data using home-based monitoring devices mobile applications assess outcomes. This only avoids spreading but it...
The psychometric tools used for the assessment of generalized anxiety disorder (GAD) either do not conform to current concept condition or have important limitations. We aimed develop and validate a new questionnaire symptom profile severity GAD. An original pool potential scale items was subjected series studies in non-clinical clinical populations, order determine final composition scale. properties scale, Generalized Anxiety Disorder Inventory (GADI), were evaluated using factor analytic...
Contracting delays remain a challenge to the successful initiation of multisite clinical research in US. The Clinical and Translational Science Awards (CTSA) Contracts Processing Study showed average contract negotiation duration > 100 days for industry-sponsored or investigator-initiated contracts. Such create enormous costs sponsors patients waiting use new evidence-based treatments. With support from National Institutes Health's Center Advancing Sciences, Accelerated Trial Agreement...
One challenge for multisite clinical trials is ensuring that the conditions of an informative trial are incorporated into all aspects planning and execution. The multicenter model can provide potential a more environment, but it also place at risk becoming uninformative due to lack rigor, quality control, or effective recruitment, resulting in premature discontinuation and/or non-publication. Key factors support informativeness having right team resources during study implementation adequate...
Ideally, real-world data (RWD) collected to generate evidence (RWE) should lead impact on the care and health of patients. Deriving from in which clinicians patients try various treatments inform therapeutic decisions, N-of-1 trials bring scientific methods practice.
OBJECTIVES/GOALS: Since 2017, we have used the Design Lab methodology to support investigators taking innovative approaches clinical effectiveness trial design. To date held 12 Labs and this year are creating a handbook that will dissemination of approach across Clinical Translational Science Award consortium. METHODS/STUDY POPULATION: The Trial brings together multi-stakeholder group consider impactful designs. An investigative team is selected from competitive pool applicants, after which...
OBJECTIVES/GOALS: Childhood Sjögren’s disease (cSD) is a rare autoimmune disease. Despite the profound impact on children and their families, pediatric-specific clinical trials to inform therapeutic strategies in cSD are lacking. In 2022 we participated Trial Innovation Network (TIN) Design Lab with purpose of designing series N-of-1 for cSD. METHODS/STUDY POPULATION: New medications have potential be safe/effective treatments but must evaluated randomized trials. To overcome limitations...
Abstract Improving the quality and conduct of multi-center clinical trials is essential to generation generalizable knowledge about safety efficacy healthcare treatments. Despite significant effort expense, many are unsuccessful. The National Center for Advancing Translational Science launched Trial Innovation Network address critical roadblocks in by leveraging existing infrastructure developing operational innovations. We provide an overview that led opportunities innovation, our work...
In 2016, the National Center for Advancing Translational Science launched Trial Innovation Network (TIN) to address barriers efficient and informative multicenter trials. The TIN provides a national platform, working in partnership with 60+ Clinical Award (CTSA) hubs across country support design conduct of successful A dedicated Hub Liaison Team (HLT) was established within each CTSA facilitate connection between newly Recruitment Centers. Each HLT serves as an expert intermediary,...
Abstract Background: The Clinical and Translational Science Award Program (CTSA) Trial Innovation Network (TIN) was launched in 2016 to increase the efficiency effectiveness of multisite trials by supporting development national infrastructure. With advent COVID-19 pandemic, it therefore well-positioned support clinical trial collaboration. TIN leveraged two initiatives: (1) create evaluate a mechanism for coordinating Data Safety Monitoring Board (DSMB) activities among multiple ongoing...