Radiotherapy is central in the treatment of cervical cancer. The formation DNA double-strand breaks considered to be critical for radiotherapeutic effect. non-homologous end joining (NHEJ) proteins DNA–PKcs, Ku70 and Ku86 have a major role repairing lesions. objective this study was analyse if expression their downstream signalling molecules p53, p21 Mdm-2 are altered residual tumours after radiotherapy. Retrospective analysis 127 patients with cancer stage IB-IIA treated preoperative...

Because the clinical and histopathologic features of vulvar melanoma had not been characterized completely in a large, homogeneous population, authors retrospectively analyzed all such patients recorded Sweden during 25-year period.The Swedish National Cancer Registry opened its records to for review 219 females with primary reported from 1960 1984. Histopathologic specimens histories 198 who qualified this study were reanalyzed tumors rigorously subtyped.Macroscopically amelanotic observed...

<h3>Aim:</h3> To study time trends in the incidence of conjunctival melanoma Sweden. <h3>Methods:</h3> All patients with from 1960 to 2005 Sweden were identified through Swedish Cancer Registry, cross-checked against hospital files, and validated by histopathological review (97.5%) or detailed records (2.5%). The crude age-standardised incidences estimated separately for each sex annual change over was using a regression model logarithmic numbers. Time largest diameter, thickness location...

Prognostic factors were studied in 770 cases of carcinoma the ovary treated at Radiumhemmet during 1974 to 1979. Centralization treatment a well-defined population with complete follow-up permits nonselective study disease. The analysis was made separately for early and late stages. For cases, histology grading most dominant prognostic factors. advanced successful surgical treatment, either primary or secondary, showed significant relation survival. Successful secondary surgery could be...

The question whether breast cancer is curable remains controversial. Late recurrences and death from the disease are not infrequent. Long term follow-up of a large patient population necessary to study this issue. authors report 14,731 cases reported Cancer Registry Norway with times ranging 5 18 years. A model in which logarithms survival were assumed be normally distributed, lognormal model, fitted data well for individual stages, age groups, periods treatment. cured fraction, i.e.,...

In an epidemiologic study of 219 Swedish females with vulvar melanoma, the authors previously established incidence this disease as 0.19 per 100,000 women, a 3% annual decrease from 1960 to 1984 and 5-year relative survival rate 47%. After reviewing medical histories all patients, documented their precise clinical histopathologic features, which, along treatment, are assessed herein predictors survival.Of consecutive cases melanoma collected National Cancer Registry, 21 were excluded because...

PURPOSE: To evaluate whether S-100B protein in serum is an independent prognostic marker malignant melanoma. MATERIALS AND METHODS: was analyzed 1,007 consecutive patients with histologically verified cutaneous At the time of blood sampling, 876 were clinical stage I, 35 II, and 96 III. The concentrations measured by a luminescence immunoassay (LIA). RESULTS: mean concentration significantly related to stage, lowest level I highest In multivariate analysis, levels showed strongest impact...

S-100 protein was first described in the central nervous system but is also present malignant melanoma cells. Immunohistochemical detection of S-100β widely used histopathological diagnosis melanoma. In study serum levels were measured 643 patients with cutaneous An immunoradiometric assay three monoclonal antibodies against bovine β subunit used. At time blood sampling 553 clinical stage I, 24 II and 66 III. The overall survival rate strongly associated protein. observed/expected death...

Breast cancer is globally the most common malignancy in women. Her2-targeted monoclonal antibodies are established treatment modalities, and vaccines late-stage clinical testing patients with breast known to promote tumour-killing through mechanisms like antibody-dependent cellular cytotoxicity. It therefore increasingly important study immunological consequences of conventional strategies. In this study, functional tests four-colour flow cytometry were used detect natural killer (NK)-cell...

A recurring question in regional and national politics Sweden is how Norrland – a sparsely populated partly declining region the north of country will be able to survive long run. The answer this varies between different political parties. With Swedish parliamentary material (non-government bills) as point departure paper examines used created rhetoric. Four discourses were identified that all tried fixate ways. argues pro-Norrland arguments may counterproductive on discursive level due they...

Accelerating climate change has been associated with, among other things, rising temperatures, sea levels, extensive periods of precipitation, and difficult wind conditions. These are said to affect large segments society, not least outdoor workers, whose working conditions negatively affected. Much media attention paid the situation presents tips on what consider when in such as high temperatures. The aim this paper is explore how Swedish reports workers their relation weather conditions,...

The number of media representations climate activists has increased dramatically in Sweden recently. Some actions have attracted particular attention from Swedish media, such as when stopped traffic and disrupted public events. In this article, I present an analysis both supporters critics terms strategies legitimisation de-legitimisation. study is based on examination 98 texts. results reveal that risk-taking, self-sacrificing, heroisation, normalisation personification are strategies,...

The objective to this retrospective study of 341 cases primary carcinoma vagina (PCV) diagnosed between 1956 and 1996 was find whether epidemiological, clinical, histopathological variables were related the age at diagnosis patients with PCV. univariate statistical analysis showed that younger significantly correlated a history cervical dysplasia, hysterectomy, gynecological infections, tumors located in upper part vagina, whereas older late menarche exophytically growing tumors. In...

To investigate the crude and relative survival rates in patients with uveal melanoma Sweden during period from 1960 to 1998.A population-based national survey revealed 2997 cases of Swedish Cancer Registry. The were calculated by Hakulinen life-table method, using as an estimate for deaths due melanoma. excess mortality confidence intervals first 15 years after diagnosis. Multivariate regression analysis was undertaken evaluate influence gender, age, calendar on 5 underlying causes melanoma,...

Natural killer (NK) activity and NK‐related cell surface markers (CD16, CD56, CD57) of peripheral blood lymphocytes were studied in patients with multiple myeloma MGUS (monoclonal gammopathy undetermined significance). A strong correlation (p &lt; 0.0001) was found between the numbers cells positive for different NK markers. The proportion CD16+cells correlated highly to lytic capability (lytic units/10 6 cells) K562 0.0001). High high a low tumor burden compared controls, whereas values...

Heat shock proteins (HSPs) protect cells against stress‐associated injury and are overexpressed in several malignant tumors. We aimed to investigate their value as prognostic markers prostate cancer. A tissue microarray (TMA) was constructed of 289 cancers from radical prostatectomy (RP) specimens with median follow‐up 48.9 months. Slides were immunostained for HSP27, HSP60 HSP70. Intensity extent immunoreactivity (IR) product (IRp) evaluated by two observers. The IRp HSP27 HSP60, but not...